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SIRT1 but not its increased expression is essential for lifespan extension in caloric restricted mice.

(Submitter supplied) The SIRT1 deacetylase is one of the best-studied potential mediators of some of the anti-aging effects of calorie restriction (CR); but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespan than wild type mice on an ad libitum diet. Here we report that median lifespan extension in CR heterozygote SIRT1+/- mice was identical (51%) to that observed in wild type mice but SIRT1+/- mice displayed a higher frequency of some certain pathologies. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
18 Samples
Download data: TXT
Series
Accession:
GSE46895
ID:
200046895

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