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Links from GEO DataSets

Items: 20

1.
Full record GDS1941

Cystic fibrosis transmembrane conductance regulator deficiency in different genetic backgrounds

Analysis of lungs of C57BL/6J (B6) or BALB/c (BALB) animals deficient for cystic fibrosis transmembrane conductance regulator (CFTR). B6 background animals have a higher propensity to develop CF lung disease. Results suggest the variable severity of CF is controlled by multiple genetic factors.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 gender, 2 genotype/variation, 2 strain sets
Platform:
GPL1261
Series:
GSE3100
23 Samples
Download data: CEL
DataSet
Accession:
GDS1941
ID:
1941
2.

Cystic Fibrosis Mouse Lung Profiles

(Submitter supplied) Gene expression profiling with microarrays was used to identify genes differentially expressed in the lungs of B6 and BALB CF mice compared to non-CF littermates Keywords: disease state analysis
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1941
Platform:
GPL1261
23 Samples
Download data: CEL
Series
Accession:
GSE3100
ID:
200003100
3.

Intestinal Phenotype of Variable Weight Cystic Fibrosis Knockout Mice

(Submitter supplied) Cystic fibrosis transmembrane conductance regulator (Cftr) knockout mice present the clinical features of low body weight and intestinal disease permitting an assessment of the interrelatedness of these phenotypes in a controlled environment. To identify intestinal alterations which affect body weight in CF mice the histological phenotypes of crypt-villus axis height, goblet cell hyperplasia, and mast cell infiltrate were measured, cardiac blood samples assessed, and gene expression profiling of the ileum was completed for 12 week old (C57BL/6xBALB) F2 Cftrtm1UNC and non-CF mice presenting a range of body weight. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
10 Samples
Download data: CEL
Series
Accession:
GSE5715
ID:
200005715
4.

strain dependent pulmonary bleomycin response

(Submitter supplied) right lung gene expression of C57BL/6J, A/J and C3H/HeJ mice following bleomcyin exposure Keywords: other
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1492
Platform:
GPL339
21 Samples
Download data
Series
Accession:
GSE2640
ID:
200002640
5.
Full record GDS1492

Bleomycin effect on lungs: dose response and time course

Comparison of lungs from C57BL/6J and C3H/HeJ strains, 3 and 6 weeks after treatment with 80, 100, or 125 units of bleomycin/kg. C57BL/6Js are susceptible to bleomycin-induced pulmonary fibrosis, while C3H/HeJs are resistant. Results identify candidate genes underlying fibrosis susceptibility.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 4 dose, 2 gender, 2 other, 3 strain, 3 time sets
Platform:
GPL339
Series:
GSE2640
21 Samples
Download data
6.

MicroRNA profiling of cystic fibrosis intestinal disease in mice

(Submitter supplied) Cystic fibrosis (CF) intestinal disease is characterized by alterations in processes such as proliferation and apoptosis which are known to be regulated in part by microRNA’s. Herein, we completed microRNA expression profiling of the intestinal tissue from the cystic fibrosis mouse model of cystic fibrosis transmembrane conductance regulator (Cftr) deficient mice (BALBc/J Cftrtm1UNC), relative to that of wildtype littermates, to determine whether changes in microRNA expression level are part of this phenotype. more...
Organism:
Mus musculus; Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Human alphaherpesvirus 1; Macaca mulatta polyomavirus 1; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Homo sapiens; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
15 Samples
Download data: TXT
Series
Accession:
GSE19621
ID:
200019621
7.

Influence of CFTR on Lipid Metabolism Gene Expression in Marrow Derived Dendritic Cells infected with P. aeruginosa

(Submitter supplied) Dysfunction of the cystic fibrosis transmembrane regulator (CFTR) in cystic fibrosis (CF) results in exaggerated and chronic inflammation as well as increased susceptibility to chronic pulmonary infections, in particular with Pseudomonas aeruginosa. Based on the concept that host immune responses do not seem to be adequate to eradicate P.aeruginosa from the lungs of CF patients and that dendritic cells (DC) play an important role in initiating and shaping adaptive immune responses, this study analyzed the role of CFTR in bone marrow-derived murine DC from CFTR knockout (CF) mice with and without exposure to P.aeruginosa. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
24 Samples
Download data: CEL
Series
Accession:
GSE9488
ID:
200009488
8.

Expression data of cystic fibrosis and non-cystic fibrosis airway cell lines under oxidative stress

(Submitter supplied) CF's physiopathology is poorly explained by the mutation alone. The oxydative stress could be a major factor of this illness . Study its impact on transcriptome's CF cell line could be ameliorate our understanding of the evolution of cystic fibrosis. we used microarray technology to evaluate under oxydative stress, the transcriptional state of an epithelial lung cell issued from a human with cystic fibrosis and to identify a set of modulated genes associated to survival cell processes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
12 Samples
Download data: CEL
Series
Accession:
GSE39843
ID:
200039843
9.

Expression Profiling of DA, COP, and F1(COPxDA) rat left ventricles

(Submitter supplied) We used high density oligonucleotide arrays to measure the relative expression levels of ~27,000 probe sets in the left ventricles of inbred rat strains; DA (high performing), Copenhagen (COP, low performing), as well as F1(COPxDA) rats bred from these two strains whose performance was intermediate relative to both parental strains. DA and COP rats differ for both intrinsic aerobic running capacity (assessed with a treadmill exercise test to exhaustion) and intrinsic cardiac performance (as assessed by the Langendorff-Neeley working heart model). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS778 GDS779 GDS780
Platforms:
GPL86 GPL87 GPL85
36 Samples
Download data
Series
Accession:
GSE1795
ID:
200001795
10.
Full record GDS780

Aerobic running capacity: expression profiling of heart ventricles from various strains (RG-U34C)

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 strain sets
Platform:
GPL87
Series:
GSE1795
12 Samples
Download data
DataSet
Accession:
GDS780
ID:
780
11.
Full record GDS779

Aerobic running capacity: expression profiling of heart ventricles from various strains (RG-U34B)

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 strain sets
Platform:
GPL86
Series:
GSE1795
12 Samples
Download data
DataSet
Accession:
GDS779
ID:
779
12.
Full record GDS778

Aerobic running capacity: expression profiling of heart ventricles from various strains (RG-U34A)

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 strain sets
Platform:
GPL85
Series:
GSE1795
12 Samples
Download data
DataSet
Accession:
GDS778
ID:
778
13.

Mouse ventilator-induced lung injury experiment

(Submitter supplied) Gene expression analysis of BALB/c mouse lung tissue following LPS, high pressure ventilation and LPS+high pressure ventilation treatment Keywords: VILI, gene expression profiling, ARDS
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL3436
26 Samples
Download data: TXT
Series
Accession:
GSE4215
ID:
200004215
14.

General Electric/Amersham Biosciences Mouse CodeLink 10K and 20K arrays

(Submitter supplied) CODELINK 10 and 20K mouse cRNA arrays
Organism:
Mus musculus
1 Series
26 Samples
Download data
Platform
Accession:
GPL3436
ID:
100003436
15.

Codelink Uniset Mouse-1 Array Platform

(Submitter supplied) GE (formerly Amersham Biosciences) CODELINK UNISET MOUSE-1 (10K) array expression data
Organism:
Mus musculus
1 DataSet
2 Series
45 Samples
Download data
Platform
Accession:
GPL2026
ID:
100002026
16.

Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line

(Submitter supplied) Most individuals with cystic fibrosis (CF) carry one or two mutations that result in a maturation defect of the full-length CFTR protein. The deltaF508 mutation results in a mutant protein that is degraded by the proteasome instead of progressing to the apical membrane where it functions as a cyclic AMP-regulated chloride channel. 4 phenylbutyrate modulates heat shock protein expression and promotes trafficking of deltaF508 thus permitting maturation and membrane insertion. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS493 GDS494
Platforms:
GPL96 GPL97
22 Samples
Download data: CEL
Series
Accession:
GSE620
ID:
200000620
17.
Full record GDS494

Cystic fibrosis pathology and 4-phenylbutyrate (HG-U133B)

Effect of 1mM 4-phenylbutyrate (PBA) at 0, 12 and 24 hours in cystic fibrosis bronchial epithelial model cell line IB3-1. PBA modulates heat shock protein and promotes trafficking of deltaF508 cystic fibrosis transmembrane conductance regulator (CFTR).
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 time sets
Platform:
GPL97
Series:
GSE620
11 Samples
Download data: CEL
DataSet
Accession:
GDS494
ID:
494
18.
Full record GDS493

Cystic fibrosis pathology and 4-phenylbutyrate (HG-U133A)

Effect of 1mM 4-phenylbutyrate (PBA) at 0, 12 and 24 hours in cystic fibrosis bronchial epithelial model cell line IB3-1. PBA modulates heat shock protein and promotes trafficking of deltaF508 cystic fibrosis transmembrane conductance regulator (CFTR).
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 time sets
Platform:
GPL96
Series:
GSE620
11 Samples
Download data: CEL
DataSet
Accession:
GDS493
ID:
493
19.

Control vs CF Small Intestine

(Submitter supplied) Total RNA was prepared from the entire small intestines of 40 day old Control and CFTR null mice (2 males and 1 female of each genotype), congenic on the black6 background, using TRIzol reagent. Mice were fed Peptamen from age 10 days to prevent intestinal obstruction. Keywords: parallel sample
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS588
Platform:
GPL81
6 Samples
Download data: CEL
Series
Accession:
GSE765
ID:
200000765
20.
Full record GDS588

Cystic fibrosis and small intestine

Analysis of small intestine from 40 day old CFTR-/- and CFTR+/+ mice. The CFTR null mouse has a severe intestinal phenotype serving as model for cystic fibrosis related growth deficiency, meconium ileus, and distal intestinal obstructive syndrome.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL81
Series:
GSE765
6 Samples
Download data: CEL
DataSet
Accession:
GDS588
ID:
588
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