GEO DataSets

(Submitter supplied) Molecular definition of human extraocular muscles (EOM). Human EOM were compared with limb (quadriceps femoris) muscle. Keywords = Eye Keywords = EOM Keywords = Muscle Keywords = DMD Keywords = Myasthenia Gravis Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS525

Platform:

GPL96

5 Samples

Download data: CEL

Molecular definition of extraocular muscle (EOM). Autopsy superior rectus EOM compared with biopsy limb quadriceps femoris muscle.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL96

Series:

GSE873

5 Samples

Download data: CEL

(Submitter supplied) The extraocular muscles (EOM) are anatomically and physiologically distinct from other skeletal muscles. EOM are preferentially affected in mitochondrial myopathies, but spared in Duchenne's muscular dystrophy. The anatomical and pathophysiological properties of EOM have been attributed to their unique molecular makeup: an allotype. We used expression profiling to define molecular features of the EOM allotype. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS254

Platform:

GPL85

16 Samples

Download data: CEL

Molecular definition of extraocular muscles (EOM). EOM are anatomically and physiologically distinct from other skeletal muscles.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL85

Series:

GSE471

16 Samples

Download data: CEL

(Submitter supplied) Adult rat global and orbital layers of rectal extraocular muscles microdissected using Arcturus Pixcell II LCM are gene profiled here using affymetrix rat RAE230A gene chip. www.med.upenn.edu/cellbio/faculty/rubinstein/ www.uphs.upenn.edu/pmi/members/khurana/lab%20page.htm Keywords: ordered

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS851

Platform:

GPL341

8 Samples

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Expression profiling of microdissected global and orbital layers of the rectus extraocular muscle (EOM) from 2 adult Sprague-Dawleys. By identifying molecular differences between the 2 layers, results provide insight into the possible specialized function of each muscle layer.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL341

Series:

GSE1374

8 Samples

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(Submitter supplied) Conserved and muscle group-specific gene expression patterns shape postnatal development of the novel extraocular muscle phenotype. Comparison of postnatal development of extraocular and hindlimb muscle between birth and P45. Keywords: parallel sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS621

Platform:

GPL85

36 Samples

Download data: CEL

Analysis of hindlimb and extraocular muscle (EOM) between birth and postnatal day 45. Dissecting allotype-specific regulatory mechanisms may help explain differential muscle group sensitivity to a variety of metabolic and neuromuscular diseases.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 6 age, 2 tissue sets

Platform:

GPL85

Series:

GSE903

36 Samples

Download data: CEL

(Submitter supplied) Three subjects with Duchenne muscular dystrophy (8.3, 10.4, and 16.7 years old) were studied. Baseline studies included stable isotope infusion followed by gastrocnemius muscle biopsy to determine myosin heavy chain synthesis rates. RNA was isolated from the muscle biopsy as well. The subjects were then treated for 3 months with oxandrolone (a synthetic anabolic steroid, 0.1 mg/kg/day) and the studies repeated. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS1333 GDS1334

Platforms:

GPL97 GPL96

12 Samples

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Analysis of gastrocnemius muscle biopsy specimens from Duchenne muscular dystrophy (DMD) patients before and after 3 months of treatment with 0.1mg/kg/day oxandrolone, a synthetic anabolic steroid. Results provide insight into mechanisms underlying the beneficial effect of oxandrolone in DMD.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 individual sets

Platform:

GPL97

Series:

GSE1764

6 Samples

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Analysis of gastrocnemius muscle biopsy specimens from Duchenne muscular dystrophy (DMD) patients before and after 3 months of treatment with 0.1mg/kg/day oxandrolone, a synthetic anabolic steroid. Results provide insight into mechanisms underlying the beneficial effect of oxandrolone in DMD.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 individual sets

Platform:

GPL96

Series:

GSE1764

6 Samples

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(Submitter supplied) Using Affymetrix GeneChips, we analyzed expression profiles of SP cells from EOM and TA. 348 differentially expressed transcripts defined the EOM-SP transcriptome: 229 upregulated in EOM-SP and 119 in TA-SP. Keywords: Expression Profiling

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

12 Samples

Download data: CEL

(Submitter supplied) The extraocular muscles (EOMs) are a unique group of muscles that are anatomically and physiologically distinct from other skeletal muscles. Previously, we and others have shown that EOMs have a unique transcriptome and proteome. Here, we investigated the expression pattern of microRNAs (miRNAs) in EOM, as they may play a role in generating the unique EOM allotype. We screened LC Sciences miRNA microarrays covering the sequences of miRBase 10.0 to define the microRNAome of normal mouse EOM and tibialis anterior (TA) limb muscle. more...

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL8605

8 Samples

Download data: TXT

(Submitter supplied) Primairy human myoblast cell cultures Healthy DMD Keywords: time-course

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2097

42 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL9454 GPL570

65 Samples

Download data: CEL

(Submitter supplied) Evaluation of extraocular muscle (EOM) critical period by expression profiling in dark reared rat. Data form part of publication: Investigative Ophthalmology and Visual Sciences 44: 3842-3855, 2003. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by SAGE

Platform:

GPL23

2 Samples

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(Submitter supplied) vastus lateralis biopsies were obtained from healthy subjects, either young adults (20-29 yr old) or older (65-75 yr old) Keywords = muscle Keywords = aging Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS287 GDS288

Platforms:

GPL96 GPL97

30 Samples

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Comparison of gene expression in vastus lateralis skeletal muscle biopsies in healthy young (21-27 year old) and older (67-75 year old) men.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL97

Series:

GSE362

15 Samples

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Comparison of gene expression in vastus lateralis skeletal muscle biopsies in healthy young (21-27 year old) and older (67-75 year old) men

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL96

Series:

GSE362

15 Samples

Download data

(Submitter supplied) Human strabismic extraocular muscles (EOMs) differ from normal EOMs in structural and functional properties, but the gene expression profile of these two types of human EOM has not been examined. Differences in gene expression may inform about causes and effects of the strabismic condition in humans. Our samples are from human strabismic patients undergoing corrective surgery, and from human organ donors with no history of EOM disease. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

8 Samples

Download data: CEL