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Links from GEO DataSets

Items: 17

1.

Dexamethasone treatment of gut cells

(Submitter supplied) Reference pool RNA versus RNA from dexamethasone treated gut cells. Keywords: other
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1465
4 Samples
Download data
Series
Accession:
GSE1826
ID:
200001826
2.

Glucocorticoid Induced Changes in Gene Expression in Human Lens Epithelial Cells

(Submitter supplied) Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the short term biological effect of glucocorticoid action in lens epithelial cells is not known. This study seeks to examine glucocorticoid induced changes in global gene expression in LECs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1353
Platform:
GPL96
12 Samples
Download data
Series
Accession:
GSE3040
ID:
200003040
3.
Full record GDS1353

Glucocorticoid effect on lens epithelial cells: time course

Analysis of cultured immortalized lens epithelial cells (LEC) 4 and 16 hours after treatment with 1 uM dexamethasone, a glucocorticoid steroid hormone. Long-term glucocorticoid use can induce cataract formation. Results identify glucocorticoid targets and short-term effects of glucocorticoid on LECs
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL96
Series:
GSE3040
12 Samples
Download data
DataSet
Accession:
GDS1353
ID:
1353
4.

Gene regulation in the hyperoxia mouse retina

(Submitter supplied) PURPOSE: Hyperoxia is toxic to photoreceptors, and this toxicity may be important in the progress of retinal dystrophies. This microarray study examines gene expression induced in the C57BL/6J mouse retina by hyperoxia over the 14-day period during which photoreceptors first resist, then succumb to, hyperoxia. METHODS: Young adult C57BL/6J mice were exposed to hyperoxia (75% oxygen) for up to 14 days. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL, CHP
Series
Accession:
GSE23437
ID:
200023437
5.

Microarray Analysis of Retinal Gene Expression in the DBA/2J Model of Glaucoma

(Submitter supplied) Purpose: The DBA/2J mouse is a model for secondary angle-closure glaucoma due to iris atrophy and pigment dispersion, which ultimately leads to increased intraocular pressure (IOP). We sought to correlate changes in retinal gene expression with glaucoma-like pathology by performing microarray analysis of retinal RNA from DBA/2J mice at 3 months before disease onset, and at 8 months, after IOP elevation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1728
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE3554
ID:
200003554
6.
Full record GDS1728

DBA/2J model of glaucoma: retina

Analysis of retinas from strain DBA/2J with elevated intraocular pressure (IOP). A model for glaucoma, DBA/2J has mutations that lead to iris atrophy and pigment dispersion. These conditions result in increased IOP. Results provide insight into the molecular changes associated with IOP elevation.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 disease state sets
Platform:
GPL1261
Series:
GSE3554
6 Samples
Download data: CEL
DataSet
Accession:
GDS1728
ID:
1728
7.

Comparison of gene expression profile of human trabecular meshwork cells induced by triamcinolone with dexamethasone

(Submitter supplied) PURPOSE. Triamcinolone acetonide (TA) and dexamethasone (DEX) are corticosteroids commonly used for ocular inflammation but both can cause ocular hypertension. We investigated the differential gene expression profile of human trabecular meshwork (TM) cells in response to treatment by TA compared to that by DEX. METHODS. Total RNA was extracted from cultured human TM cells treated with TA or DEX and used for microarray gene expression analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4564
9 Samples
Download data
Series
Accession:
GSE6298
ID:
200006298
8.

The Influence of Interferon Gamma on Gene Expression in Normal Human Bronchial Epithelial Cells

(Submitter supplied) RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone. Keywords = interferon gamma Keywords = dexamethasone Keywords = human bronchial epithelial cells Keywords: dose response
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1256
Platform:
GPL8300
36 Samples
Download data
Series
Accession:
GSE1815
ID:
200001815
9.
Full record GDS1256

IFN-gamma inflammatory effect on bronchial epithelial cells modulated by dexamethasone: time course

Analysis of bronchial epithelial cells treated with interferon (IFN) gamma, or dexamethasone (dex), or both. IFN-gamma plays a role in lung inflammatory responses and corticosteroids such as dex are used as treatments for inflammation. Cells examined 8 or 24 hours after treatment.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 agent, 2 time sets
Platform:
GPL8300
Series:
GSE1815
36 Samples
Download data
DataSet
Accession:
GDS1256
ID:
1256
10.

Rat duodenum during immobilization

(Submitter supplied) In the present study, we examined duodenal gene expression in rats subjected to immobilization, to elucidate the mechanism of the stress response in the duodenum. Keywords: stress response
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL85
2 Samples
Download data
Series
Accession:
GSE4426
ID:
200004426
11.

Profiling of gender-regulated gene transcripts in the filarial nematode Brugia malayi by oligonucleotide array analysis

(Submitter supplied) Microarray technology permits high throughput comparisons of gene expression in different parasite stages or sexes. We now report the first use of this technology for analysis of gene expression in filarial worms. The slide array (comprised of 65 mer oligos representing 3569 EST clusters) was spotted with sequences selected from the extensive Brugia malayi EST database (http://nema.cap.ed.ac.uk/nematodeESTs/nembase.html#Annotation). more...
Organism:
Brugia malayi
Type:
Expression profiling by array
Platform:
GPL1483
8 Samples
Download data
Series
Accession:
GSE2038
ID:
200002038
12.

Mouse Retina P7 Rs1h KO versus Control

(Submitter supplied) Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Keywords: Genetic modification
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2636
Platform:
GPL339
6 Samples
Download data
Series
Accession:
GSE5581
ID:
200005581
13.
Full record GDS2636

Retinoschisis model

Analysis of retinas from postnatal day 7 mutants lacking retinoschisin (RS1h), an animal model for retinoschisis (RS). RS is a recessive retinal dystrophy accompanied by macular disease often resulting in early-onset vision loss. Results provide insight into the pathogenesis of RS.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE5581
6 Samples
Download data
DataSet
Accession:
GDS2636
ID:
2636
14.

gene expression profiling of mouse model of Helicobacter-induced gastric cancer

(Submitter supplied) We have previously reported human gastrin overexpressing transgenic mice (=INS-GAS mice) and Helicobacter felis (=H.felis) infection synergistically accelerated gastric cancer in mice stomachs. (Wang et al 2000) Using this mouse model, we employed microarray analysis of gene expression profiling to identify gastric cancer-specific genes. Keywords: disease state analysis
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2103
Platform:
GPL81
5 Samples
Download data
Series
Accession:
GSE4651
ID:
200004651
15.
Full record GDS2103

Helicobacter-induced gastric cancer model

Analysis of cancerous stomach tissues of human gastrin overexpressing transgenic animals 6 months following infection with Helicobacter felis. Gastrin overexpression and H. felis infection synergistically accelerate gastric cancer in this model. Results identify gastric cancer-specific genes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 infection sets
Platform:
GPL81
Series:
GSE4651
5 Samples
Download data
DataSet
Accession:
GDS2103
ID:
2103
16.

Gene expression profiling in small intestine of mice administered lactoperoxidase

(Submitter supplied) Lactoperoxidase (LPO) is a component of milk and other external secretions. Recently, we found antiinflammatory effect of orally administered LPO in mouse model of influenza virus-induced pneumonia. In order to study influence of bovine LPO on the digestive tract as its possible target organ, we performed comprehensive gene expression analysis of the mouse small intestine using GeneChip microarray to compare the effect of LPO with that of water or bovine serum albumin (BSA). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2288
Platform:
GPL1261
9 Samples
Download data
Series
Accession:
GSE5562
ID:
200005562
17.
Full record GDS2288

Lactoperoxidase effect on the small intestine

Analysis of small intestines of animals 3 hours after ingesting bovine lactoperoxidase (LPO). LPO is a component of milk and exhibits antiviral activities as well as immuno-modulatory effects. Results provide insight into the effect of LPO on the digestive tract.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 agent sets
Platform:
GPL1261
Series:
GSE5562
9 Samples
Download data
DataSet
Accession:
GDS2288
ID:
2288
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