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Items: 3

1.

Expt. C; Daily Rhythm in Expression of >600 Genes in the Rodent Pineal Gland: Dominant Role of Adrenergic/cAMP Signaling

(Submitter supplied) Biological processes are optimized by circadian and circannual biological timing systems. In vertebrates, the pineal gland plays an essential role in these systems by converting time into a hormonal signal, melatonin; in all vertebrates, circulating melatonin is elevated at night, independent of lifestyle. At night, sympathetic input to the pineal gland, originating from the circadian clock in the suprachiasmatic nucleus, releases norepinephrine. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS3701 GDS3702
Platform:
GPL1355
32 Samples
Download data: CEL
Series
Accession:
GSE12343
ID:
200012343
2.
Full record GDS3702

In vitro pineal gland organ culture response to adrenergic/cAMP stimulation (Expt. C)

Analysis of pineal organ cultures treated with norepinephrine (NE) and cAMP. Effects of forskolin also examined. Previous studies of night/day differentially expressed genes suggest control by NE/cAMP signaling. Results of this study expand the scope of the NE/cAMP regulatory cascade.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 agent sets
Platform:
GPL1355
Series:
GSE12343
12 Samples
Download data: CEL
3.
Full record GDS3701

Night and day effects on pineal gland and various other tissues (Expt. C)

Analysis of pineal glands and other tissues (retina, neocortex, cerebellum, hypothalamus, heart, and liver) obtained from Sprague-Dawley rats at mid-day (ZT7) or midnight (ZT19). Results provide insight into genes that characterize the pineal gland, independent of tonic or night/day influences.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 time, 7 tissue sets
Platform:
GPL1355
Series:
GSE12343
20 Samples
Download data: CEL
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