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Links from GEO DataSets

Items: 11

1.
Full record GDS5278

Endometrium response to tamoxifen and low dose estradiol combination therapy

Analysis of endometria of postmenopausal cynomolgus macaques treated with tamoxifen and low dose estradiol. Tamoxifen is a selective estrogen receptor modulator (SERM). Estrogen and SERM co-therapy is an alternative to estrogen and progestin, a treatment associated with increased breast cancer risk.
Organism:
Macaca fascicularis; Macaca mulatta
Type:
Expression profiling by array, count, 4 agent sets
Platform:
GPL3535
Series:
GSE14518
16 Samples
Download data: CEL, CHP
2.
Full record GDS4993

Chronic simian immunodeficiency virus infection: colon, jejunum and lung

Analysis of colon, jejunum and lung from therapy-naïve, SIV-infected males. Gut and lung mucosa are important entry portals for pathogens and provide innate immune defense against infection. Results provide insight into molecular mechanisms underlying mucosal immune response during SIV infection.
Organism:
Macaca mulatta
Type:
Expression profiling by array, count, 2 infection, 3 tissue sets
Platform:
GPL3535
Series:
GSE51615
23 Samples
Download data: CEL
3.
Full record GDS4237

Rhesus macaque type-I interferon agonist effect on peripheral whole blood of SIV-infected Sooty mangabeys: time course

Temporal analysis of whole blood from 8 naturally SIV-infected SMs treated with recombinant RM IFNalpha2-IgFc (rmIFNα2) for 16 weeks. SIV infection of SMs is typically non-pathogenic. Results provide insight into effects of experimentally-augmented IFN-I signaling in chronically SIV-infected SMs.
Organism:
Cercocebus atys; Macaca mulatta
Type:
Expression profiling by array, transformed count, 2 agent, 8 individual, 6 time sets
Platform:
GPL3535
Series:
GSE35460
47 Samples
Download data: CEL
4.
Full record GDS4235

Programmed Death 1 antibody effect on pathogenic Simian Immunodeficiency Virus infection: peripheral blood mononuclear cells

Analysis of PBMCs from SIVmac251-infected (12 wks) rhesus macaques (RMs) treated with an antibody against Programmed Death-1 (PD-1) for 14 days. Results provide insight into the molecular mechanisms by which PD-1 blockade enhances survival of SIV-infected RMs.
Organism:
Macaca mulatta
Type:
Expression profiling by array, transformed count, 3 agent, 2 infection sets
Platform:
GPL3535
Series:
GSE33933
10 Samples
Download data: CEL
5.
Full record GDS4230

Pathogenic Simian Immunodeficiency Virus infection in Rhesus macaques: colorectal tissue

Analysis of colorectal biopsies from SIV-infected Rhesus macaques (RM) and Sooty mangabeys (SM). Unlike AIDS-susceptible RMs, natural hosts such as SMs do not progress to AIDS. Results provide insight into molecular basis of immune activation following pathogenic immunodeficiency virus infections.
Organism:
Cercocebus atys; Macaca mulatta
Type:
Expression profiling by array, transformed count, 3 infection, 2 species, 3 time sets
Platform:
GPL3535
Series:
GSE29980
16 Samples
Download data: CEL
6.
Full record GDS4223

Simian Immunodeficiency Virus infection effect on lymph nodes of Sooty mangabeys and Rhesus macaques

Temporal analysis of lymph nodes of SIVsmm infected Sooty mangabeys (SM) and SIVmac239 infected Rhesus macaques (RM). SIVsmm is non-pathogenic to host SM but origin of pathogens (HIV-2/SIVmac) to humans and RM. Results provide insight into the molecular basis of the differences in host responses.
Organism:
Cercocebus atys; Macaca mulatta
Type:
Expression profiling by array, count, 3 disease state, 3 infection, 2 species, 3 time sets
Platform:
GPL3535
Series:
GSE17626
28 Samples
Download data: CEL
7.
Full record GDS4215

Aging effect on hippocampal regions critical for memory and cognition

Analysis of hippocampal cornu ammonis and dentate gyrus from young and aged female simians. Aging rhesus monkeys develop Metabolic Syndrome (MetS) symptoms and age-related cognitive decline similar to humans. Results provide insight into MetS-associated brain dysfunction in aging.
Organism:
Macaca mulatta
Type:
Expression profiling by array, count, 2 age, 2 tissue sets
Platform:
GPL3535
Series:
GSE11697
23 Samples
Download data: CEL
8.
Full record GDS4214

Simian immunodeficiency virus encephalitis model of HIV-associated dementia: hippocampus

Analysis of hippocampus from simian immunodeficiency virus (SIV) encephalitis and control monkeys. Rhesus SIV encephalitis closely models human HIV-associated dementia (HAD) occurring in patients with advanced HIV. Results provide insight into molecular mechanisms underlying HAD cognitive deficits.
Organism:
Macaca mulatta
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL3535
Series:
GSE13824
36 Samples
Download data: CEL
9.
Full record GDS3863

Controlled ovulation model: dominant follicles

Analysis of ovulatory, luteinizing follicles from a primate model of controlled ovulation at 0, 12, 24, 36 hr after exposure to an ovulatory (exogenous hCG) stimulus during the menstrual cycle. Results provide insight into molecular pathways associated with periovulatory events in primate follicle.
Organism:
Macaca mulatta
Type:
Expression profiling by array, count, 2 agent, 2 development stage, 4 time sets
Platform:
GPL3535
Series:
GSE22776
22 Samples
Download data: CEL
10.
Full record GDS3039

Corpus luteum response to prostaglandin F2alpha

Analysis of corpus lutea (CLs) of animals treated with prostaglandin F2alpha (PGF2alpha). The CL is a transient endocrine gland that produces progesterone, a hormone needed to maintain pregnancy. Results provide insight into the mechanisms underlying the regression of CL mediated by PGF2alpha.
Organism:
Macaca mulatta; Macaca radiata
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL3535
Series:
GSE7971
6 Samples
Download data: CEL, CHP, EXP
11.
Full record GDS2375

Embryonic stem cell lines

Analysis of 5 embryonic stem cell (ESC) lines. Results provide insight into the molecular mechanisms that maintain ESCs in a pluripotent state, and the differences between human and non-human primate ESCs.
Organism:
Macaca mulatta
Type:
Expression profiling by array, count, 6 cell line, 3 development stage sets
Platform:
GPL3535
Series:
GSE4446
9 Samples
Download data: CEL
DataSet
Accession:
GDS2375
ID:
2375
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