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Links from GEO DataSets

Items: 9

1.

Chronic contusion spinal cord injury in rats

(Submitter supplied) Excerpt from a larger study which characterized the transcriptional effects of a spinal cord contusion injury in rats. This is the data from the almost chronic contusion state (35 days) at the injury site (Thoracic 8) - where we saw significant changes in several areas, including cholesterol metabolism genes. Other spinal cord areas (rostral, caudal) and time-points (3 hours, 24 hours, 7 days and 35 days) were analyzed as well and are discussed in our paper and at www.crpf.org/microarray. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS1238
Platform:
GPL85
6 Samples
Download data
Series
Accession:
GSE2599
ID:
200002599
2.
Full record GDS1238

Spinal cord contusion

Expression profiling of contused spinal cords of Fischer animals. Spinal cords examined 35 days following contusion at the thoracic 8 segment. Results identify potential targets for therapeutic intervention following spinal cord injury.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 shock sets
Platform:
GPL85
Series:
GSE2599
6 Samples
Download data
DataSet
Accession:
GDS1238
ID:
1238
3.

Burn20

(Submitter supplied) Type of experiment: Comparison of liver samples between sham (control) and 20% TBSA (total burn surface area) burn rats collected at 1h, 4h, 8h, and 24h. Experimental factors: Burn injury and time Experiment design: All experimental liver samples collected after 1h, 4h, 8h, and 24h after burn injury were compared to a common reference (sham control treated as 0h time point) Bio source: Sprague-Drawley male rats weighing 150-200 g supplied through Charles river laboratories, MA (www.criver.com) Bio material manipulations: Rats (n=3 for each scald-burn and sham-burn time point) were individually housed in a temperature-controlled (25oC) and light-controlled room (12h light-dark cycle) and allowed to adjust to their new surroundings for at least 5 days prior to the experiment. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS599
Platform:
GPL85
10 Samples
Download data
Series
Accession:
GSE802
ID:
200000802
4.
Full record GDS599

Burn injury: liver metabolic and inflammatory response

Temporal analysis of metabolic and inflammatory response to burn injury. Livers from male Sprague-Dawleys examined at 1, 4, 8, and 24 hours following 20% total burn surface area scald-burn injury.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 5 time sets
Platform:
GPL85
Series:
GSE802
10 Samples
Download data
5.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3643
Platform:
GPL1355
24 Samples
Download data: CEL
Series
Accession:
GSE10748
ID:
200010748
6.
Full record GDS3643

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 6 dose sets
Platform:
GPL1355
Series:
GSE10748
24 Samples
Download data: CEL
DataSet
Accession:
GDS3643
ID:
3643
7.

Urinary bladder post-spinal cord injury: time-points

(Submitter supplied) Previously, we demonstrated using a rat model of spinal cord injury (SCI) that bladder wall tissue compliance significantly increased within the first 2 weeks following injury. In order to explore the potential molecular-level mechanisms of this event, the present study quantified molecules pertinent to bladder tissue remodeling and changes in mechanical properties. An initial gene array analysis followed by real-time qPCR revealed that the message levels for tropoelastin and lysyl oxidase were as high as 8-fold in SCI rats compared to normal. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3507
Platform:
GPL85
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE14096
ID:
200014096
8.
Full record GDS3507

Spinal cord injury effect on the urinary bladder: time course

Analysis of bladders from Sprague-Dawley females for up to 25 days following spinal cord injury (SCI). Bladder wall tissue compliance increases within 2 weeks after SCI in this animal model. Results provide insight into the molecular basis of the changes that the bladder undergoes after SCI.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 disease state, 4 time sets
Platform:
GPL85
Series:
GSE14096
4 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS3507
ID:
3507
9.

LPS Blood Time course

(Submitter supplied) cDNA microarray study of gene expression changes in whole blood from LPS treated rats, 2 and 6 hours after I.P. injection of 5 mg/kg Keywords: time-course
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1344
12 Samples
Download data: TIFF
Series
Accession:
GSE1658
ID:
200001658
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