GEO DataSets for BioProject (Select 4 documents) - GEO DataSets

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Items: 4

Select item 2000995571.

Expression data from a lung metastatic cell line or metastatic explants in mouse and human

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL23038 GPL23159
40 Samples

Download data: CEL

Series

Accession:: GSE99557

ID:: 200099557

Select item 2000995562.

Expression data from lung metastatic explants

(Submitter supplied) The role of PGC1alpha in breast cancer lung metastasis is largely unknown. We used expression data from lung metastatic explants overexpressing PGC1alpha or control, treated with phenformin to understand global gene expression changes which occur in a PGC1alpha context and under phenformin treatment. We used expression data to understand the pathways and genes that may lead to lung metastasis in a PGC1alpha overexpression setting.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
12 Samples

Download data: CEL, TXT

Series

Accession:: GSE99556

ID:: 200099556

Select item 2000995553.

Expression data from lung metastasis

(Submitter supplied) The role of PGC1alpha in breast cancer lung metastasis is largely unknown. We used expression data from lung metastasis of mice injected with PGC1alpha overexpression or control cells to understand global changes that occur upon overexpression of PGC1alpha that lead to lung metastasis. We used expression data to understand the pathways and genes that may lead to lung metastasis in a PGC1alpha overexpression setting.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
22 Samples

Download data: CEL, TXT

Series

Accession:: GSE99555

ID:: 200099555

Select item 2000995544.

Expression data from a human lung metastatic cell line treated with siPGC1alpha or siControl

(Submitter supplied) To understand global expression changes in a knockdown of PGC1alpha (siPGC1alpha) vs control (siControl) in a lung metastatic cell line (4175) Metabolic adaptations play a key role in fuelling tumour growth. However, less is known regarding the metabolic changes that promote cancer progression to metastatic disease. Herein, we reveal that PGC-1a expression and activity are differentially regulated depending on breast cancer metastatic sites. more...