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Links from GEO DataSets

Items: 1 to 20 of 33

1.
Full record GDS5415

Model for Wilms tumor of the kidney: time course

Analysis of kidney tumors from Lin28a transgenics at 5 weeks and 4 months of age. Overexpression of heterochronic regulator Lin28 during kidney development promotes Wilms tumor formation. Results provide insight into the role of Lin28 in Wilms tumor formation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 disease state sets
Platform:
GPL6885
Series:
GSE56323
8 Samples
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2.
Full record GDS5879

Pulmonary CDC11c+ cells from young and middle-age animals

Analysis of pulmonary CDC11c+ cells from 6-8 week and 10-13 month old C57BL/6 animals. CDC11c+ cells are key modulators of the immune response in the lung. Results provide insight into molecular mechanisms underlying the decline in immune function associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL6885
Series:
GSE71868
8 Samples
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3.
Full record GDS5803

Radioactive iodine effect on normal thyroid: dose response

Analysis of thyroid from normal BALB/c adults 24 hours after injection in the tail vein with 13, 130, or 260 kBq of radioactive iodine (131I). The absorbed doses to thyroid were 0.85, 8.5, or 17 Gy. Results provide insight into dose-specific molecular responses of thyroid after 131I administration.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 dose sets
Platform:
GPL6885
Series:
GSE54594
4 Samples
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4.
Full record GDS5655

Lymphotoxin-β receptor agonist antibody effect on lipopolysaccharide-stimulated embryonic fibroblasts

Analysis of MEFs treated for 24hrs with ligands lipopolysaccharide (LPS), lymphotoxin-β receptor agonist antibody (LTβR), and LPS+ LTβR. Results provide insight into molecular mechanisms underlying a potentially synergistic effect of LTβR signaling on LPS-TLR4 signaling.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 protocol sets
Platform:
GPL6885
Series:
GSE62301
4 Samples
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5.
Full record GDS5623

Interferon-gamma effect on lipopolysaccharide-activated bone marrow-derived macrophages

Analysis of BMDMs primed with IFNγ and subsequently activated with LPS. Pro-inflammatory macrophages are induced by the Th1 cytokine IFNγ and/or the toll-like receptor ligand LPS. Results provide insight into the molecular effects of IFNγ priming on LPS-induced inflammation in macrophages.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 3 protocol sets
Platform:
GPL6885
Series:
GSE60290
15 Samples
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DataSet
Accession:
GDS5623
ID:
5623
6.
Full record GDS5528

White adipose tissue development

Analysis of developing white adipose tissues (WAT) of C57BL/6 animals at ages 15.5 embyronic days to 12 postnatal days. Results provide insight into the molecular mechanisms underlying the regulation of WAT development.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 8 age sets
Platform:
GPL6885
Series:
GSE29502
8 Samples
Download data
7.
Full record GDS5501

Progranulin deficiency effect on various brain regions: time course

Analysis of brain cortices, cerebella, and hippocampi of progranulin (GRN) deficient mutants at ages 2, 6, and 9 months. GRN mutations cause frontotemporal dementia. Results provide insight into the function of GRN in the central nervous system.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 age, 2 gender, 3 genotype/variation, 3 tissue sets
Platform:
GPL6885
Series:
GSE31840
99 Samples
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8.
Full record GDS5474

TGFβ-activated kinase 1 deficiency effect on liver

Analysis of liver from 4-week old C57BL/6 males with hepatocyte-specific deletion of TGFβ-activated kinase 1 (TAK1). In hepatocytes, TAK1 controls activation of both IKK/NF-κB and JNK pathways. Results provide insight into the role of TAK1 in liver pathophysiology.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6885
Series:
GSE51962
4 Samples
Download data
9.
Full record GDS5469

Left ventricle myocardium from MerCreMer model of transient cardiomyopathy: time course

Temporal analysis of left ventricle myocardium from the MCM model of cardiomyopathy. Transient cardiomyopathy develops in this model after 5 day exposure to tamoxifen, with peak heart failure (HF) at day 10, and resolved HF at day 28. Results provide insight into the molecular basis of evolving HF.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 disease state, 5 protocol, 5 time sets
Platform:
GPL6885
Series:
GSE54681
19 Samples
Download data
10.
Full record GDS5438

Lung from cigarette smoke-related chronic obstructive pulmonary disease model: time course

Analysis of lung from cigarette smoke (CS)-treated C57BL/6N females at 4 and 6 months of age. Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD). Results provide insight into the molecular mechanisms underlying cigarette smoke-induced COPD.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 stress sets
Platform:
GPL6885
Series:
GSE52509
12 Samples
Download data
DataSet
Accession:
GDS5438
ID:
5438
11.
Full record GDS5435

Dietary palatinose effect on liver

Analysis of liver from C57Bl/6J males fed isocaloric diets containing sucrose or palatinose. Sucrose is a high glycemic index (GI) sugar; palatinose is a low GI sugar. Results provide insight into molecular mechanisms underlying the role of sucrose in the development of non-alcoholic fatty liver.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL6885
Series:
GSE54723
14 Samples
Download data
DataSet
Accession:
GDS5435
ID:
5435
12.
Full record GDS5428

CD40 activation effect on DBC1-deficient splenic B cells

Analysis of DBC1-knockout splenic B cells following anti-CD40 activation. The deleted in breast cancer 1 (DBC1) gene was initially identified as part of the 8p22 chromosome region that is deleted in breast cancer. Results provide insight into the role of DBC1 in B cell function.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 4 protocol sets
Platform:
GPL6885
Series:
GSE61029
8 Samples
Download data
13.
Full record GDS5424

Commensal bacteria colonization effect on gnotobiotic model of food allergy: colonic epithelial cells

Analysis of intestinal epithelial cells (IECs) from gnotobiotic animals selectively colonized with Bacteroides uniformis or Clostridia. Results provide insight into the role of microbial interactions with IECs in protecting against sensitization to food allergens.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 protocol sets
Platform:
GPL6885
Series:
GSE60039
8 Samples
Download data
14.
Full record GDS5422

Receptor activator of NF-κB ligand effect on bone marrow-derived macrophage cells: time course

Analysis of bone marrow-derived macrophages (BMMs) collected from 6-8 week old C57BL/6 animals and treated with receptor activator of NF-κB ligand (RANKL) for up to 3 days. Results provide insight into the molecular mechanisms underlying RANKL-mediated induction of osteoclastogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 4 time sets
Platform:
GPL6885
Series:
GSE57468
8 Samples
Download data
15.
Full record GDS5400

DPP4A overexpression effect on fibroblast cell line

Analysis 3T3 fibroblast cells overexpressing the pluripotency factor DPPA4. DPPA4 encodes a DNA binding SAP domain-containing protein. Results provide insight into the role of DPPA4 in oncogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 agent sets
Platform:
GPL6885
Series:
GSE58709
8 Samples
Download data
16.
Full record GDS5376

Homeobox protein Nanog transcription factor overexpression effect on colon and intestine cells

Analysis of colon and intestine cells with ectopic Nanog protein expression. Aggressive tumor progression and poor patient diagnosis have been associated with Nanog expression in different types of tumors. Results provide insight into the role of Nanog in tumor initiation.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol, 2 tissue sets
Platform:
GPL6885
Series:
GSE31413
8 Samples
Download data
DataSet
Accession:
GDS5376
ID:
5376
17.
Full record GDS5370

Ethanol effect on myoblast differentiation in vitro

Analysis of C2C12 cells cultured for up to 3 days in differentiation medium containing ethanol. Chronic alcoholics suffer from weakness and locomotor difficulty resulting from muscle damage. Results provide insight into the signaling pathways affected by ethanol in differentiating myoblasts.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 4 time sets
Platform:
GPL6885
Series:
GSE46492
24 Samples
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18.
Full record GDS5302

Negative elongation factor B subunit deficiency effect on the heart

Analysis of heart left ventricles from mutants lacking the B subunit of negative elongation factor (NELF). NELF is a regulator of RNA polymerase II pausing. Results provide insight into the role of NELF in myocardial function.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6885
Series:
GSE54372
6 Samples
Download data
19.
Full record GDS5300

Restless Legs Syndrome model: embryonic forebrain

Analysis of forebrain from male and female E12.5 embryos heterozygous for the Meis1tm1Mtor allele. These animals express only one functional allele of Meis1, modeling the reduced expression of MEIS1 in Restless Legs Syndrome (RLS) patients. Results provide insight the role of MEIS1 in RLS.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 gender, 3 genotype/variation sets
Platform:
GPL6885
Series:
GSE44592
16 Samples
Download data
20.
Full record GDS5299

Restless Legs Syndrome model: adult whole brain

Analysis of forebrain from male adults heterozygous for the Meis1tm1Mtor allele. These animals express only one functional allele of Meis1, modeling the reduced expression of MEIS1 in Restless Legs Syndrome (RLS) patients. Results provide insight the role of MEIS1 in RLS pathogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6885
Series:
GSE44592
7 Samples
Download data
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