GEO DataSets

Analysis of embryonic day 13.5 trigeminal ganglia of Brn3a knockout mutants. Brn3a encodes a POU-domain transcription factor. Results provide insight into the molecular mechanisms underlying the essential role of the Brn3a protein in normal axon growth and neuronal survival.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 genotype/variation sets

Platform:

GPL82

Series:

GSE3895

5 Samples

Download data

(Submitter supplied) Mice lacking the POU-domain transcription factor Brn3a exhibit marked defects in sensory axon growth and abnormal sensory apoptosis. We have determined the regulatory targets of Brn3a in the developing trigeminal ganglion using microarray analysis of Brn3a mutant mice. These results show that Brn3 mediates the coordinated expression of neurotransmitter systems, ion channels, structural components of axons and inter- and intracellular signaling systems. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1651 GDS1652

Platforms:

GPL82 GPL81

11 Samples

Download data

Analysis of embryonic day 13.5 trigeminal ganglia of Brn3a knockout mutants. Brn3a encodes a POU-domain transcription factor. Results provide insight into the molecular mechanisms underlying the essential role of the Brn3a protein in normal axon growth and neuronal survival.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 genotype/variation sets

Platform:

GPL81

Series:

GSE3895

6 Samples

Download data

(Submitter supplied) General somatic sensation is conveyed to the central nervous system at cranial levels by the trigeminal ganglion (TG), and at spinal levels by the dorsal root ganglia (DRG). Although these ganglia have similar functions, they have distinct embryological origins, in that both contain neurons originating from the neural crest, while only the TG includes cells derived from the placodal ectoderm. Here we use microarray analysis of E13.5 embryos to demonstrate that the developing DRG and TG have very similar overall patterns of gene expression. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL81 GPL339 GPL82

17 Samples

Download data

(Submitter supplied) The nuclear LIM-only protein LMO4 is upregulated in breast cancer, especially estrogen receptor negative tumors, and its overexpression in mice leads to hyperplasia and tumor formation. Here, we show that deletion of LMO4 in the mammary glands of mice leads to impaired lobuloalveolar development due to decreased epithelial cell proliferation. With the goal of discovering potential LMO4-target genes, we also developed a conditional expression system in MCF-7 cells for both LMO4 and a dominant negative (DN) form of its co-regulator, Co-factor of LIM domains (Clim/Ldb/Nli). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS2787 GDS2788 GDS2789

Platforms:

GPL96 GPL570 GPL97

18 Samples

Download data: CEL

Analysis of breast cancer MCF-7 cells after the induction of expression of a dominant negative form of the cofactor of LIM domains (CLIM), a co-regulator of the nuclear LIM only protein 4 (LMO4). LMO4 is upregulated in breast cancer. Results provide insight into the role of LMO4 in tumor formation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL570

Series:

GSE7382

6 Samples

Download data: CEL

Analysis of breast cancer MCF-7 cells following the induction of expression of nuclear LIM-only protein 4 (LMO4). LMO4 is upregulated in breast cancer. Results provide insight into the role of LMO4 in promoting tumor formation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL97

Series:

GSE7382

6 Samples

Download data: CEL

Analysis of breast cancer MCF-7 cells following the induction of expression of nuclear LIM-only protein 4 (LMO4). LMO4 is upregulated in breast cancer. Results provide insight into the role of LMO4 in promoting tumor formation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL96

Series:

GSE7382

6 Samples

Download data: CEL

(Submitter supplied) Overall study: Identification of PDGF-dependent patterns of gene expression in U87 glioblastoma cells. RNA was obtained from triplicate dishes of 5 different groups of U87 cells, each (total 15) analyzed with one U95 microarray chip. Three different comparisons were made: 1) Clone 3.1 (34580-34582) vs. clone 3.3 (34583-34585) vs. parent U87 (34592-34594). Purpose: demonstrate that the gene expression profiles between these 3 cell lines are not different, so they could be pooled as a single untreated group. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1730

Platform:

GPL8300

15 Samples

Download data: CEL, EXP

Analysis of U87 glioblastoma (GBM) cell clones overexpressing a dominant-negative form of platelet-derived growth factor (PDGF) A subunit to inactive the PDGF autocrine signaling loop. The autocrine PDGF loop is a hallmark of GBM. Results identify genes regulated by oncogenic PDGF signaling.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 genotype/variation sets

Platform:

GPL8300

Series:

GSE1923

15 Samples

Download data: CEL, EXP

(Submitter supplied) To identify novel Nurr1 target genes we have used microarrays strategies in rat midbrain primary cultures, enriched in dopaminergic neurons, by the action of basic fibroblast growth factor (bFGF, 20ng/ml) and Sonic hedgedog (SHH), following upregulation of Nurr1 expression by depolarization.To this aim we have treated the cultures after 9 days in vitro for 2h with high KCl and collected 30 min or 2 h after the end of depolarization (2h + 30 min or 2h + 2h). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2774

Platform:

GPL341

12 Samples

Download data

Analysis of cultured midbrain neurons enriched for dopaminergic neurons following Nurr1 overexpression induced by depolarization. Nurr1 is a transcription factor essential for the generation of midbrain dopaminergic neurons. Results provide insight into the molecular pathways regulated by Nurr1.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 4 protocol sets

Platform:

GPL341

Series:

GSE4551

12 Samples

Download data