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Enoxacin shows a broad-spectrum antiviral activity against diverse viruses by enhancing antiviral RNAi in insects

(Submitter supplied) RNA interference (RNAi) functions as the major host antiviral defense in insects, while less is understood about how to utilize antiviral RNAi in controlling viral infection in insects. Enoxacin belongs to the family of synthetic antibacterial compounds based on a fluoroquinolone skeleton that has been previously found to enhance RNAi in mammalian cells. In this study, we showed that enoxacin efficiently inhibited viral replication of Drosophila C virus (DCV) and Cricket paralysis virus (CrPV) in cultured Drosophila cells. more...
Organism:
Drosophila C virus strain EB; Drosophila melanogaster
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL30984
2 Samples
Download data: TXT
Series
Accession:
GSE189204
ID:
200189204

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