GEO DataSet Links for BioProject (Select 131291) - GEO DataSets

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Items: 2

Select item 2000233941.

Expression data from human NHL cell lines treated with agonistic antibodies

(Submitter supplied) CD20 is a clinically validated target for Non-Hodgkin’s lymphomas and autoimmune diseases. Interactions of CD20 with the B cell receptor (BCR) and components of the BCR signaling cascade have been reported. In this study we show that antibodies against CD20 or activation of the BCR by specific antibodies induce very similar expression patterns of up- or down-regulated genes in NHL cell lines indicating that CD20 may play a role in BCR signaling and vice versa. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4982
Platform:: GPL570
96 Samples

Download data: CEL, XLS

Series

Accession:: GSE23394

ID:: 200023394

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 49822.

Non-Hodgkin’s lymphoma cell lines response to antibodies against CD20 or B-cell receptor

Analysis of NHL lines treated with CD20 or B-cell receptor (BCR) antibodies. CD20 is a B cell-specific, cell surface protein; BCR has a key role in B cell development. Results provide insight into concordance in molecular changes following BCR activation and anti-CD20 Ab treatment in lymphoma cells.