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Items: 1 to 20 of 105311

1.

Gene expression profiling of Drosophila melanogaster larval brains after chronich alcohol exposure

(Submitter supplied) We sequenced mRNA extracted from brains of (1) D. melanogaster larvae exposed to food containing 5% ethanol (v/v) for 6 conscutive days, and (2) an age-matched untreated control larvae, that grew in regular food. Differential gene expression between the two groups was calculated and reported. Each group consisted of 3 biological replicates of 30 brains each.
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19132
6 Samples
Download data: TXT
Series
Accession:
GSE185625
ID:
200185625
2.

Cut&Tag of ZGA staged embryos

(Submitter supplied) During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development, still, it regulates the activation of only a small subset of genes at ZGA. However, thousands of genes do not require Zelda, suggesting that other mechanisms exist. more...
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25244
8 Samples
Download data: BW
Series
Accession:
GSE173240
ID:
200173240
3.

Interaction of Male Specific Lethal complex and genomic imbalance on global gene expression in Drosophila

(Submitter supplied) Here, in order to investigate the regulation mechanism of the MSL complex in unbalanced genomes and its further functions involved in sexual dimorphism, we over-expressed MSL2 in autosomal aneuploidy (XX, AAA) and sex chromosome aneuploidy (XXX, AA), and analyzed the different transcriptomes.
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13304
16 Samples
Download data: TXT
Series
Accession:
GSE162951
ID:
200162951
4.

Histone variant H2A.Z regulates zygotic genome activation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
4 related Platforms
73 Samples
Download data: BW
Series
Accession:
GSE161594
ID:
200161594
5.

RNA-seq of staged embryos

(Submitter supplied) During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development, still, it regulates the activation of only a small subset of genes at ZGA. However, thousands of genes do not require Zelda, suggesting that other mechanisms exist. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19132 GPL23323
11 Samples
Download data: TSV
Series
Accession:
GSE161593
ID:
200161593
6.

H2A.Z RELACS of ZGA staged embryos

(Submitter supplied) During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development, still, it regulates the activation of only a small subset of genes at ZGA. However, thousands of genes do not require Zelda, suggesting that other mechanisms exist. more...
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL23323
8 Samples
Download data: BW
Series
Accession:
GSE161592
ID:
200161592
7.

MNase-seq of Ctrl and DomKD ZGA embryos

(Submitter supplied) During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development, still, it regulates the activation of only a small subset of genes at ZGA. However, thousands of genes do not require Zelda, suggesting that other mechanisms exist. more...
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25244
4 Samples
Download data: BW
Series
Accession:
GSE161591
ID:
200161591
8.

HiC of Ctrl and DomKD ZGA embryos

(Submitter supplied) During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development, still, it regulates the activation of only a small subset of genes at ZGA. However, thousands of genes do not require Zelda, suggesting that other mechanisms exist. more...
Organism:
Drosophila melanogaster
Type:
Other
Platform:
GPL22106
4 Samples
Download data: BW, H5
Series
Accession:
GSE161590
ID:
200161590
9.

Zygotic transcription of ZGA staged embryos [GRO-seq]

(Submitter supplied) During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development, still, it regulates the activation of only a small subset of genes at ZGA. However, thousands of genes do not require Zelda, suggesting that other mechanisms exist. more...
Organism:
Drosophila melanogaster
Type:
Other
Platform:
GPL22106
6 Samples
Download data: BW, TSV
Series
Accession:
GSE161589
ID:
200161589
10.

ChIP-seq of ZGA staged embryos

(Submitter supplied) During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development, still, it regulates the activation of only a small subset of genes at ZGA. However, thousands of genes do not require Zelda, suggesting that other mechanisms exist. more...
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19132 GPL22106 GPL25244
28 Samples
Download data: BW, TSV
Series
Accession:
GSE161588
ID:
200161588
11.

ATAC-seq of ZGA staged embryos

(Submitter supplied) During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development, still, it regulates the activation of only a small subset of genes at ZGA. However, thousands of genes do not require Zelda, suggesting that other mechanisms exist. more...
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19132 GPL23323
4 Samples
Download data: BW
Series
Accession:
GSE161587
ID:
200161587
12.

Bulk ATAC-seq on whole brain across DGRP lines (homozigous fly lines)

(Submitter supplied) Bulk ATAC-seq performed on whole adult brains across multiple homozigous fly lines (DGRP) in order to find caQTLs. Young adults (1-3 days) were used for all genotypes.
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19132 GPL21306
44 Samples
Download data: MAT
Series
Accession:
GSE181494
ID:
200181494
13.

rDNA transcription initiation complex is required for selective silencing of damaged ribosomal genes in Drosophila

(Submitter supplied) Eukaryotic genomes contain hundreds of nearly identical rRNA genes, many of which are transcriptionally silent. However, the mechanisms of selective regulation of individual rDNA units remain poorly understood. In Drosophila melanogaster, rDNA repeats containing insertions of R1/R2 retrotransposons within the 28S rRNA sequence undergo inactivation, whereas the underlying mechanism of this repression remains unknown. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL30567 GPL21306
8 Samples
Download data: CSV
Series
Accession:
GSE183035
ID:
200183035
14.

Su(H) ChIP-on-chip of Notch-stimulated overgrowing Drosophila melanogaster wing imaginal discs

(Submitter supplied) Aim: Su(H) chromatin occupancy profiling by ChIP on larval wing imaginal discs of Drosophila melanogaster to study the cooperation between Notch activation and loss of epithelial polarity (scrib mutation) during neoplastic growth. Results: The combination of Notch activation and scribble mutation (NS) does not lead to a general redeployment of Su(H) binding as compared to individual conditions (Notch only (N), and scrib mutation only (S))
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL15057
6 Samples
Download data: PAIR, SGR
Series
Accession:
GSE185490
ID:
200185490
15.

Two oppositely-chargedsf3b1 mutations cause defective development, impaired immune response, and aberrant selection of intronic branch sites in Drosophila

(Submitter supplied) Somatic SF3b1 mutations occur in many cancers, and the highly conserved H662 residue is one of the most frequently mutated sites. To address their mechanism on splicing alteration and effects on development, we constructed mutant strains at the corresponding residue H698 in Drosophila using CRISPR-Cas9 system. Two mutations, H698D and H698R, were selected due to their presence in patients and the significantly opposite charges. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23702
15 Samples
Download data: TXT
Series
Accession:
GSE171002
ID:
200171002
16.

RNA-Seq of Notch-stimulated overgrowing Drosophila melanogaster wing imaginal discs

(Submitter supplied) Aim: mRNA profile of larval wing imaginal discs of Drosophila melanogaster to study the cooperation between Notch activation and loss of epithelial polarity (scrib mutation) during neoplastic growth. Results: The combination of Notch activation and scribble mutation (NS) results in mRNA expression changes that, while partly overlapping with Notch only (N), and with scrib mutation only (S), are unique to the combination
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13304
12 Samples
Download data: TXT
Series
Accession:
GSE185339
ID:
200185339
17.

Metabolic gene regulation by Drosophila GATA transcription factor Grain

(Submitter supplied) Nutrient-dependent gene regulation critically contributes to homeostatic control of animal physiology in changing nutrient landscape. In Drosophila, dietary sugars activate transcription factors (TFs), such as Mondo-Mlx, Sugarbabe and Cabut, which control metabolic gene expression to mediate physiological adaptation to high sugar diet. TFs that correspondingly control sugar responsive metabolic genes under conditions of low dietary sugar remain, however, poorly understood. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19132
16 Samples
Download data: XLSX
Series
Accession:
GSE166681
ID:
200166681
18.

Genomics analysis of hexanoic acid exposure in Drosophila species

(Submitter supplied) We analyze the gene expression response to hexanoic acid in Drosophila simulans, Drosophila melanogaster, and Drosophila sechellia
Organism:
Drosophila sechellia; Drosophila simulans; Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24063 GPL27544 GPL21306
18 Samples
Download data: TXT
Series
Accession:
GSE185176
ID:
200185176
19.

Gene expression profiling in ninaE wild type and ninaE G69D/+ Drosophila photoreceptors

(Submitter supplied) Cell type specific gene expression profiling was performed with adult Drosophila photoreceptors. Two genotypes were compared: ninaE wild type control and ninaEG69D/+ mutants that have chronic endoplasmic reticulum stress. To specifically isolate RNAs from these cell types, we drove nuclear envelope-localized EGFP::Msp300KASH expression with the photoreceptor specific Rh1-Gal4 driver. Anti-GFP beads were used to isolate the nuclei from those adult fly photoreceptor cells. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25244
6 Samples
Download data: XLSX
Series
Accession:
GSE185134
ID:
200185134
20.

Repression precedes independent evolutionary gains of a highly specific gene expression pattern

(Submitter supplied) This study addresses how activator and repressor sequences evolve and interact during enhancer evolutiom in the context of a fatty acyl-CoA elongase gene that contributes to pheromone production in Drosophila. The highly specific tissue expression of the gene in the ejaculatory bulb resulted from the initial evolution of a repressor sequence prior to the independent evolution of an activator sequence.
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13304
1 Sample
Download data: FPKM_TRACKING, GTF
Series
Accession:
GSE185053
ID:
200185053
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