GEO DataSets

Analysis of gestational day (GD) 17.5 fetal hearts isolated from pregnant C57BL/6Ns treated at GD 14.5 with up to 6.0 ug/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD, a cardiovascular teratogen, inhibits cardiomyocyte proliferation, a process that peaks between GD 14.5 to 17.5.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 4 dose sets

Platform:

GPL81

Series:

GSE2812

20 Samples

Download data: CEL

(Submitter supplied) Pregnant C57Bl6N mice were treated with 0 (corn oil), 1.5, 3.0, or 6.0 ug/kg TCDD on gd14.5. Fetal hearts were collected on gd17.5. Hearts from each litter were pooled onto one chip. 4 replicates of each condition were run on affymetrix MG_U74Av2 chips, using standard affymetrix protocols and controls. Keywords: dose-response, 3 doses plus corn oil control, 4 replicates

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1302

Platform:

GPL81

20 Samples

Download data: CEL

(Submitter supplied) Chronic exposure of Sprague-Dawley (SD) rats to either 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or Aroclor 1254 results in female-selective induction of hepatic tumors. The relative potency of dioxins and PCB mixtures, such as Aroclor 1254, is often estimated using the internationally endorsed toxic equivalency (TEQ) approach. Comparing the genome wide changes in gene expression in both genders following exposure to toxic equivalent doses of these chemicals should identify critical sets of early response genes while further defining the concept of the TEQ of halogenated aromatic hydrocarbons. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

12 Samples

Download data: CEL, XLS

(Submitter supplied) Conventional biochemical and molecular techniques identified previously several genes whose expression is regulated by the aryl hydrocarbon receptor (AHR). We sought to map the complete spectrum of AHR-dependent genes in male adult liver using expression arrays to contrast mRNA profiles in Ahr-null mice (Ahr–/–) with those in mice with wild-type AHR (Ahr+/+). Transcript profiles were determined both in untreated mice and in mice treated 19 h earlier with 1000 µg/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

17 Samples

Download data: CEL, DAT, EXP

(Submitter supplied) This study investigates the effects of the aryl hydrocarbon receptor (AhR) ligands TCDD, PCB126 and PeCDF; the non-AhR ligand PCB153 and the binary mixture PCB126/PCB153 on hepatic gene expression in female sprague dawley rats. Rats were treated with toxicological equivalent doses of TCDD (100ng/kg), PeCDF (200ng/kg), PCB126 (1000ng/kg) and PCB153 (1000ug/kg) 5 days a week for 13 weeks. Keywords: Environmental pollutant toxicity comparison

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

21 Samples

Download data: CEL

(Submitter supplied) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant that produces myriad toxicities in most mammals. In rodents alone, there is a huge divergence in the toxicological response across species, as well as among different strains within a species. But there are also significant differences between males and females animals of a single strain. These differences are inconsistent across model systems: the severity of toxicity is greater in female rats than males, while male mice and guinea pigs are more sensitive than females. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL19143

65 Samples

Download data: CEL, TXT

(Submitter supplied) Rodents exposed to the environmental contaminant, TCDD, suffer from a number of acute and chronic toxicities, including lethality and a wasting syndrome. Hypothesizing that the wasting syndrome may be caused by changes in adipose tissue -- either in its hormonal regulation or in homeostatic effects -- we profiled the transcriptional response of rat white adipose to TCDD. We employed two separate rat strains: the Long-Evans strain is sensitive to TCDD toxicities while the Han/Wistar strain is over four orders of magnitude more resistant. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL9199

28 Samples

Download data: CEL, DAT

(Submitter supplied) In many mammals, halogenated aromatic hydrocarbon (HAH) exposure causes wasting syndrome, defined as lethal weight loss as a result of severe and persistent hypophagia. The most potent HAH in causing wasting is 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD), which exerts its toxic effects through the aryl hydrocarbon receptor (AHR) – a transcription factor. Because TCDD toxicity is thought to predominantly arise from dysregulation of AHR-transcribed genes, we hypothesized that wasting syndrome is due to TCDD-induced dysregulation of genes involved in regulation of food-intake. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL19144

16 Samples

Download data: CEL, TXT

(Submitter supplied) Dioxins are ubiquitous environmental poisons that are developmentally toxic. Exposure of mouse E14 tooth germs to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to reduced tooth size and deformation of cuspal morphology implying the induction of a variety of biological responses on both cellular and molecular levels. To verify such responses at the gene level, mouse embryonic cap staged tooth germs were cultured for 24 h with/without 1 µM TCDD. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2383

Platform:

GPL81

4 Samples

Download data

Analysis of cultured molar teeth from embryonic day 14 fetuses following in vitro treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent toxic dioxin. Results provide insight into the molecular basis of the retardation of dentin mineralization caused by TCDD.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL81

Series:

GSE4873

4 Samples

Download data

(Submitter supplied) Dose-dependent jejunal epithelial gene expression was examined following repeated exposure (every 4 days for 28 days) to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). These data were used to examine the effect of repeated TCDD exposure on jejunal differential gene expression, in order to investigate the role of the jejunum in TCDD-elicited steatohepatitis in C57BL/6.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

48 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL7202 GPL17021

93 Samples

Download data: GPR, TXT

(Submitter supplied) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has a large number of biological effects, including skin, cardiovascular, neurologic disease, diabetes, infertility and cancer. We analysed the in vitro TCDD effects on human CD34+ cells and tested the gene expression modulation by means of microarray analyses before and after TCDD exposure. We identified 253 differentially modulated probe sets, identifying 217 well-characterized genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3889

Platform:

GPL96

8 Samples

Download data: CEL

Analysis of hematopoietic progenitor CD34+ cells from 5 healthy donors (3 paired samples) before and after in vitro 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. Results provide insight into the molecular pathways of TCDD-induced hematopoietic progenitor cell impairment in bone marrow.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 5 individual sets

Platform:

GPL96

Series:

GSE24193

8 Samples

Download data: CEL

(Submitter supplied) Adult zebrafish can completely regenerate their caudal fin following amputation. This complex process is initiated by the formation of an epithelial would cap over the amputation site by 12 hours post amputation (hpa). Once the cap is formed, mesenchymal cells proliferate and migrate from sites distal to the wound plane and accumulate under the epithelial cap forming the blastemal structure within 48 hpa. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS1797

Platform:

GPL1319

18 Samples

Download data: CEL

Analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposed caudal fins at various time points up to 5 days post amputation. TCDD prevents caudal fin regeneration. Results provide insight into the pathways required for fin regeneration and the mechanisms of TCDD toxicity.

Organism:

Danio rerio

Type:

Expression profiling by array, count, 2 agent, 3 time sets

Platform:

GPL1319

Series:

GSE3667

18 Samples

Download data: CEL

(Submitter supplied) Confluent C3H10T1/2 cells stimulated to differentiate using IDMB (1uM BRL49653, 1uM Dexamethasone, 0.5uM IBMX, 10ug/mL Insulin). Expression was examined 24 hours after IDMB treatment. Additionally, the effects of addition of TCDD 48 hours prior to IDMB treatment, and EGF addition concurrent with IDMB treatment were examined. Keywords = Adipogenesis Keywords = TCDD Keywords = EGF Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS951

Platform:

GPL81

18 Samples

Download data: CEL

Analysis of differentiated C3H10T1/2 fibroblasts treated with 10 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and/or 10 nM EGF. Prior to treatment, cells induced to differentiate into adipocytes with IDMB hormone. EGF increases effectiveness of TCDD in suppressing hormone-induced adipogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 8 agent sets

Platform:

GPL81

Series:

GSE1123

18 Samples

Download data: CEL

(Submitter supplied) We have previously shown that in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-elicited NAFLD progression, central carbon, glutaminolysis and serine/folate metabolism are reprogrammed to support NADPH production and ROS defenses. To further investigate underlying dose-dependent responses associated with TCDD-induced fibrosis, female C57BL/6 mice were gavaged with TCDD every 4 days (d) for 28d or 92d. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

27 Samples

Download data: TXT

(Submitter supplied) Alternative splicing is a co-transcriptional mechanism by including or excluding exons in different combinations, thereby expanding the diversity of protein isoforms of a single gene. Abnormalities in this process can result in deleterious effects to human health, and several xenobiotics are known to interfere with splicing regulation through multiple mechanisms. These changes could lead to human diseases such as cancer, neurological disorders, autoimmune diseases, and developmental disorders. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6193

12 Samples

Download data: CEL, TXT