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Links from GEO DataSets

Items: 20

1.
Full record GDS1353

Glucocorticoid effect on lens epithelial cells: time course

Analysis of cultured immortalized lens epithelial cells (LEC) 4 and 16 hours after treatment with 1 uM dexamethasone, a glucocorticoid steroid hormone. Long-term glucocorticoid use can induce cataract formation. Results identify glucocorticoid targets and short-term effects of glucocorticoid on LECs
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL96
Series:
GSE3040
12 Samples
Download data
DataSet
Accession:
GDS1353
ID:
1353
2.

Glucocorticoid Induced Changes in Gene Expression in Human Lens Epithelial Cells

(Submitter supplied) Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the short term biological effect of glucocorticoid action in lens epithelial cells is not known. This study seeks to examine glucocorticoid induced changes in global gene expression in LECs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1353
Platform:
GPL96
12 Samples
Download data
Series
Accession:
GSE3040
ID:
200003040
3.

Comparison of gene expression profile of human trabecular meshwork cells induced by triamcinolone with dexamethasone

(Submitter supplied) PURPOSE. Triamcinolone acetonide (TA) and dexamethasone (DEX) are corticosteroids commonly used for ocular inflammation but both can cause ocular hypertension. We investigated the differential gene expression profile of human trabecular meshwork (TM) cells in response to treatment by TA compared to that by DEX. METHODS. Total RNA was extracted from cultured human TM cells treated with TA or DEX and used for microarray gene expression analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4564
9 Samples
Download data
Series
Accession:
GSE6298
ID:
200006298
4.

The Influence of Interferon Gamma on Gene Expression in Normal Human Bronchial Epithelial Cells

(Submitter supplied) RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone. Keywords = interferon gamma Keywords = dexamethasone Keywords = human bronchial epithelial cells Keywords: dose response
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1256
Platform:
GPL8300
36 Samples
Download data
Series
Accession:
GSE1815
ID:
200001815
5.
Full record GDS1256

IFN-gamma inflammatory effect on bronchial epithelial cells modulated by dexamethasone: time course

Analysis of bronchial epithelial cells treated with interferon (IFN) gamma, or dexamethasone (dex), or both. IFN-gamma plays a role in lung inflammatory responses and corticosteroids such as dex are used as treatments for inflammation. Cells examined 8 or 24 hours after treatment.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 agent, 2 time sets
Platform:
GPL8300
Series:
GSE1815
36 Samples
Download data
DataSet
Accession:
GDS1256
ID:
1256
6.

Influence of cyclical mechanical strain on global gene expression in human lamina cribrosa cells in vitro

(Submitter supplied) The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the lamina cribrosa may play a role in this process but the precise cellular responses to mechanical forces in this region are unknown. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
2 Samples
Download data
Series
Accession:
GSE3166
ID:
200003166
7.

Microarray analysis of changes in gene expression within the amacrine cell layer of chicks following optical defocus

(Submitter supplied) Ocular growth is regulated locally by signals produced in the retina that ultimately act on the growth of the scleral tissue. Consequently, a number of studies have investigated changes in retinal gene expression during manipulation of ocular growth in an attempt to elucidate the biochemical pathways underlying eye growth. However, due to the highly heterogenous nature of the retina, important changes in gene expression can be masked. more...
Organism:
Gallus gallus
Type:
Expression profiling by array
Platform:
GPL3213
9 Samples
Download data: CEL
Series
Accession:
GSE17758
ID:
200017758
8.

Lens Epithelial Cells and Lens Cortical Fiber Cells

(Submitter supplied) Total RNA was isolated from three separate populations of human lens epithelial cells and three matching populations of lens cortical fiber cells. All samples were analyzed on separate microarrays. Keywords: repeat sample
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1327
Platform:
GPL96
6 Samples
Download data
Series
Accession:
GSE2256
ID:
200002256
9.
Full record GDS1327

Lens epithelial and lens cortical fiber cell comparison

Comparison of lens epithelial cells to lens cortical fiber cells. Cells microdissected from lenses of post mortem donors. Results identify genes that may play roles in maintaining the specialized functions of each cell type and provides insight into potential mechanisms of lens cell differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 tissue sets
Platform:
GPL96
Series:
GSE2256
6 Samples
Download data
10.

Expression profiling of skeletal muscle in beef cattle treated with steroidal growth promoters

(Submitter supplied) In the present study, a oligonucleotide microarray platform is used to compare expression profiles of beef cattle muscle in animals treated with either Dexamethazone (Dex) or Dexamethazone plus 17β-estradiol (Estr) administered at sub-therapeutic dosage, against untreated controls. Seventeen male beef cattle 15-18 months old, around 450 kg mean body weight were randomly allocated in three groups: 6 were untreated (group Ctrl), 5 were administered with dexamethazone via feed 0.75mg/head for 43 days (group D); the last 6 animals were administered via feed for 43 days with Dex (0.75mg/head) and intramuscularly (i.m.) for three times with 17β-oestradiol, 20mg/head, (group DE). more...
Organism:
Bos taurus
Type:
Expression profiling by array
Platform:
GPL7053
20 Samples
Download data
Series
Accession:
GSE12179
ID:
200012179
11.

Microarray of Dexamethasone-treated primary chondrocytes identifies downstream targets of glucocorticoid signalling

(Submitter supplied) Background: Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation and decreased bone quality in adults. On a physiological level, GCs have been implicated in the regulation of chondrogenesis and osteoblast differentiation, as well as maintaining homeostasis in cartilage and bone. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2802
Platform:
GPL1261
12 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE7683
ID:
200007683
12.
Full record GDS2802

Dexamethasone effect on fetal chondrocytes in vitro: time course

Analysis of primary cultured fetal chondrocytes treated with pharmacological doses of dexamethasone (DEX) for 6 and 24 hours. DEX is a synthetic glucorticoid (GC) receptor agonist. Results provide insight into the effects of pharmacological GC on chondrocytes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL1261
Series:
GSE7683
12 Samples
Download data: CEL, CHP, EXP
13.

Early responsive genes in human amnion epithelial FL cells induced by N-methyl-N’-nitro-N-nitrosoguanidine

(Submitter supplied) The alkylating agent N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) induces cellular DNA damages and other comprehensive alterations that lead to chromosomal aberrations, mutations, tumor initiations, and cell death. However, the molecular mechanism of MNNG-induced cellular stress remains unclear.We have genome-wide analyzed early transcriptional responses of human FL amnion epithelial cells after exposure to three relatively low doses of MNNG (0.2, 1.0, and 10.0µM),and differential gene expression profiles were obtained 4 h after exposure using oligonucleotide microarrays followed by validation with quantitative real-time RT-PCR. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL96 GPL97
16 Samples
Download data: CEL, EXP
Series
Accession:
GSE8602
ID:
200008602
14.

Interstitial cystitis and antiproliferative factor treatment

(Submitter supplied) Changes in human bladder epithelial cell gene expression associated with interstitial cystitis or antiproliferative factor treatment. Explanted bladder epithelial cells from patients with interstitial cystitis (IC) have been shown to differ from explanted control cells in several ways, including production of an antiproliferative factor (APF), altered production of certain epithelial growth factors, and rate of proliferation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL262
28 Samples
Download data
Series
Accession:
GSE621
ID:
200000621
15.

IC - Experiment 3

(Submitter supplied) Cells from 6 different IC patients were run in parallel with cells from their 6 different matched controls. Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL262
12 Samples
Download data
Series
Accession:
GSE347
ID:
200000347
16.

IC - Experiment 2

(Submitter supplied) Normal bladder epithelial cell explants from 2 different normal controls were treated with APF from 2 different IC patients or mock APF from 2 different matched controls. Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL262
8 Samples
Download data
Series
Accession:
GSE346
ID:
200000346
17.

IC - Experiment 1

(Submitter supplied) Normal bladder epithelial cell explant from a single normal control was treated with APF from a single IC patient or mock APF. Two different membranes were used. Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL262
8 Samples
Download data
Series
Accession:
GSE345
ID:
200000345
18.

Microarray analysis of activated mixed glial (microglia) and monocyte-derived macrophage gene expression.

(Submitter supplied) Since macrophage activation can now be studied at a global level using modern microarray and proteomic analyses, discovery of novel macrophage activation genes is inevitable and important for understanding HIV-associated dementia (HAD). We isolated two different types of primary human macrophages, microglia and monocyte-derived macrophages (MDM) from brain tissue and whole blood respectively. The microarray analysis of differentially regulated macrophage activation genes reported here supports our previous assertions that the mixed glia (MIX) cultured in starvation conditions (DMEM alone) are a non-activated, or “quiescent”, tissue culture model for studying macrophage activation in the brain. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8300
14 Samples
Download data
Series
Accession:
GSE1910
ID:
200001910
19.

Microarray Analysis of Space-flown Murine Thymus Tissue

(Submitter supplied) Microarray Analysis of Space-flown Murine Thymus Tissue Reveals Changes in Gene Expression Regulating Stress and Glucocorticoid Receptors. We used microarrays to detail the gene expression of space-flown thymic tissue and identified distinct classes of up-regulated genes during this process. We report here microarray gene expression analysis in young adult C57BL/6NTac mice at 8 weeks of age after exposure to spaceflight aboard the space shuttle (STS-118) for a period of 13 days. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE18388
ID:
200018388
20.

Dexamethasone treatment of gut cells

(Submitter supplied) Reference pool RNA versus RNA from dexamethasone treated gut cells. Keywords: other
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1465
4 Samples
Download data
Series
Accession:
GSE1826
ID:
200001826
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