Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 20

1.
Full record GDS1545

Salt sensitive hypertension: kidney (RG-U34A)

Comparison of kidneys from a hypertensive salt-sensitive strain and a congenic salt-resistant strain, with much lower blood pressure (BP). Expression of genes located in the 2.4 cM BP quantitative trait locus (QTL) interval on chromosome 9 examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 strain sets
Platform:
GPL85
Series:
GSE1775
6 Samples
Download data
DataSet
Accession:
GDS1545
ID:
1545
2.

Comparison of renal transcript levels in Dahl Salt-sensitive (S) rat with S.R congenic rat containing a BP QTL

(Submitter supplied) Kidney samples from three Dahl Salt-sensitive S rats were compared with kidney samples from three S.R(9)x3A congenic rats. Keywords = Blood Pressure Keywords = Quantitative trait locus Keywords = QTL Keywords = hypertension Keywords = rat Keywords = congenic Keywords: parallel sample
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS1545 GDS1546 GDS1547
Platforms:
GPL85 GPL86 GPL87
18 Samples
Download data
Series
Accession:
GSE1775
ID:
200001775
3.
Full record GDS1547

Salt sensitive hypertension: kidney (RG-U34C)

Comparison of kidneys from a hypertensive salt-sensitive strain and a congenic salt-resistant strain, with much lower blood pressure (BP). Expression of genes located in the 2.4 cM BP quantitative trait locus (QTL) interval on chromosome 9 examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 strain sets
Platform:
GPL87
Series:
GSE1775
6 Samples
Download data
DataSet
Accession:
GDS1547
ID:
1547
4.
Full record GDS1546

Salt sensitive hypertension: kidney (RG-U34B)

Comparison of kidneys from a hypertensive salt-sensitive strain and a congenic salt-resistant strain, with much lower blood pressure (BP). Expression of genes located in the 2.4 cM BP quantitative trait locus (QTL) interval on chromosome 9 examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 strain sets
Platform:
GPL86
Series:
GSE1775
6 Samples
Download data
DataSet
Accession:
GDS1546
ID:
1546
5.

DEFINING A RAT BLOOD PRESSURE QUANTITATIVE TRAIT LOCUS TO A <81.8KB CONGENIC SEGMENT: COMPREHENSIVE SEQUENCING AND RENAL TRANSCRIPTOME ANALYSIS.

(Submitter supplied) Evidence from multiple linkage and genome-wide association studies suggest that human chromosome 2 (HSA2) contains alleles that influence blood pressure (BP). Homologous to a large segment of HSA2 is rat chromosome 9 (RNO9), to which a BP quantitative trait locus (QTL) was previously mapped. The objective of the current study was to further resolve this BP QTL. Eleven congenic strains with introgressed segments spanning <81.8kb to <1.33Mb were developed by introgressing genomic segments of RNO9 from the Dahl salt-resistant (R) rat onto the genome of the Dahl salt-sensitive (S) rat and tested for BP. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE22515
ID:
200022515
6.

Transcriptional profiling with a Blood Pressure QTL interval-specific oligonucleotide array

(Submitter supplied) Although the evidence for a genetic predisposition to human essential hypertension is compelling, the genetic control of blood pressure (BP) is poorly understood. The Dahl salt-sensitive (S) rat is a model for studying the genetic component of BP. Using this model we previously reported the identification of 16 different genomic regions that contain one or more BP quantitative trait loci (QTLs). The proximal region of rat chromosome 1 contains multiple BP QTLs. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL1350 GPL2796
19 Samples
Download data
Series
Accession:
GSE1622
ID:
200001622
7.

Azoxymethane-induced colorectal tumorigenesis in hypertensive rat models

(Submitter supplied) To compare the tumor susceptibility between the hypertensive Dahl salt-sensitive rats (S) rat and S.LEW(10)x12x2x3x5 (S.LEW) congenic strain, one of the S.LEW congenic strains our laboratory previously constructed on rat chromosome 10 [Hypertension. 2007 Nov;50(5):891-8], Azoxymethane (AOM)-induced colon tumorigenesis in rats was assessed. At six weeks of age, both S and S.LEW congenic rats received intraperitoneal (IP) injection of AOM in sterial saline at a dose of 15mg/kg body weight once a week for two consecutive weeks. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL14746
6 Samples
Download data: TXT
Series
Accession:
GSE75280
ID:
200075280
8.

Identification of Candidate Genes for Alcohol Preference by Expression Profiling of Congenic Strains

(Submitter supplied) A highly significant quantitative trait locus (QTL) that influenced alcohol preference was identified in the iP/iNP rats on chromosome 4. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared to the iNP background strain. This study was undertaken to identify genes in the chromosome 4 QTL interval that might contribute to the differences in alcohol consumption between the alcohol-naïve congenic and background strains. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
60 Samples
Download data: CEL
Series
Accession:
GSE5849
ID:
200005849
9.

Cardiac transcriptome profiles of S.LEW congenic strain compared with the hypertensive Dahl S rat

(Submitter supplied) Despite inheritance of hypertension in families, identifying genetic mechanisms predisposing individuals to hypertension has remained challenging. The effects of single genes contributing to the development of hypertension may not be readily detected in individuals whose genomes also contain other genetic factors that resist hypertension. By using a highly permissive rat genome for inherited hypertension, we demonstrate that increased expression of one such gene, Rififylin (Rffl), is a novel inherited risk factor for hypertension and increased mortality. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3873
Platform:
GPL1355
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE23643
ID:
200023643
10.
Full record GDS3873

Hypertension: heart

Analysis of heart from low-salt diet fed, 53-day old males representing hypertensive, salt-sensitive (S) Dahl strain and congenic strain S.LEW(10)x12x2x3x5. Results provide further insight into molecular basis of hypertension development.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 strain sets
Platform:
GPL1355
Series:
GSE23643
6 Samples
Download data: CEL, CHP
11.

Gene expression in kidney from Lewis and Dahl(S) rat

(Submitter supplied) Male Dahl salt sensitive and Lewis rats (n=3 each) were fed an 8% NaCl diet starting at 5 weeks of age for 8 weeks. Total RNA was isolated with TRIzol reagent from DS and LEW kidneys and was subjected to microarray analysis. Keywords: animals with different genetic background comparison
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS2710
Platform:
GPL1355
6 Samples
Download data
Series
Accession:
GSE4800
ID:
200004800
12.
Full record GDS2710

Salt-sensitive hypertension model: kidney

Analysis of kidneys from Dahl salt-sensitive males fed a high salt diet. The Dahl salt sensitive animal is used as a model of hypertension. Results combined with quantitative trait loci analyses to identify candidate genes that influence blood pressure levels.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 strain sets
Platform:
GPL1355
Series:
GSE4800
6 Samples
Download data
DataSet
Accession:
GDS2710
ID:
2710
13.

Mapping of a QTL for airway hyperresponsiveness on mouse chromosome 12

(Submitter supplied) The BcA86 strain is a unique recombinant congenic strain created from parental strains A/J and C57BL/6J. Naive mice from the BcA86 strain have a lung responsiveness phenotype resembling mice from airway hyperresponsive strain A/J. However, majority of the BcA86 genome is from the hyporesponsive strain C57BL/6J. Our goal was to identify the genomic regions that are associated with this BcA86 phenotype. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
9 Samples
Download data: CEL
Series
Accession:
GSE52356
ID:
200052356
14.

SHR kidney

(Submitter supplied) Affymetrix RG U34A analysis of renal gene expression in Wistar-derived rat strains Keywords: repeat sample
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL85
55 Samples
Download data
Series
Accession:
GSE2104
ID:
200002104
15.

Evaluation of expression quantitative trait loci within two interacting blood pressure quantitative trait loci

(Submitter supplied) Genetic dissection of the S rat genome has provided strong evidence for the presence of two interacting blood pressure (BP) quantitative trait loci (QTLs), termed QTL1 and QTL2, on rat chromosome 5. However, the identities of the underlying interacting genetic factors remain unknown. Further experiments targeted to identify the interacting genetic factors by the substitution mapping approach alone are difficult because of the interdependency of natural recombinations to occur at the two QTLs. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL5127 GPL5126
30 Samples
Download data
Series
Accession:
GSE7628
ID:
200007628
16.

Age-related retinal degeneration study in mice

(Submitter supplied) The first goal of the study was to find the genes that explain the difference in progression of age-related retinal degeneration (ageRD) between the inbred strains C57BL/6J-c2J (B6a) and BALB/cByJ (C). The specific goal was to find the candidate genes that explain the chromosome 6 and chromosome 10 quantitative trait loci (QTL) found in a previous study. Genes differentially expressed in retina between both strains and that map to the QTL are candidate genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL9214
16 Samples
Download data
Series
Accession:
GSE18151
ID:
200018151
17.

Mouse Diversity Array SNP Genotyping of B10.BALBChr16 and BALB.B10Chr16 Reciprocal Consomic Strain Mice

(Submitter supplied) To identify novel mechanisms regulating allogeneic hematopoietic cell engraftment, we previously used a forward genetic approach and described identification, in mice, of the Bmgr5 bone marrow (BM) engraftment quantitative trait locus (QTL). This QTL confers dominant and large allele effects for engraftment susceptibility. It was localized to chromosome 16 by classical quantitative genetic techniques in a segregating backcross bred from susceptible BALB.K and resistant B10.BR mice. more...
Organism:
Mus musculus
Type:
Genome variation profiling by SNP array
Platform:
GPL13147
2 Samples
Download data: CEL
Series
Accession:
GSE43377
ID:
200043377
18.

Gene expression profile in spleens of mice 24 hours after total body irradiation.

(Submitter supplied) A major challenge in bone allogeneic marrow (BM) transplantation is overcoming engraftment resistance to avoid the clinical problem of graft rejection. Identifying genes and pathways that regulate BM engraftment may reveal molecular targets for overcoming these engraftment barriers. Previously, we developed a mouse model of BM transplantation that utilizes recipient conditioning with non-myeloablative total body irradiation followed by transplantation of allogeneic BM cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
24 Samples
Download data: TXT
Series
Accession:
GSE43310
ID:
200043310
19.

Candidate genes for alcohol preference in alcohol-preferring and non-preferring reciprocal congenic rats

(Submitter supplied) The goal of this study was to identify candidate genes that may influence alcohol consumption by comparing gene expression in 5 brain regions of alcohol-naïve iP and P.NP rats. Background: Selectively bred P (alcohol preferring) and NP (alcohol non-preferring) rats differ greatly in alcohol preference, in part due to a highly significant QTL on chromosome 4. Reciprocal congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP background (NP.P) and the iNP chromosome 4 QTL was transferred to the iP background (P.NP) exhibited alcohol consumption scores that correlated with the introgressed interval. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
80 Samples
Download data: CEL
Series
Accession:
GSE15415
ID:
200015415
20.

Positional identification of Adamts16 variants linked to inherited hypertension

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
13 Samples
Download data: CEL, CHP
Series
Accession:
GSE12869
ID:
200012869
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=3|blobid=MCID_6143347b501b6049166a6140|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center