GEO DataSet Links for BioProject (Select 229140) - GEO DataSets

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Items: 2

Select item 2000525091.

Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD

(Submitter supplied) Chronic obstructive pulmonary disease (COPD) is characterized by a progressive decline in lung function, caused by exposure to exogenous particles, mainly cigarette smoke (CS). COPD pathogenesis is initiated and perpetuated by an abnormal CS-induced inflammatory response of the lungs, involving both innate and adaptive immunity. Specifically, B cells organized in iBALT structures, as well as macrophages, accumulate in the lungs and contribute to CS-induced emphysema, but the mechanisms thereof remain unclear. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5438
Platform:: GPL6885
12 Samples

Download data: TXT

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Accession:: GSE52509

ID:: 200052509

Select item 54382.

Lung from cigarette smoke-related chronic obstructive pulmonary disease model: time course

Analysis of lung from cigarette smoke (CS)-treated C57BL/6N females at 4 and 6 months of age. Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD). Results provide insight into the molecular mechanisms underlying cigarette smoke-induced COPD.