GEO DataSets for BioProject (Select 96359) - GEO DataSets

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Items: 2

Select item 2000053381.

In vivo function of NR2E3 in establishing photoreceptor identity during mammalian retinal development

(Submitter supplied) Rod and cone photoreceptors in mammalian retina are generated from common pool(s) of neuroepithelial progenitors. NRL, CRX and NR2E3 are key transcriptional regulators that control photoreceptor differentiation. Mutations in NR2E3, a rod-specific orphan nuclear receptor, lead to loss of rods, increased density of S-cones, and supernormal S-cone-mediated vision in humans. To better understand its in vivo function, NR2E3 was expressed ectopically in the Nrl-/- retina, where post-mitotic precursors fated to be rods develop into functional S-cones similar to the human NR2E3 disease. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2455
Platform:: GPL1261
8 Samples

Download data: CEL

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Accession:: GSE5338

ID:: 200005338

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 24552.

Photoreceptor-specific nuclear receptor NR2E3 ectopic expression effect on NRL null retinas

Analysis of 4 week-old neural retinal leucine zipper (NRL) null retinas expressing photoreceptor-specific nuclear receptor (NR2E3) from the cone-rod homeobox (CRX) promoter. NRL, NR2E3, and CRX control photoreceptor differentiation. Results provide insight into the molecular function of NR2E3.