GEO DataSets

Analysis of aortic rings treated with angiopoietin-1 (Ang-1) or vascular endothelial growth factor (VEGF). Aortic rings can generate neovessels ex vivo after angiogenic factor stimulation. Results identify transcriptional events associated with angiogenesis in VEGF and Ang-1 stimulated aortic rings.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL342

Series:

GSE3355

8 Samples

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(Submitter supplied) Specific Aims To identify novel transcriptional events associated with angiogenesis in VEGF and Ang-1 stimulated rat aortic rings. Our studies take advantage of the capacity of rat aortic rings to generate new vessels in collagen gels. Rat aortic rings embedded in collagen gel immediately after excision from the animal produce a self-limited angiogenic response under serum-free conditions and in the absence of exogenous stimuli. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS1922 GDS1923

Platforms:

GPL341 GPL342

18 Samples

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Analysis of aortic rings treated with angiopoietin-1 (Ang-1) or vascular endothelial growth factor (VEGF). Aortic rings can generate neovessels ex vivo after angiogenic factor stimulation. Results identify transcriptional events associated with angiogenesis in VEGF and Ang-1 stimulated aortic rings.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL341

Series:

GSE3355

9 Samples

Download data

(Submitter supplied) Angiogenesis in cultures of rat aorta begins with neovessels sprouting from the aortic explant within the first three days of culture. We used microarrys to examine the effects of TNF-alpha on gene expression in both fibrin and collagen gels during the first 48 hours or culture.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

12 Samples

Download data: CEL

(Submitter supplied) Angiogenesis in collagen gel cultures of rat aorta begins with neovessels sprouting from the aortic explant within the first three days of culture. We used microarrays to detail the pattern of gene expression underlying initial 24 hours of growth, prior to the sprouting of visible neovessles, and identified distinct classes of up-regulated genes during this process.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

6 Samples

Download data: CEL

(Submitter supplied) Genes regulated by inflammatory cytokines in five primary endothelial cell types Keywords: ordered

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS498 GDS499 GDS501 GDS502

Platform:

GPL371

15 Samples

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Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary colon endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

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Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary dermal endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

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Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary aortic endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

Download data

Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary lung endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

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(Submitter supplied) Endocardial (EE) and Aortic (AE) endothelial cells were isolated from the same two rats, pooled (EE and AE kept separately) and cultured for 2 passages. Culture conditions and confluence of EE and AE cell cultures were kept as identical as possible. RNA was isolated and the expression profile of both endothelial cell types was compared using the Affymetrix rat genome U34A array. Keywords: parallel sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS695

Platform:

GPL85

2 Samples

Download data: CEL, EXP, RPT

Gene expression profiles of endocardial (EE) and aortic (AE) endothelial cells. EE and AE genetic diversity in culture reflects in vivo physiological diversity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 cell type sets

Platform:

GPL85

Series:

GSE1478

2 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) Angiogenesis, the formation of new capillaries by sprouting from preexisting vessels, is mainly induced by VEGF-A. To identify genes which are induced by VEGF-A in endothelial cells, HUVEC were starved and induced by VEGF-A165 for 30, 60 and 150min. RNA of induced and uninduced cells was isolated and subjected to microarray analysis using Affymetrix microarray.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3567

Platform:

GPL570

4 Samples

Download data: CEL, CHP

(Submitter supplied) Angiogenesis is defined as the formation of new capillaries by sprouting from preexisting vessels. It is mainly triggered by vascular endothelial growth factor (VEGF) and occurs in the adult primarily in wound healing processes or in pathologic tumor vessel growth. To identify genes specifically triggered by VEGF and involved in the process of angiogenesis, we utilized Affymetrix microarrays hybridized with cRNA of human umbilical vein endothelial cells (HUVEC) stimulated with either the main trigger of angiogenesis, VEGF or a more general mitogenic growth factor, EGF. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS3568 GDS3570

Platforms:

GPL97 GPL96

14 Samples

Download data: CEL, CHP

Analysis of umbilical vein endothelial cells (HUVEC) treated with VEGF-A for up to 6 hours in vitro. VEGF-A is a major trigger of vasculogenesis and physiologic angiogenesis. Results provide insight into the molecular mechanisms underlying the vasculogenic and angiogenic activity of VEGF-A.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 5 time sets

Platform:

GPL97

Series:

GSE10778

5 Samples

Download data: CEL, CHP

Analysis of umbilical vein endothelial cells (HUVEC) treated with VEGF-A or EGF for up to 6 hours. VEGF-A is a major trigger of vasculogenesis and angiogenesis. EGF is a general growth factor. Results provide insight into the mechanisms underlying the vasculogenic and angiogenic activity of VEGF-A.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent, 5 time sets

Platform:

GPL96

Series:

GSE10778

9 Samples

Download data: CEL, CHP

Analysis of umbilical vein endothelial cells (HUVEC) treated with VEGF-A for up to 150 minutes in vitro. VEGF-A is a major trigger of vasculogenesis and physiologic angiogenesis. Results provide insight into the molecular mechanisms underlying the vasculogenic and angiogenic activity of VEGF-A.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 4 time sets

Platform:

GPL570

Series:

GSE15464

4 Samples

Download data: CEL, CHP

(Submitter supplied) Formation of blood vessels requires the concerted regulation of an unknown number of genes in a spatial-, time- and dosage-dependent manner. We investigated vascular development in vivo by determining global gene regulation throughout the formation of the chick chorio-allantoic membrane (CAM). Our study provides a comprehensive molecular map of vascular maturation during developmental angiogenesis and might thus be a valuable resource to streamline further research of candidates susceptible to mediate pathological angiogenesis.

Organism:

Gallus gallus

Type:

Expression profiling by array

Platform:

GPL3213

12 Samples

Download data: CEL, CHP