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Links from GEO DataSets

Items: 13

1.
Full record GDS5631

Lipopolysaccharide effect on scavenger receptor MARCO deficient-dendritic cells

Analysis of spleen dendritic cells (DCs) isolated from macrophage receptor with collagenous structure (MARCO)-knockout animals and cultured in media containing TLR agonist LPS. MARCO is part of the innate antimicrobial immune system. Results provide insight into the role of MARCO in activated DCs.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 protocol sets
Platform:
GPL11180
Series:
GSE55068
4 Samples
Download data: CEL
2.
Full record GDS5675

Histone deacetylase HDAC7 re-expression effect on pre-B cell transdifferentiation into macrophages: time course

Analysis of C10 pre-B cells transduced with a vector for HDAC7 expression then treated with β-estradiol to induce transdifferentiation into macrophages for up to 72 hr. Dysregulated HDAC activity is associated with B cell malignancies. Results provide insight into role of HDAC7 in B lymphopoiesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation, 3 time sets
Platform:
GPL11180
Series:
GSE36827
12 Samples
Download data: CEL
3.
Full record GDS5497

Methylphenidate effect on substantia nigra: dose response

Analysis of substantia nigra from animals treated on weekdays with 1 and 10 mg/kg methylphenidate (MPH) for 3 months. MPH is a psychostimulant used for the treatment of ADHD and narcolepsy. Results provide insight into the neurodegenerative consequences of MPH usage.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 3 dose sets
Platform:
GPL11180
Series:
GSE33619
9 Samples
Download data: CEL
4.
Full record GDS5301

Androgen deprivation effect on CD4 T-cells

Analysis of CD4 T cells from castrated animals. Testosterone levels had been observed to be inversely correlated to the strength of the immune response. Results provide insight into the molecular basis of this observation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL11180
Series:
GSE54945
4 Samples
Download data: CEL
5.
Full record GDS5183

Adaptor protein ASC deficiency effect on bone marrow dendritic cells

Analysis of bone marrow dendritic cells of animals lacking ASC, an adaptor protein that contributes to innate immunity via the assembly of inflammasome complexes. Results provide insight into the inflammasome-independent role of ASC in regulating the antigen presenting function of dendritic cells.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL11180
Series:
GSE30769
6 Samples
Download data: CEL, CHP
6.
Full record GDS5054

Diabetes and Obesity Regulated gene gain-of-function effect on skeletal muscle

Analysis of quadriceps from a muscle-specific, Diabetes and Obesity Regulated gene (DOR; also named Tp53inp2) overexpression line (SKM-Tg). DOR gain of function causes a reduction in muscle mass. Results provide insight into the functional role of DOR in skeletal muscle.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL11180
Series:
GSE54917
7 Samples
Download data: CEL
7.
Full record GDS5053

Diabetes and Obesity Regulated gene abalation effect on skeletal muscle

Analysis of quadriceps from a muscle-specific, Diabetes and Obesity Regulated gene (DOR; Tp53inp2) knockout line (SKM-KO). Deletion of DOR results in muscle hypertrophy. Results provide insight into the functional role of DOR in skeletal muscle.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL11180
Series:
GSE54917
6 Samples
Download data: CEL
8.
Full record GDS4821

Platelet-derived growth factor receptor alpha-driven pediatric glioblastoma model with p53 null background

Analysis of high-grade gliomas (HGG) driven by intracranial implantation of p53-null astrocytes expressing any of 6 different mutant forms of platelet derived growth factor receptor alpha (Pdgfrα) found in pediatric HGGs. Results provide insight into the role of PDGFRα mutations in pediatric HGGs.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 disease state, 8 genotype/variation sets
Platform:
GPL11180
Series:
GSE46190
45 Samples
Download data: CEL
9.
Full record GDS4791

Mitochondrial protease Clpp knockout effect on various tissues

Analysis of brain, testis, liver, and heart muscle from C57BL/6 animals deficient in mitochondrial protease Clpp. Loss of Clpp leads to infertility, hearing loss, and growth retardation. Results provide insight into the role of Clpp in growth and survival in a mammalian system.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 4 tissue sets
Platform:
GPL11180
Series:
GSE40207
24 Samples
Download data: CEL
10.
Full record GDS4771

High fat diet effect on liver depleted of promyelocytic leukemia gene

Analysis of livers from promyelocytic leukemia (Pml)-knockouts fed a high fat diet (HFD) for 20 wks. The increased predisposition of Pml-KOs to HFD-induced obesity is associated with aspects of metabolic syndrome. Results provide insight into molecular basis of a metabolic prosurvival role for PML.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL11180
Series:
GSE39220
12 Samples
Download data: CEL, CHP
11.
Full record GDS4572

Tuberous sclerosis complex 1 deficient naïve CD4 and CD8 T cells

Analysis of naïve CD4 and CD8 T cells deficient for Tuberous sclerosis complex 1 (Tsc1). Tsc1 tumor suppressor is an mTOR signaling modulator involved in naive T cell quiescence and immune homeostasis regulation. Results identify a Tsc1-dependent gene signature in naive T cells.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 cell type, 2 genotype/variation sets
Platform:
GPL11180
Series:
GSE29797
10 Samples
Download data: CEL
12.
Full record GDS4434

Tuberous sclerosis complex 1 deficient CD4 T cell response to T cell receptor stimulation

Analysis of Tuberous sclerosis complex 1 (Tsc1) deficient CD4 T cells after T cell receptor stimulation using anti-CD3-CD28. Tsc1 is an mTOR signaling modulator involved in naive T cell quiescence and immune homeostasis regulation. Results provide insight into the role of Tsc1 in T cell quiescence.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL11180
Series:
GSE29797
12 Samples
Download data: CEL
13.
Full record GDS3925

Inflammasome-compromised epidydimal white adipose response to a high fat diet

Analysis of white adipose tissue from inflammasome (IFS) Caspase 1 null (Casp1-/-) and IFS adapter null (ASC-/-) C57/Bl6 males after 16 weeks of high fat diet (HFD) feeding. The mutants were resistant to HFD-induced obesity. Results provide insight into role of IFS in obesity and insulin resistance.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 genotype/variation sets
Platform:
GPL11180
Series:
GSE25205
10 Samples
Download data: CEL
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