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Links from GEO DataSets

Items: 20

1.
Full record GDS1924

ErbB2/Neu and luteinizing hormone overexpression effect on the mammary gland: time course

Analysis of mammary glands of 5 and 10-week-old bitransgenics overexpressing oncogenic ErbB2/Neu and luteinizing hormone (LH). Results provide insight into the effect of chronic trophic maintenance of the mammary epithelial cells, induced by LH, on ErbB2/Neu-initiated tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL1261
Series:
GSE3501
6 Samples
Download data
2.

Comparative analysis of 10 week and 5 week Bitransgenic mice (LH mouse crossed with MMTV-neu mouse)

(Submitter supplied) To identify genes that may facilitate early steps of ErbB2/Neu-mediated mammary tumorigenesis, we performed comparative microarray analysis of 5- and 10-week bitransgenic mammary glands (LHxMMTV-neu) in triplicate. Keywords: transgenic mouse, erbB2, MMTV-neu, HER2, mammary tumor, breast cancer
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1924
Platform:
GPL1261
6 Samples
Download data
Series
Accession:
GSE3501
ID:
200003501
3.

Comparative Analysis of MMTV-neu tumors, preneoplastic MMTV-neu mammary gland, and Wild-type controls

(Submitter supplied) To identify early events of erbB2-induced mammary tumorigenesis, we compared datasets from 14 genechip experiments including MMTV-neu tumors, preneoplastic neu mammary gland (adjacent neu), and age-matched, wild-type control mammary glands Keywords = transgenic mouse Keywords = MMTV-neu Keywords = erbB2 Keywords = HER2 Keywords = mammary tumor Keywords: ordered
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1222
Platform:
GPL81
14 Samples
Download data
Series
Accession:
GSE2528
ID:
200002528
4.
Full record GDS1222

Mammary tumorigenesis in MMTV-neu model

Analysis of cancer progression by profiling of preneoplastic mammary glands and tumors of MMTV-neu animals. Activated neu allele placed under the control of mammary tumor virus promoter to enable mammary specific expression. Results provide insight into the early events of Neu induced tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 disease state, 2 genotype/variation sets
Platform:
GPL81
Series:
GSE2528
14 Samples
Download data
5.

The new multi-targeted agent Curaxin-137 suppresses mammary tumorigenesis in Her2/neu transgenic mice

(Submitter supplied) Global gene expression profiles in liver and spleen between Curaxin-treated and control mice
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
11 Samples
Download data: TXT
Series
Accession:
GSE33285
ID:
200033285
6.

Genomic aberrations in MMTV-cdc25a;MMTV-neu murine cell line

(Submitter supplied) CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumorigenesis induced by expression of ras or neu. CDC25A- overexpressing tumors display aggressiveness and genomic instability with changes in fragile chromosomal regions, including the region orthologous to human 1p32-36. more...
Organism:
Mus musculus
Type:
Genome variation profiling by genome tiling array
Platform:
GPL2884
2 Samples
Download data
Series
Accession:
GSE4767
ID:
200004767
7.

Gene expression changes resulting from cdc25a over-expression

(Submitter supplied) CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumorigenesis induced by expression of ras or neu. CDC25A- overexpressing tumors display aggressiveness and genomic instability with changes in fragile chromosomal regions, including the region orthologous to human 1p32-36. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2872
4 Samples
Download data: TXT
Series
Accession:
GSE4114
ID:
200004114
8.

ChIP-seq of Tcfap2c in Neu mammary cancer cells

(Submitter supplied) Tumors were harvested from mice carrying the rat activated Neu-oncogene and made into a single cell suspension. ChIP-SEQ was carried out as previously described in Kulak MV, Cyr AR, Woodfield GW, Bogachek M, Spanheimer PM, Li T et al. Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer. Oncogene 2013; 32: 4043-4051. Tcfap2c and RNA Pol II peaks can be found on their respective tracks.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9250
2 Samples
Download data: WIG
Series
Accession:
GSE61394
ID:
200061394
9.

Transcriptional Regulation of the GPX1 Gene by TFAP2C and Aberrant CpG Methylation in Human Breast Cancer

(Submitter supplied) The complexity of gene regulation has created obstacles to defining mechanisms that establish the patterns of gene expression characteristic of the different clinical phenotypes of breast cancer. Transcription factor TFAP2C plays a critical role in the regulation of both estrogen receptor-alpha (ERα) and c-ErbB2/HER2 (Her2). Herein, we performed chromatin immunoprecipitation and direct sequencing (ChIP-seq) for TFAP2C in four breast cancer cell lines representing different clinical phenotypes. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9052
4 Samples
Download data: WIG
Series
Accession:
GSE36351
ID:
200036351
10.

Distinct ErbB-2-coupled signalling pathways promote mammary tumors with unique pathological and transcriptional profiles

(Submitter supplied) ErbB-2 overexpression and amplification occurs in 15 - 30% of human invasive breast carcinomas associated with poor clinical prognosis. Previously, we have demonstrated that four ErbB-2/Neu tyrosine-autophosphorylation sites within the cytoplasmic tail of the receptor recruit distinct adaptor proteins and are sufficient to mediate transforming signals in vitro. Two of these sites representing the Grb2 (Neu-YB) and Shc (Neu-YD) binding sites can induce mammary tumourigenesis and metastasis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2872
12 Samples
Download data: TXT
Series
Accession:
GSE7595
ID:
200007595
11.

Changes in Gene expression during the development and progression of mammary tumors in MMTV-Wnt-1 and MMTV-Neu TG mice

(Submitter supplied) Gene expression profiling of samples from normal virgin mammary glands, hyperplastic mammary glands, mamary tumors, and lung metastases from MMTV-Wnt-1 transgenic (TG) mice, and mammary tumors and lung metastases from MMTV-Neu trangenic (TG) mice Keywords: Array analysis, multi-step tumorigenesis, metastasis, MMTV-Wnt-1 trangenic mice, MMTV-Neu transgenic mice
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL1511 GPL1512
84 Samples
Download data
Series
Accession:
GSE2860
ID:
200002860
12.

Gene expression from ErbB2KI tumors with a heterozygous or a homoszygous loss of beta-catenin (ctnnb1)

(Submitter supplied) Beta-catenin controls both cell adhesion and transcription to facilitate ErbB2-driven mammary tumorigenesis In this study, we used conditional knockout and gene expression approaches to understand global molecular and transciptional changes due to ablation of both functions of beta-catenin.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
15 Samples
Download data: CEL, CHP
Series
Accession:
GSE89498
ID:
200089498
13.

Effect of Spot14 Loss on Gene Expression Profile of MMTV-PyMT Mouse Tumors

(Submitter supplied) The objective of this study was to determine the effect of Thyroid Hormone Responsive Protein Spot14 (Spot14) loss on the gene expression profiles of tumors from MMTV-Polyomavirus middle-T antigen (PyMT) mice. MMTV-PyMT/S14-heterozygous mice were crossed with S14-heterozygous mice and 1 cm tumors from MMTV-PyMT control (wild-type S14) or MMTV-PyMT/S14-null offspring were profiled using Affymetrix gene arrays. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
8 Samples
Download data: CEL
Series
Accession:
GSE55886
ID:
200055886
14.

Effect of Spot14 Overexpression on Gene Expression Profile of MMTV-Neu Mouse Tumors

(Submitter supplied) The objective of this study was to determine the effect of Thyroid Hormone Responsive Protein Spot14 (Spot14) overexpression on the gene expression profiles of tumors from MMTV-Neu mice. Hemizygous MMTV-Neu and MMTV-Spot14 mice were bred and 1 cm tumors from Neu control or Neu/Spot14 bitransgenic offspring were profiled using Affymetrix gene arrays. Tumors from Neu/Spot14 mice emerged significantly earlier than controls, but expressed many genes associated with lactogenic differentiation and were not highly metastatic. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
22 Samples
Download data: CEL
Series
Accession:
GSE42708
ID:
200042708
15.

CGH analysis of mouse mammary gland tumors from eight genetically-engineered mouse models

(Submitter supplied) Background. Oncogene overexpression in primary cells often triggers the induction of a cellular safeguard response promoting senescence or apoptosis. Secondary cooperating genetic events are generally required for oncogene induced tumorigenesis to overcome these biologic obstacles. We employed array CGH for 8 genetically-engineered mouse models of mammary cancer to identify loci that might harbor genes that enhance oncogene-induced tumorigenesis. more...
Organism:
Mus musculus
Type:
Genome variation profiling by array
Platform:
GPL11288
45 Samples
Download data: TXT
Series
Accession:
GSE75331
ID:
200075331
16.

Comprehensive genomic profiling identified miRNA signatures associated with mammary tumor differentiation and development

(Submitter supplied) We performed affymetrix gene expression profiling on mammary tumors from eight well-characterized genetically engineered Mouse (GEM) models of human breast cancer. The gene expression data will be combined with the miRNA gene expression data from the corresponding mammary tumors and tissues for integrated miRNA and mRNA gene expression analysis, which are useful in improving the identification of miRNA targets from potential targets identified in silico.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4077
Platform:
GPL8321
46 Samples
Download data: CEL
Series
Accession:
GSE23938
ID:
200023938
17.
Full record GDS4077

Genetically engineered murine models of human breast cancer

Analysis eight well-characterized genetically engineered mouse (GEM) models of human breast cancer , including MMTV-H-Ras, -Her2/neu, -c-Myc, -PymT, -Wnt1 and C3(1)/SV40 T/t-antigen transgenic mice, BRCA1(fl/fl);p53(+/-);MMTV-cre knock-out mice and the p53(fl/fl);MMTV-cre transplant model.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 9 genotype/variation, 3 strain, 2 tissue sets
Platform:
GPL8321
Series:
GSE23938
46 Samples
Download data: CEL
18.

Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet in P53 -/- mice

(Submitter supplied) Gene expression for genes differentially expressed between early vs. late tumor onset and high fat diet (HFD) vs. low fat diet (LFD) in P53 -/- mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
41 Samples
Download data: TXT
Series
Accession:
GSE74294
ID:
200074294
19.

Genomic Profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage (primary tumors and normal mammary glands)

(Submitter supplied) MicroRNAs (miRNAs) are small, non-coding, endogenous RNAs involved in many human diseases including breast cancer. miRNA expression profiling of human breast cancers has identified miRNAs related to the clinical diversity of the disease and potentially provides novel diagnostic and prognostic tools for breast cancer therapy. In order to further understand the roles of miRNAs in association with oncogenic drivers and in specifying sub-types of breast cancer, we performed miRNAexpression profiling on mammary tumors from eight well-characterized genetically -engineered Mouse (GEM) models of human breast cancer including MMTV–H-Ras, -Her2/neu, -c-Myc, -PymT, –Wnt1 and C3(1)/SV40 T/t-antigen transgenic mice, BRCA1fl/fl;p53+/-;MMTV-cre and the p53fl/fl ;MMTV-cre transplant model.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL10880
46 Samples
Download data: TXT
Series
Accession:
GSE23978
ID:
200023978
20.

Genomic Profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage (mammary normal and tumors in different mice strains)

(Submitter supplied) MicroRNAs (miRNAs) are small, non-coding, endogenous RNAs involved in many human diseases including breast cancer. miRNA expression profiling of human breast cancers has identified miRNAs related to the clinical diversity of the disease and potentially provides novel diagnostic and prognostic tools for breast cancer therapy. In order to further understand the roles of miRNAs in association with oncogenic drivers and in specifying sub-types of breast cancer, we performed miRNAexpression profiling on mammary tumors from eight well-characterized genetically -engineered Mouse (GEM) models of human breast cancer including MMTV–H-Ras, -Her2/neu, -c-Myc, -PymT, –Wnt1 and C3(1)/SV40 T/t-antigen transgenic mice, BRCA1fl/fl;p53+/-;MMTV-cre and the p53fl/fl ;MMTV-cre transplant model. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL10880
11 Samples
Download data: TXT
Series
Accession:
GSE23977
ID:
200023977
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