GEO DataSets

Expression profiling of fetal fibroblasts from tendon, skin, and cornea following mechanical stimulation by fluid flow. Fibroblasts isolated from embryos at 19 days post conception. Results provide insight into differences among fibroblasts from different tissues and response to linear shear stress.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 cell line, 2 stress sets

Platform:

GPL340

Series:

GSE3486

18 Samples

Download data: CEL, EXP

(Submitter supplied) In order to test the hypothesis that fibroblasts from different tissues are phenotypically distinct from one another, we have subjected tendon, skin and corneal fibroblasts of fetal mouse to mechanical stimulation by fluid flow and analyzed the transcriptional responses of the cells using Affymetrix MOE430 chip set containing two arrays MOE430A and MOE430B. Keywords: cell type comparison, stress response

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1500 GDS1501

Platforms:

GPL339 GPL340

36 Samples

Download data: CEL, EXP

Expression profiling of fetal fibroblasts from tendon, skin, and cornea following mechanical stimulation by fluid flow. Fibroblasts isolated from embryos at 19 days post conception. Results provide insight into differences among fibroblasts from different tissues and response to linear shear stress.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 cell line, 2 stress sets

Platform:

GPL339

Series:

GSE3486

18 Samples

Download data: CEL, EXP

(Submitter supplied) The skin is a protective barrier against external insults and any lesion must be rapidly and efficiently repaired. Dermal fibroblasts are the major source of extracellular connective tissue matrix and play an important role in wound healing. Vitamin C is an important water-soluble free radical scavenger and an essential cofactor for collagen synthesis by dermal fibroblasts and, consequently, may contribute to the maintenance of healthy skin. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3635

Platform:

GPL570

9 Samples

Download data: CEL

Analysis of GM5659 skin fibroblasts treated with ascorbic acid or the stable vitamin C derivative, ascorbic acid 2-phosphate. Vitamin C is an important water-soluble free radical scavenger and an essential cofactor for collagen synthesis by dermal fibroblasts.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL570

Series:

GSE11919

9 Samples

Download data: CEL

(Submitter supplied) Rationale: During excessive pressure or overload, cardiac cells are subjected to increased mechanical stress. We investigate how the stress response of cardiac cells to mechanical stress can be compared to genotoxic stresses induced by DNA damaging agents. Methods: Cultures enriched for cardiomyocytes and cultures of fibroblasts were derived from ventricles of neonatal rat hearts. In three independent experiments, both cell cultures were subjected to mechanical stress (cyclic stretch at 60 cycles/min), UV irradiation (10 J/m2), or X-rays (8.5 Gy). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

35 Samples

Download data: CEL, EXP

(Submitter supplied) overexpression of Gtf2iRD1 or TFII-I in MEF cells Keywords: treated vs.untreated

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL986

4 Samples

Download data

(Submitter supplied) The limbus is a unique anatomic structure that is highly innervated and vascularized yet sets the boundary for the avascularized cornea. The corneal epithelial stem cells are believed to reside at the limbus. The intrinsic and external molecular signals that modulate the differentiation and proliferation of the limbal stems cells are still largely unidentified because of a lack of known specific markers. more...

Organism:

Homo sapiens; Chlorocebus sabaeus

Type:

Expression profiling by array

Platform:

GPL570

3 Samples

Download data: CEL

(Submitter supplied) WT,WTR,MU and MUR replicates from Affymetrix GeneChip Mouse Expression Set 430 Arrays A and B Keywords: strain comparison

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1445 GDS1446

Platforms:

GPL340 GPL339

32 Samples

Download data: CEL

Expression profiling of Oct-1 deficient 3T3-immortalized embryonic fibroblasts exposed to gamma radiation. Oct-1 is a POU domain transcription factor. Results provide insight into the role of Oct-1 in the adaptation to cellular stress.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL340

Series:

GSE2084

16 Samples

Download data: CEL

Expression profiling of Oct-1 deficient 3T3-immortalized embryonic fibroblasts exposed to gamma radiation. Oct-1 is a POU domain transcription factor. Results provide insight into the role of Oct-1 in the adaptation to cellular stress.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE2084

16 Samples

Download data: CEL

(Submitter supplied) The cornea continues to mature after birth to develop a fully functional, refractive and protective barrier tissue. Here we investigated the complex biological events underlying this process by profiling global genome-wide gene expression patterns of the immature postnatal day 10 and seven week-old adult mouse cornea. The lens and tendon were included in the study to increase the specificity of genes identified as up regulated in the corneal samples. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

9 Samples

Download data: CEL, CHP