GEO DataSets

(Submitter supplied) right lung gene expression of C57BL/6J, A/J and C3H/HeJ mice following bleomcyin exposure Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1492

Platform:

GPL339

21 Samples

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Comparison of lungs from C57BL/6J and C3H/HeJ strains, 3 and 6 weeks after treatment with 80, 100, or 125 units of bleomycin/kg. C57BL/6Js are susceptible to bleomycin-induced pulmonary fibrosis, while C3H/HeJs are resistant. Results identify candidate genes underlying fibrosis susceptibility.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 4 dose, 2 gender, 2 other, 3 strain, 3 time sets

Platform:

GPL339

Series:

GSE2640

21 Samples

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(Submitter supplied) Gene expression profiling with microarrays was used to identify genes differentially expressed in the lungs of B6 and BALB CF mice compared to non-CF littermates Keywords: disease state analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1941

Platform:

GPL1261

23 Samples

Download data: CEL

Analysis of lungs of C57BL/6J (B6) or BALB/c (BALB) animals deficient for cystic fibrosis transmembrane conductance regulator (CFTR). B6 background animals have a higher propensity to develop CF lung disease. Results suggest the variable severity of CF is controlled by multiple genetic factors.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 gender, 2 genotype/variation, 2 strain sets

Platform:

GPL1261

Series:

GSE3100

23 Samples

Download data: CEL

(Submitter supplied) Examination of molecular basis of malaria resistance. Spleens from malaria resistant AcB55 and AcB61strains compared with A/J mice. Animals were sacrificed and spleens were rapidly frozen in liquid nitrogen, and subsequently stored at 80oC. Tissues were mechanically homogenized with a polytron and total cellular RNA was extracted using a commercially available reagent (TMTRIzol; Invitrogen). The poly-(A)+ fraction of the RNA was isolated by chromatography with oligo d(T) cellulose beads. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS471

Platform:

GPL519

14 Samples

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Examination of molecular basis of malaria resistance. Spleens from malaria resistant recombinant congenic strains AcB55 and AcB61 compared with malaria susceptible A/J mice.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 2 strain sets

Platform:

GPL519

Series:

GSE709

14 Samples

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(Submitter supplied) Expression profiling of liver tissue from 111 F2 female mice resulting from a cross between C57BL/6J and DBA/2J inbred mouse strains. Mice were feed a chow diet for 12 months followed by 4 months on an atherogenic high-fat, high-cholesterol diet. Parental and F2 mice were killed at 16 months of age. The livers were removed immediately and flash frozen for expression profiling. See Schadt, et al., Nature , Vol 422(6929):297-302 for details. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1717

107 Samples

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(Submitter supplied) Expression profiles in aortas isolated from mouse strains C3H.2/HeJ and C57.2Bl/6. Mice were were either on a high fat diet or normal diet for 0, 4, 10, 24, or 40 weeks. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS735

Platform:

GPL891

54 Samples

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Comparison of gene expression in aortas of C57BL/6 and C3H/HeJ fed identical high fat diets at 0, 4, 8, 24, and 40 weeks. C57BL/6 has a greater tendency than C3H/HeJ to develop atherosclerotic aortic lesions when both fed identical high fat diets.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 2 growth protocol, 2 strain, 5 time sets

Platform:

GPL891

Series:

GSE1560

54 Samples

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(Submitter supplied) The pathogenesis of viral myocarditis is a multifactorial process involving host genetics, viral genetics and the environment in which they interact. Here, we used a model of infection with Coxsackievirus B3 to characterize the contribution of host genetics to viral myocarditis. We determined heart CVB3 load in mice from a classical intercross between progenitors A/J (H2a) and B10.A-H2a (B10.A) of different genetic backgrounds but with a common H2 haplotype. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

24 Samples

Download data: TXT

(Submitter supplied) Several studies have shown that bone mineral density (BMD), a clinically measurable predictor of osteoporotic fracture, is the sum of genetic and environmental influences. In addition, serum IGF-1 levels have been correlated to both BMD and fracture risk. We previously identified a Quantitative Trait Locus (QTL) for Bone Mineral Density (BMD) on mouse Chromosome (Chr) 6 that overlaps a QTL for serum IGF-1. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2442

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of livers of animals with decreased serum insulin-like growth factor-I (IGF-I) levels. The liver is the major source of serum IGF-I. The level of serum IGF-I is correlated to bone mineral density (BMD) and fracture risk. Results provide insight into the relationship between IGF-I and BMD.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 other, 2 strain sets

Platform:

GPL1261

Series:

GSE5959

6 Samples

Download data: CEL

(Submitter supplied) We tested the hypothesis that a set of differentially expressed genes could be used to predict cardiovascular phenotype in mice after prolonged catecholamine stress. Keywords: Treatment

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3684

Platform:

GPL1261

86 Samples

Download data: CEL

Analysis of hearts of various wild type and beta2 adrenergic receptor (B2KO) deficient animals subjected to catecholamine (CA) stress by beta receptor agonist isoproterenol treatment. B2KO mutants and FVB wild type animals develop left ventricle systolic dysfunction in response to CA stress.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 4 strain sets

Platform:

GPL1261

Series:

GSE12413

86 Samples

Download data: CEL

(Submitter supplied) Serial analysis of gene expression (SAGE) was used to identify and quantify all expressed cerebellar genes in the adult (P92; GSM17430) and aged (P810; GSM17226) C57BL/6J mouse cerebellum. A "closest-neighbor" algorithm was used to differentiate low abundance tags from possible sequencing errors in both libraries. Unique tags were categorized into four groups: (1) novel genes; (2) ESTs; (3) RIKEN, KIA, and hypothetical genes; and (4) known genes. more...

Organism:

Mus musculus

Type:

Expression profiling by SAGE

Platform:

GPL11

5 Samples

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(Submitter supplied) Mouse inbred strains differ in many aspects of their phenotypes, and it is known that gene expression does so too. This gives us an opportunity to isolate the genetic aspect of variation in expression and compare it to other phenotypic variables. We have investigated these issues using an eight-strain expression profile comparison with four replicates per strain on Affymetrix MGU74av2 GeneChips focusing on one well-defined brain tissue (the hippocampus). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2226

Platform:

GPL81

32 Samples

Download data: CEL

Analysis of hippocampi from 8 inbred strains. The hippocampus is a key area of the brain involved in behaviors such as learning, memory, anxiety, and aggression. Results provide insight into strain-specific gene expression differences and their relationship to phenotypic variables such as behavior.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 8 strain sets

Platform:

GPL81

Series:

GSE5429

32 Samples

Download data: CEL

(Submitter supplied) Abstract: Interleukin-10-deficient (Il10-/-) mice serve as a model for inflammatory bowel disease (IBD). The severity of colitis strongly depends on the inbred strain carrying the disrupted Il10 gene: C3H/HeJBir (C3) confers disease susceptibility, whereas C57BL/6J (B6) confers resistance. Genome-wide scans with microsatellite markers on segregrating backcross and F2 populations resulted in the detection of ten colitogenic quantitative trait loci (QTL). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1871

Platform:

GPL81

8 Samples

Download data: CEL, EXP

Analysis of colons of C3H/HeJBir and C57BL/6J strains following interleukin-10 (IL-10) gene disruption. IL-10 disruption leads to colitis in C3H/HeJBir strain but not in C57BL/6J. Results used to reduce the number of candidate genes associated with colitogenic quantitative trait loci regions.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 strain sets

Platform:

GPL81

Series:

GSE2172

8 Samples

Download data: CEL, EXP

(Submitter supplied) Human cardiomyopathies often lead to heart failure, a major cause of morbidity and mortality in industrialized nations. Described here is a phenotypic characterization of cardiac function and genome-wide expression from C3H/HeJ, C57BL/6J, and B6C3F1/J male mice. Histopathologic analysis identified a low-grade background cardiomyopathy (murine progressive cardiomyopathy) in eight of nine male C3H/HeJ mice (age nine to ten weeks), but not in male C57BL/6J and in only of ten male B6C3F1/J mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

15 Samples

Download data: CEL