GEO DataSets

(Submitter supplied) Oxygen is vital for the development and survival of mammals. In response to hypoxia, the brain initiates numerous adaptive responses at the organ level as well as at the molecular and cellular level, including the alteration of gene expression. Astrocytes play critical roles in the proper functioning of the brain, thus the manner in which astrocytes respond to hypoxia is likely important in determining the outcome of brain hypoxia. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1779

Platform:

GPL570

12 Samples

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(Submitter supplied) Oxygen is vital for the development and survival of mammals. In response to hypoxia, the brain initiates numerous adaptive responses at the organ level as well as at the molecular and cellular level, including the alteration of gene expression. Astrocytes play critical roles in the proper functioning of the brain, thus the manner in which astrocytes respond to hypoxia is likely important in determining the outcome of brain hypoxia. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

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Analysis of purified primary astrocytes exposed to hypoxia for 24 hours. Gene expression in HeLa cells also examined. Astrocytes play critical roles in the proper functioning of the brain. Results provide insight into the molecular events underlying the astrocytic responses to hypoxia.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell type, 2 stress sets

Platform:

GPL570

Series:

GSE4483

12 Samples

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(Submitter supplied) Exposure of adult humans to manganese (Mn) has long been known to cause neurotoxicity. Recent evidence also suggests that exposure of children to Mn is associated with developmental neurotoxicity. Astrocytes are critical for the proper functioning of the nervous system, and they play active roles in neurogenesis, synaptogenesis and synaptic neurotransmission. In this report, to help elucidate the molecular events underlying Mn neurotoxicity, we systematically identified the molecular targets of Mn in primary human astrocytes by using microarray gene expression profiling and computational data analysis algorithms. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

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(Submitter supplied) Cultures of human aortic (HAEC) and pulmonary artery endothelial cells (HPAEC) were exposured to short-term chronic hypoxia (1% O2) for either 0h, 8h or 24h Keywords: Time course, cell-type comparison

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL4

6 Samples

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(Submitter supplied) Gene expression in human optic nerve head (ONH) astrocytes exposed to either 60 mm Hg hydrostatic pressure (HP) or control ambient pressure (CP) was compared using Affymetrix GeneChip microarrays to identify HP-responsive genes. Primary ONH astrocytes from two male Caucasian donors (passage 4) were grown to 75% confluence and were exposed for 6, 24 or 48 h to control ambient pressure (CP6, CP24, CP48) or hydrostatic pressure (HP6, HP24, HP48), or harvested at the beginning of the pressure experiment (CP0). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS532

Platform:

GPL8300

44 Samples

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Temporal analysis of how astrocytes in the optic nerve head (ONH) respond to changes in intraocular pressure (IOP). ONH astrocytes exposed to 60 mm Hg hydrostatic pressure for 6, 24, and 48 hours. Lends understanding to pathogenesis of glaucoma.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol, 4 time sets

Platform:

GPL8300

Series:

GSE758

44 Samples

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(Submitter supplied) The aim of the experiment was to determine the effect of cyclic stretch-relaxation ("stretch") on gene expression patterns in normal diploid human bladder smooth muscle cells. Cells plated on silicone elastomer bottomed 6-well culture dishes were grown to ~80% confluence, serum-depleted for 48h and subjected to cyclic stretch-relaxation at 20% elongation for 4h. Cells seeded in stretch plates but not subjected to stretch served as controls. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS906

Platform:

GPL96

8 Samples

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Expression profiling of cultured bladder smooth muscle cells subjected to repetitive mechanical stimulation for 4 hours. Chronic overdistension results in bladder wall thickening, associated with loss of muscle contractility. Results identify genes whose expression is altered by mechanical stimuli.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL96

Series:

GSE1595

8 Samples

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(Submitter supplied) Gene expression profiles of 39 human sarcoma samples (GSM 52571-GSM52609) and 15 control samples (GSM52556-GSM52570) were assessed using Affymetrix HG U133A oligonucleotide arrays. Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1209

Platform:

GPL96

54 Samples

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Expression profiling of soft tissue sarcoma samples. Hypoxic regions often develop in tumors as they increase in size. Results provide insight into the expression of hypoxia-related genes in sarcomas.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 23 tissue sets

Platform:

GPL96

Series:

GSE2719

54 Samples

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(Submitter supplied) The central nervous system normally functions at O2 levels which would be regarded as hypoxic by most other tissues. However, most in vitro studies of neurons and astrocytes are conducted under hyperoxic conditions without consideration of O2-dependent cellular adaptation. We analyzed the reactivity of astrocytes to 1, 4 and 9% O2 tensions compared to the cell culture standard of 20% O2, to investigate their ability to sense and translate this O2 information to transcriptional activity. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

12 Samples

Download data: TXT

(Submitter supplied) Identify genes with increased transcript abundance after low oxygen stress in Drosophila adults. Keywords: hypoxic response

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL2991

8 Samples

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(Submitter supplied) High altitude environments are characterized by the unique and unavoidable stress of chronic hypoxia. While much is known about gene expression responses to acute or in vitro hypoxia, less is known about the gene expression profiles of animals exposed to systemic chronic hypoxia, such as that experienced at high elevations. Here we simulated the hypoxic environment of two high altitude elevations,and a third chamber recieved ambient Reno air. more...

Organism:

Mus musculus domesticus; Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4929

Platform:

GPL1261

8 Samples

Download data: CEL

Analysis of livers of C57BL/6 males housed for 32 days in chambers that simulated the hypoxic environment of an altitude of 1400, 3000, or 4500 meters. Results provide insight into the molecular mechanisms underlying acclimatization to high altitude hypoxia.

Organism:

Mus musculus; Mus musculus domesticus

Type:

Expression profiling by array, transformed count, 3 stress sets

Platform:

GPL1261

Series:

GSE15891

8 Samples

Download data: CEL

(Submitter supplied) Gene expression measurements were carried out in human primary astrocytes treated with either 0.1% DMSO (Control) or 300nM Topotecan for 24h and 48h, to assess the effect of topoisomerase I inhibition on the transcription of long genes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

12 Samples

Download data: TXT