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Items: 2

1.

Gene expression profile of human monocytes stimulated with all-trans retinoic acid (ATRA) or 1,25a-dihydroxyvitamin D3 (1,25D3)

(Submitter supplied) A role for vitamin A in host defense against Mycobacterium tuberculosis has been suggested through epidemiological and in vitro studies; however, the antimicrobial mechanism is unclear. Here, we demonstrate that vitamin A mediates host defense through regulation of cellular cholesterol content. Comparison of monocytes stimulated with all-trans retinoic acid (ATRA) or 1,25-dihydroxyvitamin D3, the biologically active forms of vitamin A and vitamin D respectively, indicates that ATRA and 1,25D3 induce mechanistically distinct antimicrobial activities. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4860
Platform:
GPL570
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE46268
ID:
200046268
2.
Full record GDS4860

All-trans retinoic acid (ATRA) vitamin A and 1,25-dihydroxyvitamin D3 (1,25D3) vitamin D stimulated peripheral blood monocytes

Analysis of monocytes stimulated with biologically active forms of vitamin A and vitamin D. Vitamin A plays a role in host defense against Mycobacterium tuberculosis. Results provide insight into molecular mechanisms underlying the antimicrobial activities for vitamin A and vitamin D in monocytes.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent, 4 individual sets
Platform:
GPL570
Series:
GSE46268
12 Samples
Download data: CEL, CHP

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