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Prkar1a haploinsufficiency leads to an overall increase in tumors caused by other genetic defects or chemical induction

(Submitter supplied) [original title] Prkar1a haploinsufficiency in mice leads to an overall increase in tumors caused by other genetic defects or chemical induction We investigated the Prkar1a+/- mice when bred within the Rb1+/- or Trp53+/- genetic backgrounds, or treated with a 2-step skin carcinogenesis protocol. Prkar1a+/-Trp53+/- mice developed more bone sarcomas than Trp53+/- mice (p<0.05) and Prkar1a+/-Rb1+/- mice grew more and larger pituitary and thyroid tumors than Rb1+/- mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
23 Samples
Download data: TXT
Series
Accession:
GSE19576
ID:
200019576

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