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Links from GEO DataSets

Items: 1 to 20 of 66

1.
Full record GDS4804

Desmin deficiency effect on young and adult skeletal muscles

Analysis of tibialis anterior muscle from 7-9 week old and 12-14 month old 129/Sv animals deficient in desmin. Skeletal muscle fibrosis develops in response to desmin depletion. Results provide insight into the molecular mechanisms underlying muscle fibrosis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE34388
19 Samples
Download data: CEL
2.
Full record GDS5677

Mutant isocitrate dehydrogenase 1 effect on hepatoblasts grown on uncoated plates

Analysis of mutant IDH1 (R132C)-expressing hepatoblasts that were grown on uncoated plates to induce hepatocyte differentiation. IDH genes are frequently mutated in intrahepatic cholangiocarcinoma (IHCC). Results provide insight into the role of IDH1 in hepatocyte differentiation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE57002
4 Samples
Download data: CEL
3.
Full record GDS5676

Mutant isocitrate dehydrogenase 1 and 2 effect on hepatoblasts grown on collagen-coated plates

Analysis of hepatoblasts expressing mutant IDH1 (R132C) and mutant IDH2 (R172K) grown on collagen-coated plates. IDH genes are frequently mutated in intrahepatic cholangiocarcinoma (IHCC). Results provide insight into molecular pathways by which IDH mutations lead to tumor formation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 5 genotype/variation sets
Platform:
GPL8321
Series:
GSE57002
10 Samples
Download data: CEL
4.
Full record GDS5667

Protein tyrosine phosphatase receptor-δ and cyclin-dependent kinase inhibitor 2A deficiency effect on RCAS PDGFB/Nestin tv-A glioma model

Analysis of RCAS PDGFB/Nestin tv-A glioma cells from Ptprd knockout and Cdkn2a/p16Ink4a knockout mice. PTPRD is a tumor suppressor of glioma that is often co-deleted with tumor suppressor p16INK4A. Results provide insight into the cooperative effects of PTPRD and p16INK4A loss in gliomagenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 genotype/variation sets
Platform:
GPL8321
Series:
GSE55061
7 Samples
Download data: CEL
5.
Full record GDS5654

Subcutaneous and visceral adipose tissues

Analysis of adipose tissue from two subcutaneous depots (inguinal and axillary) and two visceral depots (epididymal and mesenteric) from age-matched, C57Bl/6 males. SubQ and VISC represent two broad categories of obesity. Results provide insight into fat depot-specific molecular profiles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 other, 2 tissue sets
Platform:
GPL8321
Series:
GSE53307
12 Samples
Download data: CEL
6.
Full record GDS5637

Platelet-derived growth factor inhibitor effect on lymphocytic cells expressing FIP1L1-PDGFRα or ETV6-PDGFRβ

Analysis of Ba/F3 cells expressing a constitutively active form of PDGFRα or PDGFRβ oncogene (Fip1L1-PDGFRα or TEL-PDGFRβ) and treated with imatinib (Glivec), a potent PDGFR inhibitor. Results provide insight into target genes of the PI3K/PKB/FOXO pathway downstream of growth factor stimulation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 3 genotype/variation, 2 growth protocol sets
Platform:
GPL8321
Series:
GSE44810
6 Samples
Download data: CEL, CHP, DAT, XML
DataSet
Accession:
GDS5637
ID:
5637
7.
Full record GDS5503

Small molecule GW8510 effect on pancreatic beta cell

Analysis of pancreatic beta cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5502, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL8321
Series:
GSE31102
6 Samples
Download data: CEL
8.
Full record GDS5502

Small molecule GW8510 effect on pancreatic alpha cell

Analysis of pancreatic alpha cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5503, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL8321
Series:
GSE31102
6 Samples
Download data: CEL
9.
Full record GDS5500

Stem cell antigen-1 deficient mammary tumor

Analysis of mammary tumors from mutants lacking stem cell antigen-1 (Sca-1), a glycerophosphatidylinositol-anchored protein. Tumorigenesis induced by medroxyprogesterone and 7,12dimethylbenz(a)anthracene treatment. Results provide insight into the role of Sca-1 in mammary gland tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 tissue sets
Platform:
GPL8321
Series:
GSE31954
4 Samples
Download data: CEL
10.
Full record GDS5464

NFATc1 deficiency effect on osteoclast differentiation in vitro

Analysis of osteoclasts lacking the transcription factor NFATc1. Osteoclasts cultured in the presence of M-CSF and RANKL to induce differentiation. Results identify gene targets of NFATc1 in osteoclastogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE37219
4 Samples
Download data: CEL
11.
Full record GDS5344

Streptozotocin-induced type 1 diabetes model: brain hypothalamus

Analysis of hypothalamus from streptozotocin-induced diabetic males (a model of insulin-deficient, type 1 diabetes). The hypothalamus controls the endocrine system, appetite and energy balance. Results provide molecular insight into how diabetes affects hypothalamic function.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 disease state sets
Platform:
GPL8321
Series:
GSE62013
17 Samples
Download data: CEL
12.
Full record GDS5256

Caveolin-1 deficiency effect on dexamethasone treatment: embryonic day E14.5 cerebral cortex

Analysis of E14.5 cerebral cortex, Caveolin-1 (Cav-1) deficient, cultured neurospheres treated with glucocorticoid (GC) dexamethasone (100nM, 4h). Cav-1 involved in GC signaling in neural stem cells. Results provide insight into role of Cav-1 in GC treatment and impact fetal brain development.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE49804
20 Samples
Download data: CEL
13.
Full record GDS5164

GATA-3 deficiency effect on regulatory T cell

Analysis of regulatory T (Treg) cells from mutants deficient for the transcription factor GATA-3. GATA-3 forms a complex with the transcription factor Fox3p, essential in the function of Treg cells. Results provide insight into the role of GATA-3 in the regulation of the Treg transcriptome.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE39864
6 Samples
Download data: CEL
14.
Full record GDS5112

Heart response to Trypanosoma cruzi infection

Analysis of hearts of C57BL/6 animals infected with the intracellular parasite Trypanosoma cruzi. T. cruzi causes Chagas disease which can lead to cardiomyopathy. Results provide insight into the molecular mechanisms underlying the innate immune response in the heart to T. cruzi infections.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 infection sets
Platform:
GPL8321
Series:
GSE41089
6 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS5112
ID:
5112
15.
Full record GDS5065

X-box binding protein 1 overexpression effect on adipocyte cell line

Analysis of F424a adipocytes overexpressing an active spliced form of X-box binding protein 1 (XBP1). XBP is a transcription factor involved in the unfolded protein response. Results provide insight into the function of XBP1 in adipocytes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL8321
Series:
GSE46178
8 Samples
Download data: CEL
16.
Full record GDS4945

FG-3019/gemcitabine combined-treatment effect on KPC model of pancreatic ductal adenocarcinoma

Analysis of PDA tumors isolated from KPC (LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre) mice after combined treatment with FG-3019 (a mAb directed against CTGF) and chemotherapy drug gemcitabine. Results provide insight into the molecular basis of the enhanced anti-PDA activity of FG-3019/gemcitabine.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 protocol sets
Platform:
GPL8321
Series:
GSE46203
24 Samples
Download data: CEL
17.
Full record GDS4928

Acetaminophen effect on thioredoxin reductase 1-null liver

Analysis of liver from hepatocyte-specific, thioredoxin reductase 1 (TrxR1)-null mutants treated with the pro-toxin acetaminophen. The Trx system impacts bioenergetics and drug metabolism. Results provide insight into the role of the Trx system in detoxifying certain xenobiotic challenges.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL8321
Series:
GSE37874
12 Samples
Download data: CEL
18.
Full record GDS4919

Models of rhabdomyosarcoma and undifferentiated pleomorphic sarcoma

Analysis of MyoD-derived sarcomas derived from MDKP (MyoDCE/+; LSL-KrasG12D/+;Trp53Fl/Fl) mice and histological variants (UPS, pleomorphic RMS, and embryonal RMS) from P7KP (Pax7CE/+;LSL-KrasG12D/+;Trp53Fl/Fl) mice. Results provide insight into molecular differences underlying the sarcoma subtypes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 disease state, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE46836
27 Samples
Download data: CEL
19.
Full record GDS4895

SIRT1 deficiency effect on the brain

Analysis of brains deficient for SIRT1. SIRT1 is an NAD-dependent protein deacetylase that play a role in numerous metabolic processes in many tissues, including the brain. Results provide insight into the impact of SIRT1 on brain physiology.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE28790
8 Samples
Download data: CEL
20.
Full record GDS4856

Transcription factor Yin Yang 1 deficiency effect on the skeletal muscle

Analysis of the soleus muscles of transcription factor Yin Yang 1 (YY1) deficient animals. Many nuclear genes encoding mitochondrial proteins contain binding sites for YY1 in their proximal promoters. Results provide insight into the role of YY1 in mitochondrial function.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE39009
7 Samples
Download data: CEL
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