Similar studies for GEO DataSets (Select 200002060) - GEO DataSets

Select item 2000020601.

Characterize CREB target genes in different tissue types

(Submitter supplied) The CREB family of transcription factors stimulates cellular gene expression following phosphorylation at a conserved serine (Ser133 in CREB1) in response to cAMP and other extracellular signals. In order to characterize CREB target genes in various tissues, we give a cAMP agonist, forskolin (FSK), to cell lines or primary cultures and monitor the gene expression. To eliminate CREB-independent effects of FSK on cellular gene expression, we employed a dominant negative form of CREB called A-CREB, which dimerizes selectively with and blocks the DNA binding activity of CREB but not other bZIP family members. more...

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array

4 related Platforms
27 Samples

Download data: CEL, EXP

Series

Accession:: GSE2060

ID:: 200002060

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000838912.

Tunable regulation of CREB DNA binding activity couples genotoxic stress response and metabolism

(Submitter supplied) In this study we show that, in embryonic fibroblasts from mice on a high fat diet and treated with Forskolin, ionizing radiation exposure or both, phosphorylation of CREB-binding protein (CREB) by ATM (ataxia-telangiectasia-mutated) and casein kinases 1 and 2 (CK1 and CK2) on a cluster of five phosphorylation sites (the ATM/CK cluster) within the unstructured kinase-inducible domain (KID) provides an additional level of regulation through dynamic modulation of CREB DNA binding activity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
48 Samples

Download data: TXT

Series

Accession:: GSE83891

ID:: 200083891

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000183473.

CREB ChIP-chip and HaloCHIP-chip experiments

(Submitter supplied) Regulation of gene expression is essential for normal development and cellular growth. Transcriptional events are tightly controlled both spatially and temporally by specific DNA-protein interactions. In this study we finely map the genome-wide targets of the CREB protein across all known and predicted human promoters, and characterize the functional consequences of a subset of these binding events using high-throughput reporter assays. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL9325
9 Samples

Download data: TXT

Series

Accession:: GSE18347

ID:: 200018347

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000457334.

Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL11002 GPL10333
16 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE45733

ID:: 200045733

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000457315.

Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver [array]

(Submitter supplied) Metabolic homeostasis in mammals critically depends on the regulation of fasting-induced genes by CREB in the liver. Previous genome-wide analysis has shown that only a small percentage of CREB target genes are induced in response to fasting-associated signaling pathways. The precise molecular mechanisms by which CREB specifically targets these genes in response to alternating hormonal cues remain to be elucidated. more...