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Immunodomination leads to selective expansion of the fittest CD8 T cells

(Submitter supplied) During the course of infection, T cells are confronted with a multitude of non self epitopes but only respond to a few epitopes and neglect other potentially immunogenic peptides. Restriction of T cell responses to a small number of selected epitopes (immunodominance) is a central feature of immune responses. Immunodominance is considered to be disadvantageous to the host because it allows pathogens to escape by selectively mutating the relevant epitope(s). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
13 Samples
Download data
Series
Accession:
GSE2924
ID:
200002924

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