Similar studies for GEO DataSets (Select 1234) - GEO DataSets

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Items: 2

Select item 12341.

Fibroblast growth factor receptor 3 K650E mutation for type II thanatophoric dysplasia

Analysis of PC12 cells expressing fibroblast growth factor receptor 3 (FGFR3) K650E mutant responsible for thanatophoric dysplasia (TD) type II. Mutant receptor expressed as a chimera of FGFR3 and platelet derived growth factor receptor. Results provide insight into TD type II pathogenesis.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL85
Series:: GSE2606
8 Samples

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Accession:: GDS1234

ID:: 1234

Select item 2000026062.

Gene expressing profiling of PC12 cells expressing the FGFR3 mutation responsible for thanatophoric dysplasia type II

(Submitter supplied) To investigate signaling pathways activated by FGFR3 mutations through an analysis of altered expression of downstream transcriptional targets, we performed gene expression profiling of stably transfected inducible PC12 cells expressing a chimeric receptor (PFR3) consisting of the extracellular domain of human platelet derived growth factor receptor (PDGFR) and the transmembrane and intracellular domains of human FGFR3 under the control of the zinc inducible metalliothionein promoter. more...