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Links from GEO DataSets

Items: 20

1.

Comparative molecular analysis of developing mouse forelimbs and hindlimbs

(Submitter supplied) The analysis of differentially expressed genes is a powerful approach to elucidate the genetic mechanisms underlying the morphological and evolutionary diversity among serially homologous structures, both within the same organism (e.g., hand vs. foot) and between different species (e.g., hand vs. wing). In the developing embryo, limb-specific expression of Pitx1, Tbx4, and Tbx5 regulates the determination of limb identity. more...
Organism:
Mus musculus
Type:
Expression profiling by SAGE
Platform:
GPL11
2 Samples
Download data
Series
Accession:
GSE504
ID:
200000504
2.

A SAGE approach to discovery of apolipoprotein E4 allele-specific genes involved in increased risk in Alzheimer disease

(Submitter supplied) APOE4 allele is a major risk factor for late-onset Alzheimer disease (AD). The mechanism of action of APOE in AD remains unclear. To study the effects of APOE alleles on gene expression in AD, we have analyzed the gene transcription patterns of human hippocampus from APOE3/3, APOE3/4, APOE4/4 AD patients and normal control using Serial Analysis of Gene Expression (SAGE). Using SAGE, we found gene expression patterns in hippocampus of APOE3/4 and APOE4/4 AD patients differ substantially from those of APOE3/3 AD patients. more...
Organism:
Homo sapiens
Type:
Expression profiling by SAGE
Platforms:
GPL4 GPL1485
6 Samples
Download data
Series
Accession:
GSE6677
ID:
200006677
3.

Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements

(Submitter supplied) Extensive functional analyses have demonstrated that the pituitary homeodomain transcription factor Pitx1 plays a critical role in specifying hindlimb morphology in vertebrates. However, much less is known regarding the target genes and cis-regulatory elements through which Pitx1 acts. Earlier studies suggested that the hindlimb transcription factors Tbx4, HoxC10, and HoxC11 might be transcriptional targets of Pitx1, but definitive evidence for direct regulatory interactions has been lacking. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11002 GPL13112
4 Samples
Download data: BED, WIG
Series
Accession:
GSE41591
ID:
200041591
4.

Regulatory integration of Hox factor action with Tbox factors in limb development

(Submitter supplied) Hindlimb and Forelimb-specific Tbox factors integrates their mode of action with distinct Hox factors resulting in different transcriptional outcomes. In addition, hindlimb-specific Tbx4, Hoxc10 and Pitx1 act on the same platform to target common putative downstream genes for hindlimb development
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
3 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE104398
ID:
200104398
5.

Pitx1 directly controls the core limb development program to implement hindlimb identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21103 GPL13112
36 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE100734
ID:
200100734
6.

Pitx1 directly controls the core limb development program to implement hindlimb identity [ChIP-Seq]

(Submitter supplied) Pitx1, critical regulator of a limited hindlimb-specific gene network, targets the limb development program common to both fore- and hindlimbs in order to implement hindlimb-specific limb morphology.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL13112 GPL21103
18 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE100728
ID:
200100728
7.

Pitx1 directly controls the core limb development program to implement hindlimb identity [RNA-Seq]

(Submitter supplied) Pitx1, critical regulator of a limited hindlimb-specific gene network, targets the limb development program common to both fore- and hindlimbs in order to implement hindlimb-specific limb morphology.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
18 Samples
Download data: TXT
Series
Accession:
GSE100727
ID:
200100727
8.

HOX13 activity reprograms cis-regulatory modules during digit development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
17 Samples
Download data: BED, TXT
Series
Accession:
GSE81358
ID:
200081358
9.

HOX13 activity reprograms cis-regulatory modules during digit development (RNA-Seq)

(Submitter supplied) The combinatorial expression of the Hox genes along the body axes, referred to as the HOX code, is a major determinant of cell fate and plays a prevailing role in generating the animal body plan. In developing limb buds, the paralogous group 13 genes of the HoxA and HoxD clusters are essential for patterning the distal-most limb structures, the digits. Inactivation of HOXA13 and HOXD13 transcription factors (HOX13) leads to complete digit agenesis in mice, but how HOX13 regulate transcriptional outcomes and confer identity to the distal-most limb cells has remained elusive. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
5 Samples
Download data: TXT
Series
Accession:
GSE81357
ID:
200081357
10.

HOX13 activity reprograms cis-regulatory modules during digit development (ChIP-Seq)

(Submitter supplied) The combinatorial expression of the Hox genes along the body axes, referred to as the HOX code, is a major determinant of cell fate and plays a prevailing role in generating the animal body plan. In developing limb buds, the paralogous group 13 genes of the HoxA and HoxD clusters are essential for patterning the distal-most limb structures, the digits. Inactivation of HOXA13 and HOXD13 transcription factors (HOX13) leads to complete digit agenesis in mice, but how HOX13 regulate transcriptional outcomes and confer identity to the distal-most limb cells has remained elusive. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
12 Samples
Download data: BED
Series
Accession:
GSE81356
ID:
200081356
11.

Shifts in pigeon limb identity reveal conserved genetic networks

(Submitter supplied) The goal of this study is to identify genetic network changes that accompany shifts in limb identity.
Organism:
Anolis sagrei
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26286
10 Samples
Download data: TXT
Series
Accession:
GSE128151
ID:
200128151
12.

Shifts in pigeon limb identity reveal conserved genetic networks

(Submitter supplied) In feather-footed pigeons, mutant alleles of PITX1 and TBX5 drive the partial redeployment of an evolutionarily conserved forelimb genetic program in the hindlimb.
Organism:
Columba livia; Gallus gallus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19005 GPL22642
96 Samples
Download data: CSV, TXT
Series
Accession:
GSE127775
ID:
200127775
13.

Somatic cells in testes

(Submitter supplied) Gene expression profiles of somatic cells of fetal and adult testis. To identify genes developmentally regulated in the somatic cells of the testis, serial analysis of gene expression (SAGE) has been used to generate gene expression profiles from these cells in the fetal and adult mouse. To avoid germ cell transcripts, a fetal SAGE library was generated from germ cell-free fetal Wv/Wv mice, and an adult SAGE library was generated from adult testes depleted of germ cells with busulfan. more...
Organism:
Mus musculus
Type:
Expression profiling by SAGE
Platform:
GPL11
2 Samples
Download data
Series
Accession:
GSE366
ID:
200000366
14.

Digital gene expression tag profiling of digit morphologies in bats

(Submitter supplied) As the only truly flying mammals, bats use their unique wing formed from elongated digits connected by membranes to power their flight. The forelimb of bats consists of four elongated digits (digits II-V) and one shorter digit (digit I) that is morphologically similar to the hindlimb digits. Elongation of bat forelimb digits is thought to results from changes in the temporal and spatial expression of a number of developmental genes. more...
Organism:
Myotis ricketti
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15028
3 Samples
Download data
Series
Accession:
GSE20038
ID:
200020038
15.

SAGE tags generated from Triticum aestivum cultivars Scorpion 25 and Xi19 grown under normal and hot/dry conditions

(Submitter supplied) Triticum aestivum cultivars Scorpion 25 and Xi 19 were grown under both normal and hot/dry conditions. We compared the effect of these two growth conditions on these two closely related varieties.
Organism:
Triticum aestivum
Type:
Expression profiling by SAGE
Platform:
GPL7079
6 Samples
Download data
Series
Accession:
GSE12832
ID:
200012832
16.

Adult mouse testis

(Submitter supplied) SAGE libraries generated from total testes of adult mouse males. Keywords = testis Keywords: other
Organism:
Mus musculus
Type:
Expression profiling by SAGE
Platform:
GPL11
2 Samples
Download data
Series
Accession:
GSE1939
ID:
200001939
17.

Bombyx mori Posterior and Median Silk Gland SAGE transcriptome

(Submitter supplied) To identify functions that distinguish the posterior and median cells producing fibroin and sericin in the silk gland of Bombyx mori, serial analysis of gene expression (SAGE) profiles from both silk gland regions were analyzed and compared. The construction of a B. mori reference tag collection extracted from a set of 38000 Bombyx EST sequenced from the 3’ side, helped annotating the SAGE libraries. more...
Organism:
Bombyx mori
Type:
Expression profiling by SAGE
Platform:
GPL2095
2 Samples
Download data
Series
Accession:
GSE23098
ID:
200023098
18.

Skeletal muscle of glucocorticoid deprived and treated mice by SAGE

(Submitter supplied) Forty male C57BL6 mice 12-15 weeks old fed chow ad libitum. 30 mice underwent adrenalectomy (Adx) and 10 others a sham-Adx. Three or 24 h before tissue sampling, groups of 10 mice received an I.P. injection of cortisol (0.1 mg per mice), while the remaining Adx and intact mice received an I.P. injection of the vehicle (ethanol) 24 h prior to the sacrifice. All mice were killed within a period of a few hours. more...
Organism:
Mus musculus
Type:
Expression profiling by SAGE
Platform:
GPL11
4 Samples
Download data
Series
Accession:
GSE2122
ID:
200002122
19.

Skeletal muscle of adrenalectomized mice with and without a glucocorticoid injection 3 or 24 h previously (MG-U74Av2)

(Submitter supplied) Forty male C57BL6 mice 12-15 weeks old fed chow ad libitum. 30 mice underwent adrenalectomy (Adx) and 10 others a sham-Adx. Three or 24h before tissue sampling, groups of 10 mice received an I.P. injection of cortisol (0.1 mg per mice), while the remaining Adx and intact mice received an I.P. injection of the vehicle (ethanol) 24 h prior to the sacrifice. All mice were killed within a period of a few hours. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1862
Platform:
GPL81
4 Samples
Download data: CEL, EXP
Series
Accession:
GSE2121
ID:
200002121
20.
Full record GDS1862

Adrenalectomized mice skeletal muscle response to cortisol: time course (MG-U74A)

Expression profiling of gastrocnemius muscle of adrenalectomized C57BL6 males at 3 and 24 hours following intraperitoneal injection of cortisol. Results compared with those from SAGE (GSE2122) to assess the reproducibility of SAGE experiments.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 protocol, 3 time sets
Platform:
GPL81
Series:
GSE2121
4 Samples
Download data: CEL, EXP
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