GEO DataSets

(Submitter supplied) Summary: Spinal cord injury (SCI) is a damage to the spinal cord induced by trauma or desease resulting in a loss of mobility or feeling. SCI is characterized by a primary mechanical injury followed by a secondary injury in which several molecular events are altered in the spinal cord often resulting in loss of neuronal function. Hypothesis: Spinal cord injury (SCI) induces a cascade of molecular events including the activation of genes associated with transcription factors, inflammation, oxidative stress, ionic imbalance, apoptosis and neuroregeneration which suggests the existance of endogenous reparative attempts. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS63 GDS259 GDS339 GDS869 GDS870 GDS871 GDS872 GDS873 GDS874

Platforms:

GPL86 GPL85 GPL87

544 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord above thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 protocol, 7 time sets

Platform:

GPL87

Series:

GSE464

48 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord above thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 protocol, 7 time sets

Platform:

GPL86

Series:

GSE464

47 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord above thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 protocol, 7 time sets

Platform:

GPL85

Series:

GSE464

52 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord below thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 protocol, 6 time sets

Platform:

GPL87

Series:

GSE464

43 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord below thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 protocol, 7 time sets

Platform:

GPL86

Series:

GSE464

52 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord below thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 protocol, 7 time sets

Platform:

GPL85

Series:

GSE464

55 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord at thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 protocol, 11 time sets

Platform:

GPL87

Series:

GSE464

75 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord at thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 protocol, 11 time sets

Platform:

GPL86

Series:

GSE464

77 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord at thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 protocol, 11 time sets

Platform:

GPL85

Series:

GSE464

89 Samples

Download data: CEL

(Submitter supplied) The application of mechanical insults to the spinal cord results in profound cellular and molecular changes, including the induction of neuronal cell death and altered gene expression profiles. We demonstrated that spinal cord cells undergo cell death in response to cyclic tensile stresses, which were dose- and time- dependent. In addition, we have identified the up regulation of various genes, in particular of the MAPK pathway, which may be involved in this cellular response. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

7 Samples

Download data: CEL, CHP