GEO DataSet Links for BioProject (Select 99083) - GEO DataSets

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Items: 2

Select item 2000068461.

Gene Expression and Biological Processes Influenced By Deletion of Stat3 in pulmonary Alveolar Type II Cells

(Submitter supplied) Deletion of Stat3 induced genes influencing protein metabolism, transport, chemotaxis and apoptosis and decreased the expression of genes mediating lipid synthesis and metabolism. Srebf1 and 2, key regulators of fatty acid and steroid biosynthesis, were decreased in Stat3D/D mice. Stat3 influenced both pro- and anti-apoptotic pathways, regulating and maintaining the balance between a subset of pro- and anti-apoptotic genes that determine cell death or survival. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3106
Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE6846

ID:: 200006846

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 31062.

Stat3 deficiency effect on pulmonary alveolar type II epithelial cells

Analysis of type II alveolar cells lacking signal transducer and activator of transcription 3 (Stat3). STAT3 mediates gene expression in response to numerous growth factors and cytokines, playing an important role in many cellular processes. Results provide insight into the role of Stat3 in lung.