GEO DataSets

(Submitter supplied) N6-methyladenosine (m6A), installed by the Mettl3/Mettl14 methyltransferase complex, is the most prevalent internal mRNA modification. Whether m6A regulates mammalian brain development is unknown. Here we show that Mettl14 deletion in the embryonic mouse brain diminishes m6A levels, prolongs cell cycle of radial glia cells, and extends cortical neurogenesis into postnatal stages. Mettl3 knockdown also prolongs neural progenitor cell cycle and promotes radial glia cell maintenance. more...

Organism:

Mus musculus; Homo sapiens

Type:

Other

Platforms:

GPL15520 GPL16417 GPL21290

15 Samples

Download data: NARROWPEAK