GEO DataSets

(Submitter supplied) Genes regulated by inflammatory cytokines in five primary endothelial cell types Keywords: ordered

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS498 GDS499 GDS501 GDS502

Platform:

GPL371

15 Samples

Download data

Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary colon endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

Download data

Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary dermal endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

Download data

Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary aortic endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

Download data

Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary lung endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

Download data

(Submitter supplied) HUVEC were left untreated or stimulated for 5h with 2 ng/ml TNF. Comparsion of the gene profiles revealed TNF-mediated gene expression changes in HUVEC. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1542

Platform:

GPL96

8 Samples

Download data: CEL, EXP

(Submitter supplied) HMEC cultures were left untreated or stimulated for 5h with 2 ng/ml TNF. Comparison of the gene expression profiles revealed the TNF-mediated gene expression changes. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1543

Platform:

GPL96

6 Samples

Download data: CEL, EXP

Analysis of microvascular endothelial cells (HMEC) stimulated with tumor necrosis factor (TNF)-alpha for 5 hours. TNF is a potent inflammatory stimulus. Results provide insight into the relevance of the diversity of endothelial cell subtypes for the response to inflammatory stimuli.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL96

Series:

GSE2638

6 Samples

Download data: CEL, EXP

Analysis of macrovascular umbilical vein endothelial cells (HUVEC) stimulated with tumor necrosis factor (TNF)-alpha for 5 hours. TNF is a potent inflammatory stimulus. Results provide insight into the relevance of the diversity of endothelial cell subtypes for the response to inflammatory stimuli.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL96

Series:

GSE2639

8 Samples

Download data: CEL, EXP

(Submitter supplied) Response to allergen was studied in bronchial epithelial cell line H292. Cells were cultured and subsequently exposed to House dust mite or vessel (saline) Microarray data was analysed using bioinformatics and biostastics. We find a strong response to allergen in epithelial cells Keywords: cellular response to allergen

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3003

Platform:

GPL570

6 Samples

Download data: CEL, EXP

Analysis of H292 bronchial epithelial cells exposed to house dust mite (HDM) extract. More than just a physical barrier, epithelium can produce mediators in response to pathogens and allergens. Results provide insight into the nature of the response of bronchial epithelial cells to HDM allergen.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL570

Series:

GSE9151

6 Samples

Download data: CEL, EXP

(Submitter supplied) RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone. Keywords = interferon gamma Keywords = dexamethasone Keywords = human bronchial epithelial cells Keywords: dose response

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1256

Platform:

GPL8300

36 Samples

Download data

Analysis of bronchial epithelial cells treated with interferon (IFN) gamma, or dexamethasone (dex), or both. IFN-gamma plays a role in lung inflammatory responses and corticosteroids such as dex are used as treatments for inflammation. Cells examined 8 or 24 hours after treatment.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 agent, 2 time sets

Platform:

GPL8300

Series:

GSE1815

36 Samples

Download data

(Submitter supplied) Activation of the vascular endothelium with cytokines such as TNF is widely used to study the role of the vasculature in proinflammatory disease. To gain insight into mechanisms of prolonged vascular endothelial activation we compared changes in gene expression induced by continuous activation in stable tmTNFalpha expressing cells with changes due to acute TNFalpha challenge in vitro. Affymetrix Genechip® analysis was performed on RNA from control, acute and continuous TNFalpha-activated endothelial cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2773

Platform:

GPL1261

12 Samples

Download data

Analysis of endothelial cells acutely activated by treatment with soluble tumor necrosis factor (TNF) or chronically activated by expression of an uncleavable form of the transmembrane TNF precursor. Results provide insight into the mechanisms mediating the effect of chronic endothelial activation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL1261

Series:

GSE4518

12 Samples

Download data

(Submitter supplied) Specific Aims To identify novel transcriptional events associated with angiogenesis in VEGF and Ang-1 stimulated rat aortic rings. Our studies take advantage of the capacity of rat aortic rings to generate new vessels in collagen gels. Rat aortic rings embedded in collagen gel immediately after excision from the animal produce a self-limited angiogenic response under serum-free conditions and in the absence of exogenous stimuli. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS1922 GDS1923

Platforms:

GPL341 GPL342

18 Samples

Download data

Analysis of aortic rings treated with angiopoietin-1 (Ang-1) or vascular endothelial growth factor (VEGF). Aortic rings can generate neovessels ex vivo after angiogenic factor stimulation. Results identify transcriptional events associated with angiogenesis in VEGF and Ang-1 stimulated aortic rings.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL342

Series:

GSE3355

8 Samples

Download data

Analysis of aortic rings treated with angiopoietin-1 (Ang-1) or vascular endothelial growth factor (VEGF). Aortic rings can generate neovessels ex vivo after angiogenic factor stimulation. Results identify transcriptional events associated with angiogenesis in VEGF and Ang-1 stimulated aortic rings.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL341

Series:

GSE3355

9 Samples

Download data

(Submitter supplied) Clinical variability in sickle cell disease (SCD) suggests a role for extra-erythrocytic factors in the pathogenesis of vasoocclusion. We hypothesized that one potential factor, endothelial dysfunction, results from induction of phenotypic changes by circulating factors in SCD patients. The database reports gene expression in cultured human pulmonary artery endothelial cells (HPAEC) exposed to plasma from: a) sickle acute chest syndrome (ACS) patients (samples ; b) SCD patients at steady-state and c) normal volunteers using microarrays (U133A-B GeneChip Affymetrix). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS1257 GDS1258

Platforms:

GPL97 GPL96

65 Samples

Download data

Expression profiling of pulmonary artery endothelial cells exposed to plasma from sickle cell disease (SCD) patients with sickle acute chest syndrome or from SCD patients at steady state. Results provide insight into the role of extra-erythrocytic factors in sickle cell vasoocclusion.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL97

Series:

GSE1849

32 Samples

Download data