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Links from GEO DataSets

Items: 20

1.
Full record GDS1256

IFN-gamma inflammatory effect on bronchial epithelial cells modulated by dexamethasone: time course

Analysis of bronchial epithelial cells treated with interferon (IFN) gamma, or dexamethasone (dex), or both. IFN-gamma plays a role in lung inflammatory responses and corticosteroids such as dex are used as treatments for inflammation. Cells examined 8 or 24 hours after treatment.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 agent, 2 time sets
Platform:
GPL8300
Series:
GSE1815
36 Samples
Download data
DataSet
Accession:
GDS1256
ID:
1256
2.

The Influence of Interferon Gamma on Gene Expression in Normal Human Bronchial Epithelial Cells

(Submitter supplied) RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone. Keywords = interferon gamma Keywords = dexamethasone Keywords = human bronchial epithelial cells Keywords: dose response
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1256
Platform:
GPL8300
36 Samples
Download data
Series
Accession:
GSE1815
ID:
200001815
3.

Glucocorticoid Induced Changes in Gene Expression in Human Lens Epithelial Cells

(Submitter supplied) Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the short term biological effect of glucocorticoid action in lens epithelial cells is not known. This study seeks to examine glucocorticoid induced changes in global gene expression in LECs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1353
Platform:
GPL96
12 Samples
Download data
Series
Accession:
GSE3040
ID:
200003040
4.
Full record GDS1353

Glucocorticoid effect on lens epithelial cells: time course

Analysis of cultured immortalized lens epithelial cells (LEC) 4 and 16 hours after treatment with 1 uM dexamethasone, a glucocorticoid steroid hormone. Long-term glucocorticoid use can induce cataract formation. Results identify glucocorticoid targets and short-term effects of glucocorticoid on LECs
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL96
Series:
GSE3040
12 Samples
Download data
DataSet
Accession:
GDS1353
ID:
1353
5.

Comparison of gene expression profile of human trabecular meshwork cells induced by triamcinolone with dexamethasone

(Submitter supplied) PURPOSE. Triamcinolone acetonide (TA) and dexamethasone (DEX) are corticosteroids commonly used for ocular inflammation but both can cause ocular hypertension. We investigated the differential gene expression profile of human trabecular meshwork (TM) cells in response to treatment by TA compared to that by DEX. METHODS. Total RNA was extracted from cultured human TM cells treated with TA or DEX and used for microarray gene expression analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4564
9 Samples
Download data
Series
Accession:
GSE6298
ID:
200006298
6.

Transcriptional Response of Human Microglial Cells to Interferon-gamma

(Submitter supplied) Microglial cells are resident macrophages in the central nervous system (CNS) and play a pivotal role in the innate and adaptive immune responses against microbial infections. The immune functions of microglia are regulated by a milieu of cytokines including interferon (IFN)-gamma. We here performed a series of experiments to acertain the transcriptional profile of human fetal microglial cells at 1, 6, and 24 h after IFN-gamma treatment. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1036
Platform:
GPL96
24 Samples
Download data
Series
Accession:
GSE1432
ID:
200001432
7.
Full record GDS1036

Microglial cell response to interferon-gamma: time course

Expression profiling of microglial cells obtained from 4 different samples following treatment with 200 u/ml interferon-gamma (IFN-gamma). Cells examined 1, 6, and 4 hours after treatment. Results provide insight into the regulation of immune functions in microglia by IFN-gamma.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 4 specimen, 3 time sets
Platform:
GPL96
Series:
GSE1432
24 Samples
Download data
DataSet
Accession:
GDS1036
ID:
1036
8.

Epidermal keratinocytes and IFNg, TNFa and IL1 treatment

(Submitter supplied) Cultured epidermal keratinocyte controls used for IFNg, TNFa and IL1 treatment. Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1846
Platform:
GPL8300
9 Samples
Download data: CEL, EXP
Series
Accession:
GSE440
ID:
200000440
9.
Full record GDS1846

Interferon gamma effect on keratinocytes: time course

Analysis of keratinocytes treated with interferon gamma (IFN-gamma) for up to 48 hours. IFN-gamma is a multifunctional, immunomodulatory cytokine with cell type-specific antiviral activities. Results provide insight into molecular processes regulated by IFN-gamma in keratinocytes.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 4 time sets
Platform:
GPL8300
Series:
GSE440
9 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS1846
ID:
1846
10.

Mutual Antagonistic Relationship Between Prostaglandin E2 and Interferon-(gamma): Implications for Rheumatoid Arthritis

(Submitter supplied) PGE2 is a major mediator of inflammation and is present at high concentrations in the synovial fluid of rheumatoid arthritis (RA) patients. PGE2, acting through the EP4 receptor, has both pro- and anti-inflammatory roles in vivo. To shed light on this dual role of PGE2, we investigated its effects in whole blood and in primary human fibroblast-like synoviocytes. Gene expression analysis in human leukocytes, confirmed at the protein level, revealed an EP4-dependent inhibition of the expression of genes involved in the IFN-gamma activation pathway, including IFN-gamma itself. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4372
12 Samples
Download data
Series
Accession:
GSE11575
ID:
200011575
11.

Influence of cyclical mechanical strain on global gene expression in human lamina cribrosa cells in vitro

(Submitter supplied) The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the lamina cribrosa may play a role in this process but the precise cellular responses to mechanical forces in this region are unknown. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
2 Samples
Download data
Series
Accession:
GSE3166
ID:
200003166
12.

Genes regulated by inflammatory cytokines in five primary endothelial cell types

(Submitter supplied) Genes regulated by inflammatory cytokines in five primary endothelial cell types Keywords: ordered
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS498 GDS499 GDS501 GDS502
Platform:
GPL371
15 Samples
Download data
Series
Accession:
GSE569
ID:
200000569
13.
Full record GDS502

Inflammatory cytokine effect on primary colon endothelial cells

Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary colon endothelial cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, log ratio, 3 agent sets
Platform:
GPL371
Series:
GSE569
3 Samples
Download data
DataSet
Accession:
GDS502
ID:
502
14.
Full record GDS501

Inflammatory cytokine effect on primary dermal endothelial cells

Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary dermal endothelial cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, log ratio, 3 agent sets
Platform:
GPL371
Series:
GSE569
3 Samples
Download data
DataSet
Accession:
GDS501
ID:
501
15.
Full record GDS499

Inflammatory cytokine effect on primary aortic endothelial cells

Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary aortic endothelial cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, log ratio, 3 agent sets
Platform:
GPL371
Series:
GSE569
3 Samples
Download data
DataSet
Accession:
GDS499
ID:
499
16.
Full record GDS498

Inflammatory cytokine effect on primary lung endothelial cells

Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary lung endothelial cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, log ratio, 3 agent sets
Platform:
GPL371
Series:
GSE569
3 Samples
Download data
DataSet
Accession:
GDS498
ID:
498
17.

Microarray of Dexamethasone-treated primary chondrocytes identifies downstream targets of glucocorticoid signalling

(Submitter supplied) Background: Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation and decreased bone quality in adults. On a physiological level, GCs have been implicated in the regulation of chondrogenesis and osteoblast differentiation, as well as maintaining homeostasis in cartilage and bone. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2802
Platform:
GPL1261
12 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE7683
ID:
200007683
18.
Full record GDS2802

Dexamethasone effect on fetal chondrocytes in vitro: time course

Analysis of primary cultured fetal chondrocytes treated with pharmacological doses of dexamethasone (DEX) for 6 and 24 hours. DEX is a synthetic glucorticoid (GC) receptor agonist. Results provide insight into the effects of pharmacological GC on chondrocytes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL1261
Series:
GSE7683
12 Samples
Download data: CEL, CHP, EXP
19.

Dexamethasone treatment of gut cells

(Submitter supplied) Reference pool RNA versus RNA from dexamethasone treated gut cells. Keywords: other
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1465
4 Samples
Download data
Series
Accession:
GSE1826
ID:
200001826
20.

Differential Gene Expression in Pulmonary Artery Endothelial Cells Exposed to Sickle Cell Plasma

(Submitter supplied) Clinical variability in sickle cell disease (SCD) suggests a role for extra-erythrocytic factors in the pathogenesis of vasoocclusion. We hypothesized that one potential factor, endothelial dysfunction, results from induction of phenotypic changes by circulating factors in SCD patients. The database reports gene expression in cultured human pulmonary artery endothelial cells (HPAEC) exposed to plasma from: a) sickle acute chest syndrome (ACS) patients (samples ; b) SCD patients at steady-state and c) normal volunteers using microarrays (U133A-B GeneChip Affymetrix). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS1257 GDS1258
Platforms:
GPL97 GPL96
65 Samples
Download data
Series
Accession:
GSE1849
ID:
200001849
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