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Links from GEO DataSets

Items: 20

1.

Comparative SAGE Analysis of the Response to Hypoxia in Human Pulmonary and Aortic Endothelial Cells

(Submitter supplied) Cultures of human aortic (HAEC) and pulmonary artery endothelial cells (HPAEC) were exposured to short-term chronic hypoxia (1% O2) for either 0h, 8h or 24h Keywords: Time course, cell-type comparison
Organism:
Homo sapiens
Type:
Expression profiling by SAGE
Platform:
GPL4
6 Samples
Download data
Series
Accession:
GSE2838
ID:
200002838
2.

Gene and exon expression of Human Umbilical Vein Endothelial Cell under Mimic Hypoxia Stress

(Submitter supplied) Human umbilical vein endothelial cells (HUVECs) were insulted with cobalt chloride to induce cell apoptosis and alternative splicing in the mimic-hypoxia environment. We use Affymetrix exon array to reveal differential expression from transcript-level and exon-level in genome-wide.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL5188 GPL5175
12 Samples
Download data: CEL
Series
Accession:
GSE12546
ID:
200012546
3.

Gene expression of human soft tissue sarcoma

(Submitter supplied) Gene expression profiles of 39 human sarcoma samples (GSM 52571-GSM52609) and 15 control samples (GSM52556-GSM52570) were assessed using Affymetrix HG U133A oligonucleotide arrays. Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1209
Platform:
GPL96
54 Samples
Download data
Series
Accession:
GSE2719
ID:
200002719
4.
Full record GDS1209

Sarcoma and hypoxia

Expression profiling of soft tissue sarcoma samples. Hypoxic regions often develop in tumors as they increase in size. Results provide insight into the expression of hypoxia-related genes in sarcomas.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state, 23 tissue sets
Platform:
GPL96
Series:
GSE2719
54 Samples
Download data
DataSet
Accession:
GDS1209
ID:
1209
5.

Rat brain microvessel SAGE

(Submitter supplied) SAGE analysis of genes expressed in rat brain microvessels. Keywords: Novel gene identification
Organism:
Rattus norvegicus
Type:
Expression profiling by SAGE
Platform:
GPL23
1 Sample
Download data
Series
Accession:
GSE3696
ID:
200003696
6.

CHRF-288-11 and primary human megakaryocytic cell cultures provide novel insights into lineage-specific differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2926
Platform:
GPL887
77 Samples
Download data
Series
Accession:
GSE8914
ID:
200008914
7.

Temporal expression profile of megakaryocytic differentiation primary CD34+ cell culture

(Submitter supplied) Little is known about the global transcriptional program underlying megakaryocytic (Mk) differentiation, maturation, and apoptosis. Using DNA microarrays and Q-RT-PCR, we examined the transcriptional profile of Mk differentiation human CD34-positive hematopoietic stem and progenitor cells cultured with thrombopoietin, interleukin-3, and Flt3-ligand. The goal this study was to identify genes involved in the various facets of Mk differentiation including commitment, polyploidization, proplatelet formation, and apoptosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
36 Samples
Download data
Series
Accession:
GSE3839
ID:
200003839
8.

Temporal expression profile of CHRF-288 cell line after phorbol ester stimulation

(Submitter supplied) Little is known about the global transcriptional program underlying megakaryocytic (Mk) differentiation, maturation, and apoptosis. Using DNA microarrays and Q-RT-PCR, we examined the transcriptional profile of phorbol-ester-induced Mk differentiation of the megakaryoblastic CHRF-288-11 (CHRF) cell line – a model system for investigating megakaryopoiesis. The goals of this study were to (1) verify the megakaryocytic nature of the CHRF cell line at the transcriptional level, and (2) extract novel insights into the key facets of Mk maturation including polyploidization, proplatelet formation, and apoptosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL887
41 Samples
Download data
Series
Accession:
GSE3838
ID:
200003838
9.
Full record GDS2926

Megakaryocytic differentiation: time course

Temporal analysis of phorbol ester-treated CHRF-288-11 megakaryoblastic cells induced to undergo megakaryocytic (Mk) differentiation and primary Mk (PriMk) cells derived from cytokine-treated CD34+ peripheral blood cells. Results provide insight into molecular mechanisms underlying megakaryopoiesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, log e ratio, 4 agent, 2 cell line, 13 time sets
Platform:
GPL887
Series:
GSE8914
77 Samples
Download data
DataSet
Accession:
GDS2926
ID:
2926
10.

Hypoxic shock in DLD-1 cells

(Submitter supplied) Combining our full-length cDNA method and the massively-parallel sequencing technology, we developed a simple method to collect precise positional information of transcriptional start sites (TSSs) together with digital information of the gene expression levels in a high throughput manner. We applied this method to observe gene expression changes in a colon cancer cell line cultured in normoxic and hypoxic conditions. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
1 Sample
Download data: TXT
Series
Accession:
GSE14048
ID:
200014048
11.

Aortic stiffness

(Submitter supplied) BACKGROUND: Previous genomic studies with human tissues have compared differential gene expression between 2 conditions (ie, normal versus diseased) to identify altered gene expression in a binary manner; however, a potentially more informative approach is to correlate the levels of gene expression with quantitative physiological parameters. METHODS AND RESULTS: In this study, we have used this approach to examine genes whose expression correlates with arterial stiffness in human aortic specimens. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8300
10 Samples
Download data
Series
Accession:
GSE420
ID:
200000420
12.

Comparison of expression profile between human Müller cells, HMCL-I and HMCL-II

(Submitter supplied) Müller cells are the principal glial cells in the retina. Alterations in Müller cell behaviour are observed in retinal tissue from patients with proliferative diabetic retinopathy. The purpose of this study was to compare gene and protein expression profile of normal human Müller cells (NHMC) with two spontaneously human Müller cell lines generated from type 1 (HMCL-I) and type 2 (HMCL-II) diabetic donors using Serial Analysis Gene Expression (SAGE). more...
Organism:
Homo sapiens
Type:
Expression profiling by SAGE
Platform:
GPL2750
3 Samples
Download data
Series
Accession:
GSE3118
ID:
200003118
13.

Astrocyte and Hela cell response to hypoxia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1779
Platform:
GPL570
12 Samples
Download data
Series
Accession:
GSE4483
ID:
200004483
14.

HeLa response to hypoxia

(Submitter supplied) Oxygen is vital for the development and survival of mammals. In response to hypoxia, the brain initiates numerous adaptive responses at the organ level as well as at the molecular and cellular level, including the alteration of gene expression. Astrocytes play critical roles in the proper functioning of the brain, thus the manner in which astrocytes respond to hypoxia is likely important in determining the outcome of brain hypoxia. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data
Series
Accession:
GSE3051
ID:
200003051
15.

Astrocytic response to hypoxia

(Submitter supplied) Oxygen is vital for the development and survival of mammals. In response to hypoxia, the brain initiates numerous adaptive responses at the organ level as well as at the molecular and cellular level, including the alteration of gene expression. Astrocytes play critical roles in the proper functioning of the brain, thus the manner in which astrocytes respond to hypoxia is likely important in determining the outcome of brain hypoxia. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data
Series
Accession:
GSE3045
ID:
200003045
16.
Full record GDS1779

Hypoxia effect on astrocytes

Analysis of purified primary astrocytes exposed to hypoxia for 24 hours. Gene expression in HeLa cells also examined. Astrocytes play critical roles in the proper functioning of the brain. Results provide insight into the molecular events underlying the astrocytic responses to hypoxia.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 cell type, 2 stress sets
Platform:
GPL570
Series:
GSE4483
12 Samples
Download data
DataSet
Accession:
GDS1779
ID:
1779
17.

A toxicogenomic profile of Mn in Human Astrocytes

(Submitter supplied) Exposure of adult humans to manganese (Mn) has long been known to cause neurotoxicity. Recent evidence also suggests that exposure of children to Mn is associated with developmental neurotoxicity. Astrocytes are critical for the proper functioning of the nervous system, and they play active roles in neurogenesis, synaptogenesis and synaptic neurotransmission. In this report, to help elucidate the molecular events underlying Mn neurotoxicity, we systematically identified the molecular targets of Mn in primary human astrocytes by using microarray gene expression profiling and computational data analysis algorithms. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data
Series
Accession:
GSE5079
ID:
200005079
18.

Expression data from GFAP-negative LC cells exposed to 24 hours of hypoxia

(Submitter supplied) Vascular hypoperfusion is a pathological phenomenon in the glaucomatous optic nerve head. We report transcriptional responses in GFAP-negative LC cells exposed to in-vitro hypoxic stress (1%O2).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
6 Samples
Download data: CEL
Series
Accession:
GSE26820
ID:
200026820
19.

Serial analysis of gene expression in the corneal endothelium of Fuchs' dystrophy

(Submitter supplied) PURPOSE: To compare the gene expression profiles of normal human corneal endothelium with Fuchs' corneal endothelium, by using serial analysis of gene expression (SAGE). METHODS: Three pairs of normal human corneas were obtained from eye banks. Thirteen bisected Fuchs' corneal buttons were processed at the time of corneal transplantation. The endothelia of normal and Fuchs'-affected corneas were stripped, and total RNA was isolated. more...
Organism:
Homo sapiens
Type:
Expression profiling by SAGE
Platform:
GPL4
2 Samples
Download data
Series
Accession:
GSE505
ID:
200000505
20.

Bovine Glomerular and Aortic Endothelial Cells

(Submitter supplied) SAGE libraries were prepared from mRNA of cultured bovine glomerular and aortic endothelial cells. Cells both cell lines were positive for acetylated LDL uptake and vWF expression, and were proven to be free of non-endothelial cells. Cultures were studied at passage 9-10. The cells were confluent, cultured in parallel, under identical conditions. Cells were plated on gelatin coated cell culture plastic in RPMI 1640 medium containing 10% FBS and streptomycin/penicillin. more...
Organism:
Bos taurus
Type:
Expression profiling by SAGE
Platform:
GPL223
2 Samples
Download data
Series
Accession:
GSE110
ID:
200000110
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