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Items: 2

1.

Basonuclin: A novel mammalian maternal effect gene

(Submitter supplied) Basonuclin, which is a zinc-finger protein found in abundance only in the keratinocytes of the stratified epithelium, male germ cells and oocytes, qualifies as a maternal-effect gene because the source of pre-implantation embryonic basonuclin is maternal. Using a transgenic-RNAi approach, we knocked-down basonuclin specifically in mouse oocytes, which led to female sub-fertility. Basonuclin deficiency in oocytes perturbed both RNA polymerase I- and II-mediated transcription and oocyte morphology was affected as evidenced by cytoplasmic and cell surface abnormalities. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1978
Platform:
GPL1261
10 Samples
Download data
Series
Accession:
GSE4029
ID:
200004029
2.
Full record GDS1978

Zinc-finger protein basonuclin knockdown effect on oocytes

Analysis of oocytes following RNAi knockdown of basonuclin (Bnc1), a zinc-finger protein found in abundance in oocytes. The Bnc1 gene qualifies as a maternal-effect gene because the source of pre-implantation embryonic Bnc1 is maternal. Results provide insight into the function of Bnc1.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL1261
Series:
GSE4029
10 Samples
Download data
DataSet
Accession:
GDS1978
ID:
1978

Supplemental Content

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