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Epigenetic signature induced by prolonged culture may impact therapeutic function of Tregs used in adoptive cell therapy

(Submitter supplied) Adoptive transfer of regulatory T cells (Treg) is a promising new therapeutic option to treat detrimental inflammatory conditions. To reach sufficient cell yield for treatment, ex vivo isolated autologous or allogenic Tregs need to be expanded extensively in vitro during manufacturing of the Treg product. However, repetitive cycles of restimulation and prolonged culture have been shown to impact T cell phenotypes, functionality and fitness. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL21145
83 Samples
Download data: IDAT
Series
Accession:
GSE185854
ID:
200185854

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