GEO DataSets

(Submitter supplied) Summary: To identify distinct temporal patterns of mRNA expression in the kidney of rats following a bolus dose of the corticosteroid methylprednisolone. Hypothesis: That prednisone pharmacodynamics can be derived from expression profiling data. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS964 GDS965

Platforms:

GPL341 GPL85

63 Samples

Download data: CEL

Expression profiling of kidneys from animals treated with methylprednisolone. Kidneys examined at various time points up to 6 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 3 time sets

Platform:

GPL85

Series:

GSE1721

10 Samples

Download data: CEL

Expression profiling of kidneys from animals treated with methylprednisolone. Kidneys examined at various time points up to 72 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 17 time sets

Platform:

GPL341

Series:

GSE1721

53 Samples

Download data: CEL

(Submitter supplied) Synthetic glucocorticoids are used therapeutically for a variety of conditions. Both the efficacy and toxicity of corticosteroids arise from their pharmacologically exaggerated effects on target and non-target tissues. For example, beneficial effects deriving from inhibition of the immune system are accompanied by toxic side effects that include hyperglycemia, dyslipidaemia, muscle wasting, fatty liver, and an increased risk of atherosclerosis. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2688

Platform:

GPL341

44 Samples

Download data: CEL

Analysis of skeletal muscles of adrenalectomized animals given methylprednisolone (MPL) at a constant rate of infusion for up to 7 days. Results compared to a time series experiment using a single dose of MPL. Results provide insight into the identity of genes regulated by MPL in both regimens.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 11 time sets

Platform:

GPL341

Series:

GSE5101

44 Samples

Download data: CEL

(Submitter supplied) The aim of this project is to identify distinct temporal patterns of RNA expression in the skeletal muscle of rats following a bolus dose of the corticosteroid methylprednisolone. 51 RG_U34A chips were used over 17 time points. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS256

Platform:

GPL85

51 Samples

Download data: CEL

Temporal analysis of skeletal muscle response to corticosteroid methylprednisolone. Wistar rats injected with methylprednisolone and skeletal muscle analyzed at various time points up to 72 hours.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 17 time sets

Platform:

GPL85

Series:

GSE490

51 Samples

Download data: CEL

(Submitter supplied) Summary: The liver is the major site of gluconeogenesis, fat processing and distribution, as well as drug and xenobiotic metabolism. Altered gene expression in the liver is centrally invovled in both the immuosuppressive and the energetic actions of corticosteroids. Hypothesis: That pharmacodynamics can be derived from expression profiling data. Specific Aim: The aim of this project is to identify distinct temporal patters of RNA expression in the liver of rats following a bolus dose of the corticosteroid methylprednisolone. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS253 GDS972

Platforms:

GPL341 GPL85

91 Samples

Download data: CEL

Expression profiling of liver from animals treated with methylprednisolone. Liver examined at various time points up to 168 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 11 time sets

Platform:

GPL341

Series:

GSE487

44 Samples

Download data: CEL

Expression profiling of liver from animals treated with methylprednisolone. Liver examined at various time points up to 72 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 17 time sets

Platform:

GPL85

Series:

GSE487

46 Samples

Download data: CEL

(Submitter supplied) In intact animals, time of drug administration may be an important factor influencing drug response. Our general goal seeks to incorporate circadian time into the study of corticosteroid regulated gene expression. This study is designed to examine fluctuations in gene expression in skeletal muscle within the 24 hour circadian cycle in normal animals. Circadian time is relevant to designing optimal corticosteroid dosing regimens. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3083

Platform:

GPL341

54 Samples

Download data: CEL

Analysis of gastrocnemius muscles of Wistar animals during a 24-hour period, from zeitgeber time (ZT) 0.25 to ZT 23.75. Results provide insight into baseline patterns of gene expression in normal skeletal muscle within the 24 hour circadian cycle.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 18 time sets

Platform:

GPL341

Series:

GSE8989

54 Samples

Download data: CEL

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) RNA-Seq has been increasingly used for the quantification and characterization of transcriptomes. The ongoing development of the technology promises the more accurate measurement of gene expression. However, its benefits over widely accepted microarray technologies have not been adequately assessed, especially in toxicogenomics studies. The goal of this study is to enhance the scientific community's understanding of the advantages and challenges of RNA-Seq in the quantification of gene expression by comparing analysis results from RNA-Seq and microarray data on a toxicogenomics study. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL10287

8 Samples

Download data: TXT

(Submitter supplied) A series of dual-channel gene expression profiles obtained using MWG Rat 5K microarrays (~5535 unique rat genes) and MWG Rat Liver microarrays (~1353 unique rat genes with 999 of these genes also represented on the Rat 5K microarray) was used to examine the sex-dependent and GH-dependent differences in gene expression in adult rat liver. This series is comprised of 8 randomly chosen pairings of independent male and female rat liver cDNA samples and 8 randomly chosen pairings of independent male and continuous GH-treated male rat liver cDNA samples, totaling 16 samples. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS862 GDS863

Platforms:

GPL529 GPL500

16 Samples

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Investigation of regulatory role of growth hormone (GH) in sexually dimorphic gene expression. Liver tissue examined from adult male and female rats untreated or treated with GH by 7 day continuous infusion.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 2 other sets

Platform:

GPL529

Series:

GSE1146

8 Samples

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Investigation of regulatory role of growth hormone (GH) in sexually dimorphic gene expression. Liver tissue from adult male and female rats untreated or treated with GH by 7 day continuous infusion examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 2 other sets

Platform:

GPL500

Series:

GSE1146

8 Samples

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(Submitter supplied) Although studies have established that exogenous growth hormone (GH) treatment stimulates growth in fish, its effects on target tissue gene expression are not well characterized. We assessed the effects Posilac® (Monsanto Co., St. Louis, MO), a recombinant bovine somatotropin, on tissue transcript levels. Transcript abundance was measure in liver and muscle using the GRASP 16 K cDNA microarray. A selection of the genes identified as altered with the microarray, and also transcripts for insulin-like growth factors, growth hormone receptors (GHR) and myostatins were measured by realtime PCR in the liver, muscle, brain, kidney, intestine, stomach, gill and heart. more...

Organism:

Oncorhynchus mykiss; Salmo salar

Type:

Expression profiling by array

Platform:

GPL3976

16 Samples

Download data: TXT

(Submitter supplied) To better understand what genes are regulated by PPAR gamma, an experimental dataset was generated by microarray analysis, in duplicate, of pooled aortic mRNA isolated from adult male mice (C57BL/6J strain) treated for 21 days with a PPAR gamma agonist (rosiglitazone) or vehicle. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS859

Platform:

GPL81

4 Samples

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