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Human placental exosomes induce maternal systemic immune tolerance in a monocyte-dependent manner

(Submitter supplied) Maternal immune tolerance toward to the semi-allograft fetus is a prerequisite condition for successful pregnancy. However, the role of maternal monocytes in the induction of systemic immune tolerance is poorly understood. Here we report that placenta facilitates maternal immune tolerance by extruding exosomes. Maternal monocytes were transformed into an immunosuppressive phenotype after taking up exosomes. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30209
8 Samples
Download data: TXT
Series
Accession:
GSE184020
ID:
200184020

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