Similar studies for GEO DataSets (Select 200002377) - GEO DataSets

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Items: 3

Select item 2000023771.

Induction of Pathogenic Sets of Genes in Macrophages and Neurons in NeuroAIDS

(Submitter supplied) The etiology of the central nervous system (CNS) alterations after human immunodeficiency virus (HIV) infection, such as dementia and encephalitis, remains unknown. We have used microarray analysis in a monkey model of neuroAIDS to identify 98 genes, many previously unrecognized in lentiviral CNS pathogenesis, whose expression is significantly up-regulated in the frontal lobe of simian immunodeficiency virus-infected brains. more...

Organism:: Macaca mulatta; Homo sapiens

Type:: Expression profiling by array

Platform:: GPL8300
48 Samples

Download data: CEL, EXP

Series

Accession:: GSE2377

ID:: 200002377

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000023932.

Expression patterns throughout disease progression and impact on neuroAIDS.

(Submitter supplied) The virus/host interactions during the acute phase of human immunodeficiency virus (HIV) infection help determine the course of disease. During this time period, virus enters the brain. Here, we report clusters of genes whose transcripts are significantly upregulated in the frontal lobe of the brain during acute simian immunodeficiency virus (SIV) infection of rhesus monkeys. Many of these genes are involved in interferon (IFN) and/or interleukin (IL)-6 pathways. more...

Organism:: Macaca mulatta; Homo sapiens

Type:: Expression profiling by array

Platform:: GPL8300
34 Samples

Download data: CEL, EXP

Series

Accession:: GSE2393

ID:: 200002393

Select item 2001603843.

Methamphetamine increases the proportion of SIV-infected microglia/macrophages, alters metabolic pathways, and elevates cell death pathways: a single-cell analysis

(Submitter supplied) Both drugs abuse and HIV infection continue to affect many indiviiduals. Both have untoward effects on the brain, and the two conditions often co-exist. In the brain, macrophages and microglia are infectable by HIV, and these cells are also targets for the effects of drugs of abuse such as the psychostimulant methamphetamine. In order to determine the interaction of HIV and methamphetamine we isolated microglia and macrophages from the brains of SIV-infected rhesus monkeys treated with methamphetamine and from SIV-infected monkeys who did not receive methamphetamine. more...