GEO DataSets

Analysis of epididymal adipose tissue from M16 polygenic obese animals fed diet containing 1% trans-10 cis-12-conjugated linoleic acid (CLA). Body weight was 12% lower by day 14 on CLA diet. Adipose examined at 5 and 14 days. Results provide insight to mechanisms underlying CLA delipidative effect.

Organism:

Mus musculus

Type:

Expression profiling by array, log10 ratio, 2 time sets

Platform:

GPL891

Series:

GSE1580

4 Samples

Download data: TIFF

(Submitter supplied) Functional genomic analysis of epididymal adipose tissue extracted from polygenic obese mice fed either a control (1% linoleic acid) or treatment (1% trans 10, cis 12 conjugated linoleic acid) diet after five or fourteen days. Keywords = Obesity Keywords = conjugated linoleic acid Keywords = polygenic obese mice Keywords = adiposity Keywords = lipid metabolism Keywords = apoptosis Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1359 GDS1360

Platform:

GPL891

8 Samples

Download data: TIFF

Analysis of epididymal adipose tissue from M16 polygenic obese animals fed diet containing 1% trans-10 cis-12-conjugated linoleic acid (CLA). Body weight was 12% lower by day 14 on CLA diet. Adipose examined at 5 and 14 days. Results provide insight to mechanisms underlying CLA delipidative effect.

Organism:

Mus musculus

Type:

Expression profiling by array, log10 ratio, 2 time sets

Platform:

GPL891

Series:

GSE1580

4 Samples

Download data: TIFF

(Submitter supplied) The white adipose tissue (WAT) rapidly loses mass when mice are fed a diet containing trans-10, cis-12 conjugated linoleic acid (t10c12 CLA). A microarray analysis of WAT due to CLA feeding was performed to better define the processes and genes involved. WAT weight decreased by ca. 80% over 17 days of feeding a 0.5% t10c12 CLA diet. The lipid volume decreased by 90% and the number of adipocytes and total cells were reduced by15% and 47%, respectively. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2197

Platform:

GPL1261

28 Samples

Download data

Analysis of retroperitoneal white adipose tissue (WAT) of C57BL/6J males fed a diet containing 0.5% trans-10 ,cis-12 conjugated linoleic acid (t10c12 CLA) for up to 17 days. Results provide insight into the mechanisms underlying the reduction in fat content of mice WAT in response to t10c12 CLA.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 7 time sets

Platform:

GPL1261

Series:

GSE4671

28 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

66 Samples

Download data: CEL

(Submitter supplied) Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse 3T3-L1 adipocyte tissue culture; however cis-9, trans-11 CLA does not (this series). The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to c9t11 CLA. Their gene expression responses between 8 to 12 hr after treatment showed no gene expression changes indicative of an integrated stress response (ISR). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

10 Samples

Download data: CEL, XLS

(Submitter supplied) Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse white adipose tissue (WAT) and 3T3-L1 adipocyte tissue culture; however in preadipocyte tissue (this series) the UPS/ISR and fat loss is not detected. The early transcriptome changes in 3T3-L1 preadipocyte tissue culture were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

11 Samples

Download data: CEL, XLS

(Submitter supplied) Tunycamcin induces UPR/ISR and Inflammation in mouse 3T3-L1 adipocyte tissue culture. The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to tunicamycin, to be compared with similar experiments with CLA as the treatment. Their gene expression responses between 4 to 12 hr after treatment showed a common set of early gene expression changes indicative of a UPR/Inflammation stress response. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

8 Samples

Download data: CEL, XLS

(Submitter supplied) Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse 3T3-L1 adipocyte tissue culture. The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. Their gene expression responses between 4 to 24 hr after treatment showed a common set of early gene expression changes indicative of an integrated stress response (ISR). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

25 Samples

Download data: CEL, XLS

(Submitter supplied) Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse white adipose tissue (WAT). The early transcriptome changes in WAT were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. Their gene expression responses between 4 to 24 hr after treatment showed a common set of early gene expression changes indicative of an integrated stress response (ISR). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

12 Samples

Download data: CEL, XLS

(Submitter supplied) Pooled RNA samples were prepared for each of the four mouse strainsDU6, DU6i, DUKs, and DBA by epididymal fat tissues of 42 days old 20 male per lines. Pooling was used to reduce individual variability, which is high in outbred populations. For the hybridization of the tissue specific RNAs to the GeneChips, samples were prepared according to the recommendations of the Affymetrix user guide. First strand synthesis was carried out by a T7-(dT)24 primer and SuperScript II Reverse Transcriptase (Gibco BRL, Life Technologies GmbH, Eggenstein, Germany) using 10 mg whole RNA sample. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL76 GPL75

8 Samples

Download data