GEO DataSets

(Submitter supplied) Hindlimb suspension for 7 days, subsequent reloading for 7 days Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1097

5 Samples

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(Submitter supplied) Analysis of effect of hindlimb suspension and reloading on C57Bl/6 mouse soleus muscle. Experimental groups examined: -Control mice, 14 days -Hindlimb suspension for 7 days -Hindlimb suspension for 7 days, and subsequent reloading for 1 day -Hindlimb suspension for 7 days, and subsequent reloading for 7 days Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1097

23 Samples

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(Submitter supplied) Hindlimb suspended for 7 days, subsequent reloading for 1 day Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1097

6 Samples

Download data

(Submitter supplied) Hindlimb suspended for 7 days Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1097

6 Samples

Download data

(Submitter supplied) Control mice, 14 days Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1097

6 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL153

23 Samples

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(Submitter supplied) 14 days hindlimb suspended, 5 days reloaded m. soleus RNA was isolated from cryosections using RNeasy kit (Qiagen). 5 microgram total RNA was subjected to microarray analysis. Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL153

5 Samples

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(Submitter supplied) Examination of effect of mechanical loading induced by hindlimb suspension, and subsequent reloading, in soleus muscle in 14 day old female pathogen–free Wistar rats. Keywords = skeletal muscle Keywords = atrophy Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL153

18 Samples

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(Submitter supplied) This experiment was conducted to identify target genes of the peroxisome proliferator-activated receptor alpha (PPARa) in skeletal muscle of transgenic mice that overexpressed PPARa. The following abstract from the published manuscript describes the major findings of this work. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2289

Platform:

GPL339

4 Samples

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Analysis of skeletal muscles of transgenics (trs) overexpressing PPARalpha. Trs overexpressing PPARalpha develop glucose intolerance despite protection from diet-induced obesity. Results provide insight into the role of PPARalpha in the development of insulin-resistant diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE5777

4 Samples

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(Submitter supplied) The right legs of 8 Brown-Norway male rats were denervated by a high sciatic nerve section in the hip region of the hind limb.Two months after denervation (6 months of age), extensor digitorum longus (EDL) muscles were removed from the operated legs. The EDL muscles from 8 age-matched non-operated rats served as innervated controls. Total RNA was isolated, labeled cDNA was prepared and hybridized to the Rat Atlas 1.2 Array II membranes (Clontech Laboratories, Palo Alto, CA). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL154

16 Samples

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(Submitter supplied) Spaceflight results in a number of adaptations to skeletal muscle, including atrophy and shifts towards faster muscle fiber types. To identify changes in gene expression that may underlie these adaptations, microarray expression analysis was performed on gastrocnemius from mice flown on the STS-108 shuttle flight (11 days, 19 hours) versus mice maintained on earth for the same period. Additionally, to identify changes that were due to unloading and reloading, microarray analyses were conducted on calf muscle from ground-based mice subjected to hindlimb suspension (12 days) and mice subjected to hindlimb suspension plus a brief period of reloading (3.5 hours) to simulate the time between landing and sacrifice of the spaceflight mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

23 Samples

Download data: CEL

(Submitter supplied) Conserved and muscle group-specific gene expression patterns shape postnatal development of the novel extraocular muscle phenotype. Comparison of postnatal development of extraocular and hindlimb muscle between birth and P45. Keywords: parallel sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS621

Platform:

GPL85

36 Samples

Download data: CEL

Analysis of hindlimb and extraocular muscle (EOM) between birth and postnatal day 45. Dissecting allotype-specific regulatory mechanisms may help explain differential muscle group sensitivity to a variety of metabolic and neuromuscular diseases.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 6 age, 2 tissue sets

Platform:

GPL85

Series:

GSE903

36 Samples

Download data: CEL

(Submitter supplied) Three male 8-week-old Wistar rats were used. The peroneal nerve of the animals was transected and sutured to the biceps femoris muscle. Four weeks later, the proximal stump was sutured to the distal stump. The animals survived for 8 weeks. All experiments were performed under Ketanest (ketamine hydrochloride, Essex Pharma GmbH, Munich, Germany; 100 mg/kg) and Rompun (xylazine hydrochloride, Bayer, Leverkusen, Germany; 10 mg/kg) anesthesia. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2243

Platform:

GPL341

6 Samples

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Analysis of reinnervated tibialis anterior muscles that were previously denervated for 4 weeks. Denervation-induced myofiber atrophy can be reversed by reinnervation. Results provide insight into the molecular mechanisms contributing to myofiber growth after reinnervation.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL341

Series:

GSE2566

6 Samples

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(Submitter supplied) Adult rat global and orbital layers of rectal extraocular muscles microdissected using Arcturus Pixcell II LCM are gene profiled here using affymetrix rat RAE230A gene chip. www.med.upenn.edu/cellbio/faculty/rubinstein/ www.uphs.upenn.edu/pmi/members/khurana/lab%20page.htm Keywords: ordered

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS851

Platform:

GPL341

8 Samples

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Expression profiling of microdissected global and orbital layers of the rectus extraocular muscle (EOM) from 2 adult Sprague-Dawleys. By identifying molecular differences between the 2 layers, results provide insight into the possible specialized function of each muscle layer.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL341

Series:

GSE1374

8 Samples

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(Submitter supplied) Comparison of gene expression in young soleus muscle (3-4 months) with old soleus muscle (30-31 months). Keywords: parallel sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL85 GPL86 GPL87

296 Samples

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(Submitter supplied) Exposure to 20.9% or 10.5% O2 for 24 hours of wildtype control mice, mice reloaded after hindlimb suspension and control HIF-1 alpha heterozygote mice, respectively. Keywords: ordered

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1097

36 Samples

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