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Downregulation of Myc is essential for terminal erythroid maturation

(Submitter supplied) Terminal differentiation of mammalian erythroid progenitors involves 4-5 cell divisions and induction of many erythroid important genes, followed by chromatin and nuclear condensation and enucleation. The protein levels of c-myc (Myc) are reduced dramatically during late stage erythroid maturation, coinciding with cell cycle arrest in G1-phase and enucleation, suggesting possible roles for c-myc in either or both of these processes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
15 Samples
Download data: TXT
Series
Accession:
GSE18558
ID:
200018558

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