(Submitter supplied) The intricate regulation of transcription underlies cellular differentiation and development. However, the general relevance of RNA-binding proteins (RBPs) in polymerase (Pol) II transcription is less understood. Here we revealed that WDR43, a novel chromatin-bound RBP, promotes transcription and is essential for self-renewal of embryonic stem cells (ESCs) and early embryonic development. WDR43 binds to promoter-associated non-coding and nascent RNAs, localizes at thousands of gene promoters and enhancers, and interacts with the Pol II transcription machinery.
more...- Organism:
- Mus musculus
- Type:
- Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
- Platforms:
- GPL21273 GPL17021
- 27 Samples
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