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Items: 1 to 20 of 380

1.

RNA SEQ NTHi modA18

(Submitter supplied) Comparison of RNA expression profiles from NTHi strain 84P36H1 strains expressing methyltransferase ModA18 (ON) or not (OFF).
Organism:
Haemophilus influenzae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25730
6 Samples
Download data: TXT
Series
Accession:
GSE129764
ID:
200129764
2.

RNA SEQ NTHi modA15

(Submitter supplied) Comparison of RNA expression profiles from NTHi strain 10P129H1 strains expressing methyltransferase ModA15 (ON) or not (OFF).
Organism:
Haemophilus influenzae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25730
6 Samples
Download data: TXT
Series
Accession:
GSE129761
ID:
200129761
3.

RNA Seq to study gene expression changes mediated by phase-variable DNA methyltransferases in non-typeable Haemophilus influenzae

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Haemophilus influenzae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25730
18 Samples
Download data
Series
Accession:
GSE121835
ID:
200121835
4.

Haemophilus influenzae strain 1209 RNA SEQ NTHi modA9

(Submitter supplied) comparison of RNA expression profiles from NTHi strain 1209 strains expressing methyltransferase ModA9 (ON) or not (OFF)
Organism:
Haemophilus influenzae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25730
6 Samples
Download data: TXT
Series
Accession:
GSE121834
ID:
200121834
5.

Haemophilus influenzae strain 477 RNA SEQ NTHi modA5

(Submitter supplied) comparison of RNA expression profiles from NTHi strain 477 strains expressing methyltransferase ModA5 (ON) or not (OFF)
Organism:
Haemophilus influenzae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25730
6 Samples
Download data: TXT
Series
Accession:
GSE121833
ID:
200121833
6.

Haemophilus influenzae strain C486 RNA SEQ NTHi modA4

(Submitter supplied) comparison of RNA expression profiles from NTHi strain C486 strains expressing methyltransferase ModA4 (ON) or not (OFF)
Organism:
Haemophilus influenzae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25730
6 Samples
Download data: TXT
Series
Accession:
GSE121832
ID:
200121832
7.

Dual RNA-sequencing of nontypeable Haemophilus influenzae and host cell transcriptomes reveals new aspects of host-pathogen interface

(Submitter supplied) Characterization of host-pathogen interactions is critical for the development of next-generation therapies and vaccines. Classical approaches involve the use of transformed cell lines and/or animal models which may not reflect the complexity and response of the human host. We reconstituted the ciliated human bronchial epithelium in vitro using primary bronchial epithelial cells to simultaneously monitor the infection-linked global changes in nontypeable Haemophilus influenzae (NTHi) and infected host epithelia gene expression by dual RNA-seq. more...
Organism:
Homo sapiens; Haemophilus influenzae
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL16791 GPL19560
24 Samples
Download data: TXT
Series
Accession:
GSE63900
ID:
200063900
8.

Phasevarion of non-typeable Haemophilus influenzae R2866

(Submitter supplied) H. influenzae R2866 contains a phase-variable DNA methylase modA10, by virtue of 16 tetrameric repeats present after the start codon. Gain or loss of repeats during replication by slipped-strand mispairing can result in a non-functional reading frame. Microarray analyses of wild-type and insertionally inactivated modA were performed to determine genes affected by phase variable modification.
Organism:
Haemophilus influenzae; Haemophilus influenzae R2866
Type:
Expression profiling by array
Platform:
GPL6594
10 Samples
Download data: XLSX
Series
Accession:
GSE73349
ID:
200073349
9.

Haemophilus influenzae 86-028NP

(Submitter supplied) Transcriptome analysis of NTHi 86-028NPrpsL, NTHi 86-028NPrpsL∆fur, and NTHi 86-028NPrpsL∆fur(pT-fur) strains Nontypeable Haemophilus influenzae (NTHi) is a commensal microorganism of the normal human nasopharyngeal flora, yet also an opportunistic pathogen of the upper and lower respiratory tracts. Changes in gene expression patterns in response to host microenvironments are likely critical for survival. more...
Organism:
Haemophilus influenzae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18879
9 Samples
Download data: XLSX
Series
Accession:
GSE58890
ID:
200058890
10.

Expression analysis of a full SlrV locus 1 knockout in Haemophilus influenzae strain PittII

(Submitter supplied) Investigation of whole genome gene expression differences between a full (four-gene) SlrV locus 1 deletion compared to the WT PittII strain. Removal of the four SlrV genes (aka macrophage survival factors : Δmsf) results in a competetive defect with the WT strain in in vitro biofilms and in the otitis media chinchilla model. It also results in an inability to persist within macrophages long-term in vitro and to escape from the middle-ear space and infect other sites in the chinchilla model.
Organism:
Haemophilus influenzae PittII; Haemophilus influenzae
Type:
Expression profiling by array
Platform:
GPL16197
8 Samples
Download data: PAIR
Series
Accession:
GSE70172
ID:
200070172
11.

A biphasic epigenetic switch controls immunoevasion, virulence and niche adapatation in non-typeable Haemophilus influenzae

(Submitter supplied) Non-typeable Haemophilus influenzae (NTHi) contains an N6-adenine DNA-methyltransferase (ModA), that is subject to phase variable expression (random ON/OFF switching). Five modA alleles, modA2, 4, 5, 9 and 10, account for over two-thirds of clinical otitis media isolates surveyed. Single Molecule Real Time (SMRT) methylome analysis identified the DNA recognition motifs for all five of these modA alleles. more...
Organism:
Haemophilus influenzae
Type:
Expression profiling by array
Platform:
GPL20324
4 Samples
Download data: TXT
Series
Accession:
GSE69831
ID:
200069831
12.

General Approach for Tetramer Based Identification of Autoantigen Reactive B Cells: Characterization of La and snRNP Reactive B Cells in Autoimmune BXD2 Mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Proteus mirabilis; Streptococcus pyogenes; Mycobacterium gordonae; Trypanosoma cruzi; Caprine arthritis encephalitis virus; Human T-cell lymphotrophic virus type 1 (isolate MT-2); Human adenovirus 12; Human endogenous retrovirus K; Human Endogenous Retrovirus IDDMK1,2-22; Torque teno virus; Prochlorococcus marinus str. MIT 9202; Human rotavirus MP409; Paraburkholderia fungorum; Staphylococcus aureus A9635; Klebsiella pneumoniae; Porphyromonas gingivalis; Mycobacterium avium subsp. paratuberculosis; Mycobacterium tuberculosis; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human gammaherpesvirus 4; Human herpesvirus 4 strain B95-8; Human immunodeficiency virus 1; Human herpesvirus 4 type 1; Coxsackievirus B4 (strain E2); Helicobacter pylori; Yersinia enterocolitica; Chlamydia trachomatis; Mycobacterium tuberculosis variant bovis; Human alphaherpesvirus 2; Hepatitis C virus isolate HC-J6; Coxsackievirus B4; Coxsackievirus A20; Porphyromonas gingivalis W83; Mycobacterium avium subsp. paratuberculosis K-10; Escherichia coli; Shigella flexneri; Haemophilus influenzae; Staphylococcus aureus; Lactobacillus delbrueckii subsp. bulgaricus; Mycobacterium avium; Human betaherpesvirus 6; Hepacivirus C; Human T-cell leukemia virus type I; Coxsackievirus A9; Human herpesvirus 4 type 2; Chlamydia pneumoniae; Human poliovirus 3 strain Sabin; Macaca mulatta polyomavirus 1
Type:
Protein profiling by protein array
Platforms:
GPL19700 GPL19692 GPL19701
29 Samples
Download data: XLSX
Series
Accession:
GSE65290
ID:
200065290
13.

Autoimmune peptide antigen reactivity in BXD2 mice with spontaneous systemic autoimmune disease Pepperchip 2.0

(Submitter supplied) The aim of the array was to determine the BXD2 mouse sera IgG and IgM reactivity profile to linear peptide epitopes. Pooled sera from three 6-9 month old BXD2 mice was diluted at 1:200 for IgG specific analysis or 1:1000 for IgM specific analysis and incubated on a PEPperPRINT peptide microarray platform printed with peptide autoantigens
Organism:
Haemophilus influenzae; Lactobacillus delbrueckii subsp. bulgaricus; Mycobacterium avium; Human alphaherpesvirus 1; Human betaherpesvirus 5; Coxsackievirus A9; Coxsackievirus B4 (strain E2); Macaca mulatta polyomavirus 1; Helicobacter pylori; Shigella flexneri; Yersinia enterocolitica; Human alphaherpesvirus 2; Hepatitis C virus isolate HC-J6; Human T-cell leukemia virus type I; Coxsackievirus A20; Torque teno virus; Prochlorococcus marinus str. MIT 9202; Paraburkholderia fungorum; Porphyromonas gingivalis W83; Mycobacterium avium subsp. paratuberculosis K-10; Staphylococcus aureus A9635; Escherichia coli; Klebsiella pneumoniae; Proteus mirabilis; Porphyromonas gingivalis; Staphylococcus aureus; Mycobacterium avium subsp. paratuberculosis; Mycobacterium gordonae; Mus musculus; Human betaherpesvirus 6; Human gammaherpesvirus 4; Hepacivirus C; Human immunodeficiency virus 1; Human herpesvirus 4 type 2; Human herpesvirus 4 type 1; Human endogenous retrovirus K; Chlamydia pneumoniae; Human poliovirus 3 strain Sabin; Chlamydia trachomatis; Streptococcus pyogenes; Mycobacterium tuberculosis variant bovis; Mycobacterium tuberculosis; Trypanosoma cruzi; Homo sapiens; Human herpesvirus 4 strain B95-8; Human T-cell lymphotrophic virus type 1 (isolate MT-2); Coxsackievirus B4; Human adenovirus 12; Human Endogenous Retrovirus IDDMK1,2-22; Human rotavirus MP409
Type:
Protein profiling by protein array
Platform:
GPL19701
2 Samples
Download data: XLSX
Series
Accession:
GSE65278
ID:
200065278
14.

Autoimmune peptide antigen reactivity in normal B6 mice Pepperchip 2.0

(Submitter supplied) The aim of the array was to determine the B6 mouse sera IgG and IgM reactivity profile to linear peptide epitopes. Pooled sera from three 6-9 month old B6 mice was diluted at 1:200 for IgG specific analysis or 1:1000 for IgM specific analysis and incubated on a PEPperPRINT peptide microarray platform printed with peptide autoantigens
Organism:
Escherichia coli; Klebsiella pneumoniae; Shigella flexneri; Staphylococcus aureus; Mycobacterium avium subsp. paratuberculosis; Mus musculus; Human gammaherpesvirus 4; Hepacivirus C; Human immunodeficiency virus 1; Human herpesvirus 4 type 2; Chlamydia pneumoniae; Human poliovirus 3 strain Sabin; Helicobacter pylori; Proteus mirabilis; Yersinia enterocolitica; Porphyromonas gingivalis; Mycobacterium gordonae; Human alphaherpesvirus 2; Hepatitis C virus isolate HC-J6; Human herpesvirus 4 type 1; Coxsackievirus A20; Torque teno virus; Paraburkholderia fungorum; Porphyromonas gingivalis W83; Mycobacterium avium subsp. paratuberculosis K-10; Haemophilus influenzae; Lactobacillus delbrueckii subsp. bulgaricus; Mycobacterium avium; Mycobacterium tuberculosis; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human herpesvirus 4 strain B95-8; Human T-cell leukemia virus type I; Coxsackievirus A9; Prochlorococcus marinus str. MIT 9202; Coxsackievirus B4 (strain E2); Staphylococcus aureus A9635; Macaca mulatta polyomavirus 1; Chlamydia trachomatis; Streptococcus pyogenes; Mycobacterium tuberculosis variant bovis; Trypanosoma cruzi; Human betaherpesvirus 6; Human T-cell lymphotrophic virus type 1 (isolate MT-2); Coxsackievirus B4; Human adenovirus 12; Human endogenous retrovirus K; Human Endogenous Retrovirus IDDMK1,2-22; Human rotavirus MP409
Type:
Protein profiling by protein array
Platform:
GPL19701
2 Samples
Download data: XLSX
Series
Accession:
GSE65277
ID:
200065277
15.

Transcriptome analysis of NTHi 86-028NPrpsL, NTHi 86-028NPrpsL∆fur, NTHi 86-028NPrpsL∆fur∆hrrF, NTHi 86-028NPrpsL∆fur∆hrrF3' strains

(Submitter supplied) Nontypeable Haemophilus influenzae (NTHi) is a commensal microorganism of the normal human nasopharyngeal flora, yet also an opportunistic pathogen of the upper and lower respiratory tracts. Changes in gene expression patterns in response to host microenvironments are likely critical for survival. One such system of gene regulation is the ability to carefully regulate iron uptake. A central regulatory system that controls iron uptake, mediated by the ferric uptake regulator Fur, is present in multiple bacteria, including NTHi. more...
Organism:
Haemophilus influenzae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18879
12 Samples
Download data: XLSX
Series
Accession:
GSE58891
ID:
200058891
16.

Beta- lactam antibiotics stimulate biofilm formation in non-typeable Haemophilus influenzae by up-regulating carbohydrate metabolism

(Submitter supplied) Non-typeable Haemophilus influenzae (NTHi) is a common acute otitis media pathogen, with an incidence that is increased by previous antibiotic treatment. NTHi is also an emerging causative agent of other chronic infections in humans, some linked to morbidity, and all of which impose substantial treatment costs. In this study we explore the possibility that antibiotic exposure may stimulate biofilm formation by NTHi bacteria. more...
Organism:
Haemophilus influenzae
Type:
Expression profiling by array
Platform:
GPL18755
12 Samples
Download data: PAIR
Series
Accession:
GSE58213
ID:
200058213
17.

Expression analysis of a full Lsr locus knockout on the luxS knockout background of Haemophilus influenzae strain CZ4126/02

(Submitter supplied) Investigation of whole genome gene expression differences between a full (nine-gene) Lsr locus deletion and a luxS deletion strain (double knock-out) compared to a luxS isogenic mutant strain (each derived from the CZ4126/02 parent strain). Both strains are unable to produce the autoinducer-2 (AI-2) quorum sensing molecule. In addition, the Lsr mutant is unable to import AI-2 nor mediate any potential LsrR-based transcriptional regulation.
Organism:
Haemophilus influenzae
Type:
Expression profiling by array
Platforms:
GPL18645 GPL16197
64 Samples
Download data: PAIR
Series
Accession:
GSE57288
ID:
200057288
18.

Gene expression of non-typeable Haemophilus influenzae strain R2866 and R2866Δ0112 mutant grown in supplemented brain-heart infusion medium

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Haemophilus influenzae R2866; Haemophilus influenzae
Type:
Expression profiling by array
Platform:
GPL18059
64 Samples
Download data
Series
Accession:
GSE53290
ID:
200053290
19.

Gene expression of non-typeable Haemophilus influenzae strain R2866 and R2866Δ0112 mutant grown in supplemented brain-heart infusion medium for 7 hours

(Submitter supplied) Gene expresison profiles of the R2866 WT and R2866Δ0112 mutant gorwn 7 hours in supplemented brain-heart infusion medium. This experiment was conducted to determine the effects of R2866_0112 gene deletion on overall gene expression profile. The results from this study are further discussed in: Modified lipooligosaccharide structure protects nontypeable Haemophilus influenzae from IgM-mediated complement killing in experimental otitis media. more...
Organism:
Haemophilus influenzae R2866; Haemophilus influenzae
Type:
Expression profiling by array
Platform:
GPL18059
32 Samples
Download data: PAIR
Series
Accession:
GSE53289
ID:
200053289
20.

Gene expression of non-typeable Haemophilus influenzae strain R2866 and R2866Δ0112 mutant grown in supplemented brain-heart infusion medium for 4 hours

(Submitter supplied) Gene expresison profiles of the R2866 WT and R2866Δ0112 mutant gorwn 4 hours in supplemented brain-heart infusion medium. This experiment was conducted to determine the effects of R2866_0112 gene deletion on overall gene expression profile. The results from this study are further discussed in: Modified lipooligosaccharide structure protects nontypeable Haemophilus influenzae from IgM-mediated complement killing in experimental otitis media. more...
Organism:
Haemophilus influenzae R2866; Haemophilus influenzae
Type:
Expression profiling by array
Platform:
GPL18059
32 Samples
Download data: PAIR
Series
Accession:
GSE53287
ID:
200053287
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