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Items: 2

1.

Gene expression profiles of striatum and cerebellum from knock-in mouse model of Huntington's disease

(Submitter supplied) Huntington’s disease (HD) involves marked early neurodegeneration in the striatum whereas the cerebellum is relatively spared despite the ubiquitous expression of full-length mutant huntingtin, implying that inherent tissue-specific differences determine susceptibility to the HD CAG mutation. To understand this tissue specificity, we compared early mutant huntingtin-induced gene expression changes in striatum to those in cerebellum in young Hdh CAG knock-in mice, prior to onset of evident pathological alterations. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3935
Platform:
GPL1261
24 Samples
Download data: CEL
Series
Accession:
GSE9038
ID:
200009038
2.
Full record GDS3935

Huntington's disease CAG knock-in effect on striatum and cerebellum

Analysis of striatum and cerebellum of HdhQ111/Q111 CAG knock-ins (expressing full-length huntingtin with 111-glutamines) and wild-type HdhQ7/Q7 mice (expressing full-length huntingtin with 7-glutamines). Results provide insight into tissue-specific differences in susceptibility to HD CAG mutation.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 tissue sets
Platform:
GPL1261
Series:
GSE9038
24 Samples
Download data: CEL

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