GEO DataSet Links for BioProject (Select 93161) - GEO DataSets

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Items: 2

Select item 2000030671.

Resistance to thyroid hormone (RTH) and PPARa activation

(Submitter supplied) In this study we used the d337T TRb transgenic mouse that has been created to reproduce the human genetic disease known as resistance to thyroid hormone (RTH) as a model to determine if the d337T TRb mutation would have an effect on PPARa activation. A single amino acid deletion (d337T) abrogates thyroid hormone (T3) binding and transforms the thyroid hormone receptor (TRb) into a constitutive repressor. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2371
Platform:: GPL1261
28 Samples

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Accession:: GSE3067

ID:: 200003067

Select item 23712.

Dominant negative thyroid hormone receptor expression and PPARalpha activation effect on the heart

Analysis of hearts of dominant negative thyroid hormone receptor (TR) transgenics after treatment with the peroxisome proliferators activated receptor alpha (PPARalpha) agonist WY14643. Results provide insight into the crosstalk between TR and PPARalpha in the heart.