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Items: 2

1.

Comparative analysis of gene expression WT and Nrf2-/- mice Type II cells

(Submitter supplied) We hypothesize that gene expression in the Type II cells of Nrf2+/+ and Nrf2-/- mice are divergent thus contributing the cell growth. More specifically, type II cells from Nrf2-/- mice have increased reactive oxygen species that cause the impaired cell growth. In order to test these hypotheses at the gene expression level, we utilized microarray analysis to examine transcriptional differences between Nrf2+/+ and Nrf2-/- cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2875
Platform:
GPL1261
9 Samples
Download data: CEL
Series
Accession:
GSE7810
ID:
200007810
2.
Full record GDS2875

Nrf2-deficient type II lung epithelial cell response to antioxidant supplementation

Analysis of Nrf2 deficient lung epithelial cells treated with the antioxidant glutathione (GSH). GSH rescues cells from prooxidant-induced lung injury associated with Nrf2 deficiency. Results provide insight into the molecular mechanisms by which Nrf2 regulates cellular protection and proliferation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE7810
6 Samples
Download data: CEL
DataSet
Accession:
GDS2875
ID:
2875

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